Results 61 to 70 of about 2,233,699 (194)

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Prediction of Poor Outcomes in Patients with Colorectal Cancer: Elevated Preoperative Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT)

Cancer Management and Research, 2020
Lin Zhang,1,2,* Juan Ye,2– 4,* Qiuyun Luo,2 Miaohuan Kuang,1 Minjie Mao,1 Shuqin Dai,1 Xueping Wang1 1Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation
Zhang L, Ye J, Luo Q, Kuang M, Mao M, Dai S, Wang X   +6 more
doaj  

Castelo Rá-Tim-Bum: o educativo como entretenimento (resenha)

Linhas Críticas, 2000
Duas “lógicas” diferentes presidem o funcionamento da Educação e da TV. Objetivos, procedimentos, estruturas, institucionalização, a própria história – da escola e da televisão – são tão diversos que a expectativa é a do desencontro. Resenha do livro:
José Luiz Braga
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Pt-TiO₂ Bilayered Hemispherical Nanoshells with Tunable Pt Distribution for Chemically Self-Propelled Colloidal Motors

The control of colloidal motors’ motion is crucial for their practical applications. The modulation of the active component distribution on the motors is one of the effective routes to controlling their motion but still in challenge.
Shuyi Zhu (11115068), Weiping Cai (299830), Zhipeng Zhao (4971091), Yujing Guo (2229826), Yi Wei (434518), Hao Fu (755255), Hongwen Zhang (829826), Qian Zhao (217607), Le Zhou (173199)   +8 more
core   +3 more sources

Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer

Molecular Oncology, EarlyView.
New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau, Daniel Pincher, Clifford Young, Nicholas Chappell, Noor A. Lokman, Parul Mittal, Leigh Donnellan, Martin K. Oehler, Doug A. Brooks, Peter Hoffmann   +9 more
wiley   +1 more source

A comparative study of PtCo/C Alloys and Pt/C as cathode catalysts for fuel cell applications

, 2009
Commercialisation of fuel cells for automotive applications requires catalysts with both improved activity, particularly for the cathodic oxygen reduction reaction (ORR), and stability over commercial platinum only catalysts.
Burton, Sarah Louise
core   +1 more source

PT-IC-ddPCR quantify PT modification frequency.

, 2019
(A) Schematic diagram of the PT-IC-ddPCR quantified the DNA PT modification frequency at a specific site. Left (System A): DNA sample was firstly treated with iodine, then unmodified DNA was quantified as X copies by ddPCR using the primers and probe ...
Yihua Sun (109335), Delin You (323967), Jinli Li (5707511), Lingxin Kong (381050), Zixin Deng (31222), Litao Yang (50058), Yi Chen (38576), Tao Zheng (146941), Sucheng Zhu (6533063)   +8 more
core   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Memória: fragmentos de um processo histórico

Plural, 2000
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Adríana Thomazoni Claro Roberto
doaj   +1 more source