Serpine2/PN-1 Is Required for Proliferative Expansion of Pre-Neoplastic Lesions and Malignant Progression to Medulloblastoma. [PDF]
PLoS ONE, 2015 Medulloblastomas are malignant childhood brain tumors that arise due to the aberrant activity of developmental pathways during postnatal cerebellar development and in adult humans.
Catherine Vaillant +11 more
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Investigating Tom1 as a Candidate Regulator of Ptch1 [PDF]
, 2012 Sonic hedgehog (Shh) is a signaling molecule that is involved in patterning the embryo and regulates adult stem cell homeostasis. Patched1 (Ptch1) is the receptor for Shh and upon binding to Shh is endocytosed, allowing downstream signaling to occur ...
Crawford, Michelle Audrey
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Simultaneous Detection of Both Single Nucleotide Variations and Copy Number Alterations by Next-Generation Sequencing in Gorlin Syndrome. [PDF]
PLoS ONE, 2015 Gorlin syndrome (GS) is an autosomal dominant disorder that predisposes affected individuals to developmental defects and tumorigenesis, and caused mainly by heterozygous germline PTCH1 mutations.
Kei-ichi Morita +9 more
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, 2020 (A) H1299 and MEF cells were transfected with pGL4.22 vector containing the promoter of human PTCH1 or the promoter of mouse Ptch1 and further treated with bixin (40 μM) for 16 h, followed by a dual luciferase assay.
Donna D. Zhang (261086) +4 more
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Hedgehog Signaling as a Therapeutic Target for Airway Remodeling and Inflammation in Allergic Asthma
Cells, 2022 Genome-wide association studies (GWAS) have shown that variants of patched homolog 1 (PTCH1) are associated with lung function abnormalities in the general population.
Anthony Tam +13 more
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Expression of Hedgehog Signaling Pathway Proteins in Basal Cell Carcinoma: Clinicopathologic Study
Clinical, Cosmetic and Investigational Dermatology, 2022 Li-Jia Deng, Meng Jia, Si-Yu Luo, Feng-Zeng Li, Sheng Fang Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People’s Republic of ChinaCorrespondence: Sheng Fang, Department of Dermatology, The First ...
Deng LJ, Jia M, Luo SY, Li FZ, Fang S
doaj
A model for PTCH1/Ptch1-associated tumors comprising mutational inactivation and gene silencing
, 2005 Mutations of the Sonic hedgehog (SHH) receptor, Patched I (PITCH I), have been identified in a variety of tumors. PTCH1 is usually considered to be a tumor suppressor gene. However, one normal allele is retained in many tumors.
Tauber, S. +8 more
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Repression of smoothened by patched-dependent (pro-)vitamin D3 secretion.
PLoS Biology, 2006 The developmentally important hedgehog (Hh) pathway is activated by binding of Hh to patched (Ptch1), releasing smoothened (Smo) and the downstream transcription factor glioma associated (Gli) from inhibition.
Maarten F Bijlsma +5 more
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Frontiers in Oncology, 2020 About 30% of medulloblastomas (MBs), a tumor of the cerebellum, arise from cerebellar granule cell precursors (GCPs) undergoing transformation following activation of the Sonic hedgehog (Shh) pathway. To study this process, we generated a new MB model by
Manuela Ceccarelli +3 more
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PTCH1 (patched homolog 1 (Drosophila)) [PDF]
, 1999 Review on PTCH1 (patched homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL
core +1 more source