Results 31 to 40 of about 30,623 (153)
Expression of Gli3 and PTCH1 mRNA in gastric tumors with PTCH1 mutations.
, 2013 Scatter plots for Gli3 and PTCH1, two hedgehog pathway down-stream genes expressed at relatively higher levels are shown according to their PTCH1 mutation status. Expression values have been RMA normalized and presented as log value.
Han Chang (101808) +6 more
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Rescue of holoprosencephaly in fetal alcohol-exposed Cdon mutant mice by reduced gene dosage of Ptch1. [PDF]
PLoS ONE, 2013 Holoprosencephaly (HPE) is a commonly occurring developmental defect in which midline patterning of the forebrain and midface is disrupted. Sonic hedgehog (SHH) signaling is required during multiple stages of rostroventral midline development, and ...
Mingi Hong, Robert S Krauss
doaj +1 more source
Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells
Molecules, 2021 We previously reported that methiothepin, a small molecule known as a nonselective serotonin 5-HT receptor antagonist, inhibited the doxorubicin efflux activity of the Hedgehog receptor Ptch1 and enhanced the cytotoxic, pro-apoptotic, anti-proliferative,
Nelly Durand +5 more
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Ptch1 Inhibits Smo Intercellularly
, 2013 (A) Detaching and mixing of two populations of fluorescently labelled cells resulted in a homogenous mixture with intimate cell–cell contacts. The procedure is summarized in the left panel. Original magnification is 400×.
Sandra van de Water (5654098) +5 more
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Nevoid Basal Cell Carcinoma Syndrome: Three Cases from the Same Family
Indian Journal of DermatologyNevoid basal cell carcinoma syndrome (NBCCS) is a rare autosomal dominant disease caused by PTCH gene mutation. Despite sporadic cases and case series reported worldwide, few pedigrees have been described.
Ying Yan +5 more
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Ptch1 Secretes Smo-Inhibitory 3β-Hydroxysteroids
, 2013 (A) The left panel shows a schematic representation of the medium transfer experiments, in which medium was incubated on (transfected) donor cells and subsequently transferred to reporter cells.
Sandra van de Water (5654098) +5 more
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PLoS ONE, 2013 BackgroundThe keratocystic odontogenic tumor (KCOT) is a locally aggressive cystic jaw lesion that occurs sporadically or in association with nevoid basal cell carcinoma syndrome (NBCCS).
Yan-Yan Guo +5 more
doaj +1 more source
Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features. [PDF]
PLoS ONE, 2013 Keratocystic odontogenic tumor (KCOT) arises as part of Gorlin syndrome (GS) or as a sporadic lesion. Gene mutations and loss of heterozygosity (LOH) of the hedgehog receptor PTCH1 plays an essential role in the pathogenesis of KCOT.
Yasuyuki Shimada +6 more
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YAP interacts with PTCH1 Through its WW Domains.
, 2015 A) Intact PPxY motifs in PTCH1 are required for binding to YAP. Two PPxY sequences in PTCH1 were mutated to PPxA. Wild type (WT) or single (PY1* or PY2*) or double (PY1*&2*) mutants of PTCH1 in Flag-tag vector were transiently co-transfected with YAP2 ...
Marius Sudol (590085) +5 more
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Hh signaling cannot be regulated by NRF2 in PTCH1−/−;p62-knockdown cells.
, 2020 (A) Immunoblot analysis of PTCH1, NRF2, p62, Ac-Tub, ARL13B, LC3-I and II, OFD1, and BBS4 in WT, PTCH1−/−, and PTCH1−/−;p62-knockdown H1299 cells treated with bixin (40 μM) for 0, 4, 24, or 48 h.
Donna D. Zhang (261086) +4 more
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