Results 61 to 70 of about 2,355,470 (295)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

IMPLEMENTASI FMEA (FAILURE MODE AND EFFECT ANALYSIS) PADA MESIN BUBUT KONVENSIONAL DI PT. RAJA AMPAT INDOTIM

, 2022
Abstrak: Seiring berjalannya waktu, kondisi fasilitas yang digunakan untuk membantu proses produksi pada PT. Raja Ampat Indotim mengalami penurunan kemampuan dan fungsi yang akan mengakibatkan kerugian, salah satu fasilitas yang sering digunakan yakni ...
Santoso, Deri Teguh, Utomo, Alif Imam
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

PENGARUH KOMPETENSI, MOTIVASI KERJA, DAN DISIPLIN KERJA TERHADAP KEPUASAN KERJA KARYAWAN (Studi Pada PT. Sumber Prima Anugrah Abadi [PDF]

EnglishThis study aims to determine the effect of Competence, Work Motivation, and Work Discipline on Job Satisfaction at PT Sumber Prima Anugrah Abadi. The population in this study were 250 employees of PT. Sumber Prima Anugrah Abadi. The sample used in
Oktaviani, Anggie Yasmin
core   +1 more source

Editorial - PT

PORTO ARTE: Revista de Artes Visuais, 2017
Equipe ...
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Castelo Rá-Tim-Bum: o educativo como entretenimento (resenha)

Linhas Críticas, 2000
Duas “lógicas” diferentes presidem o funcionamento da Educação e da TV. Objetivos, procedimentos, estruturas, institucionalização, a própria história – da escola e da televisão – são tão diversos que a expectativa é a do desencontro. Resenha do livro:
José Luiz Braga
doaj   +1 more source

PEMBUATAN SISTEM INFORMASI GARDU INDUK PT. PLN (Persero) APP SEMARANG SE-KOTA SEMARANG DENGAN JAVA ANDROID [PDF]

, 2017
Perusahaan Listrik Negara (PLN) atau PT. PLN (Persero) adalah sebuah BUMN (Badan Usaha Milik Negara) yang bertugas melaksanakan operasi dan pemeliharaan semua aspek kelistrikan yang ada di Indonesia. PT.
Muslim, Much Aziz, Roviaji, Rizky
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source