Results 71 to 80 of about 50,737 (331)

Microglial adenosine A2A receptor in the paraventricular thalamic nucleus regulates pain sensation and analgesic effects independent of opioid and cannabinoid receptors

Frontiers in Pharmacology
IntroductionThe paraventricular thalamic nucleus (PVT) is recognized for its critical role in pain regulation, yet the precise molecular mechanisms involved remain poorly understood. Here, we demonstrated an essential role of the microglial adenosine A2A
Yiping Cao, Yiping Cao, Yiping Cao, Zhou Wu, Zhou Wu, Zhou Wu, Moruo Zhang, Moruo Zhang, Moruo Zhang, Ran Ji, Ran Ji, Ran Ji, Hongxing Zhang, Hongxing Zhang, Hongxing Zhang, Lingzhen Song, Lingzhen Song, Lingzhen Song   +17 more
doaj   +1 more source

Socioeconomic determinants of psychotropic drug utilisation among elderly: a national population-based cross-sectional study

BMC Public Health, 2010
Background Psychotropic drugs are commonly utilised among the elderly. This study aimed to analyse whether two socioeconomic determinants - income and marital status - are associated with differences in utilisation of psychotropic drugs and potentially ...
Petzold Max, Andersson Karolina, Lesén Eva, Carlsten Anders   +3 more
doaj   +1 more source

Zero-shot Learning of Drug Response Prediction for Preclinical Drug Screening [PDF]

arXiv, 2023
Conventional deep learning methods typically employ supervised learning for drug response prediction (DRP). This entails dependence on labeled response data from drugs for model training. However, practical applications in the preclinical drug screening phase demand that DRP models predict responses for novel compounds, often with unknown drug ...
arxiv  

High‐throughput liquid chromatography‐vacuum differential mobility spectrometry‐mass spectrometry for the analysis of isomeric drugs of abuse in human urine

Drug Testing and Analysis, EarlyView.
This report describes the potential of vacuum differential mobility spectrometry (DMS) as an additional separation dimension to reduce liquid chromatography (LC‐MS) analysis time while maintaining good quantitative performance. A 1‐min trap/elute LC‐vDMS‐SIM/MS method for quantification of 11 drugs of abuse was developed and applied to the analysis of ...
Maria Fernanda Cifuentes Girard, Patrick Knight, Gérard Hopfgartner   +2 more
wiley   +1 more source

Simultaneous monitoring of activity and heart rate variability in depressed patients: A pilot study using a wearable monitor for 3 consecutive days

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 457-467, December 2022., 2022
By using a wearable sensor we examined 3‐dimensional acceleration and heart rate variability (HRV) simultaneously in depressive episode of mood disorders. We found reduced activity and altered HRV indices in depressed patients, compared with healthy participants, particularly in males. Moreover, we found that sympathetic load during sleep significantly
Norie Koga, Yoko Komatsu, Ryo Shinozaki, Ikki Ishida, Yusuke Shimizu, Sonoko Ishimaru, Hiroshi Kunugi   +6 more
wiley   +1 more source

Lysosomes finely control macrophage inflammatory function via regulating the release of lysosomal Fe2+ through TRPML1 channel

Nature Communications
Lysosomes are best known for their roles in inflammatory responses by engaging in autophagy to remove inflammasomes. Here, we describe an unrecognized role for the lysosome, showing that it finely controls macrophage inflammatory function by manipulating
Yanhong Xing, Meng-meng Wang, Feifei Zhang, Tianli Xin, Xinyan Wang, Rong Chen, Zhongheng Sui, Yawei Dong, Dongxue Xu, Xingyu Qian, Qixia Lu, Qingqing Li, Weijie Cai, Meiqin Hu, Yuqing Wang, Jun-li Cao, Derong Cui, Jiansong Qi, Wuyang Wang   +18 more
doaj   +1 more source

Prescribing pattern of psychotropic drugs used in non-psychiatric patients among outpatient department of two teaching hospitals in Bangladesh

Bangladesh Journal of Pharmacology, 2015
The objectives were to evaluate the prevalence, pattern and rational of psychotropic drugs prescribing by general physicians in two teaching hospitals in Bangladesh in non-psychiatric patient.
Nazmun Nahar Alam, Ferdous Ara, Md. Jalal Uddin Iqbal   +2 more
doaj   +1 more source

Clinical connectivity map for drug repurposing: using laboratory tests to bridge drugs and diseases [PDF]

arXiv, 2020
Drug repurposing has attracted increasing attention from both the pharmaceutical industry and the research community. Many existing computational drug repurposing methods rely on preclinical data (e.g., chemical structures, drug targets), resulting in translational problems for clinical trials.
arxiv  

Metabolism study of 3‐chloromethcathinone (3‐CMC) by dried blood spot (DBS) sampling after controlled administration using a murine model

Drug Testing and Analysis, EarlyView.
The metabolism of 3‐chloromethcathinone (3‐CMC) was studied after controlled administration in a murine model using the dried blood spot (DBS) technique for the sampling, storage and purification of blood samples. The metabolite profile of 3‐CMC was studied by LC‐HRMS, while the stability of 3‐CMC and its three identified metabolites was also assessed ...
Serena Mestria, Sara Odoardi, Valeria Valentini, Giorgia Corli, Marta Bassi, Matteo Marti, Sabina Strano‐Rossi   +6 more
wiley   +1 more source

Recent findings on subjective well‐being and physical, psychiatric, and social comorbidities in individuals with schizophrenia: A literature review

Neuropsychopharmacology Reports, Volume 42, Issue 4, Page 430-436, December 2022., 2022
Abstract Aim Care for people with schizophrenia is shifting the locus from long‐stay mental hospitals to nonspecialized community‐based settings. Knowledge on the care is not a sole property of psychiatric specialists. Community healthcare workers who do not specialize in psychiatry are recommended to learn more about schizophrenia.
Yupeng He, Ayako Tanaka, Taro Kishi, Yuanying Li, Masaaki Matsunaga, Shinichi Tanihara, Nakao Iwata, Atsuhiko Ota   +7 more
wiley   +1 more source