Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency
Cells, 2018 One of the crucial challenges in the clinical management of cancer is resistance to chemotherapeutics. Multidrug resistance (MDR) has been intensively studied, and one of the most prominent mechanisms underlying MDR is overexpression of adenosine ...
Isabelle Mus-Veteau, Anida Hasanovic
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Discover Oncology, 2022 Nevoid basal cell carcinoma syndrome (NBCCS) is an autosomal dominant disorder with an increased incidence of tumors, such as basal cell carcinomas and medulloblastomas.
Akihiro Umezawa +2 more
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PTCH1 is a reliable marker for predicting imatinib response in chronic myeloid leukemia patients in chronic phase. [PDF]
PLoS ONE, 2017 Patched homolog 1 gene (PTCH1) expression and the ratio of PTCH1 to Smoothened (SMO) expression have been proposed as prognostic markers of the response of chronic myeloid leukemia (CML) patients to imatinib. We compared these measurements in a realistic
Juan M Alonso-Dominguez +17 more
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Multiple Basal Cell Carcinomas in an Adolescent with an MLPA-Detected PTCH1-Region Deletion and a Gorlin-Goltz Phenotype [PDF]
Balkan Journal of Medical GeneticsGorlin-Goltz syndrome, also known as nevoid basal cell carcinoma syndrome or basal cell naevus syndrome, is a rare hereditary cancer-predisposition disorder most often caused by disruption of the Hedgehog signaling pathway, particularly alterations of ...
Mitrova Telenta J +9 more
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Inhibition of PTCH1 drug efflux activity enhances chemotherapy efficacy against triple negative breast cancers [PDF]
Translational OncologyOur previous work has revealed that PTCH1, a Hedgehog receptor which is expressed in many aggressive cancers, plays a role in transporting chemotherapeutic drugs out of cancer cells and contributes to their resistance to chemotherapy.
Sarah Cogoluegnes +9 more
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Hsa-mir-1293/GLI1/PTCH1 axis is involved in proliferation, migration, and EMT of laryngeal cancer [PDF]
Brazilian Journal of OtorhinolaryngologyObjective: This study aimed to investigate the specific role and molecular mechanisms of the transcription factor GLI1 and its upstream regulatory miRNA, hsa-mir-1293, in laryngeal cancer development, with a focus on elucidating the function of the hsa ...
Yibo Zhou +8 more
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Regulation of Ptch1 by miR-342-5p and FoxO3 Induced Autophagy Involved in Renal Fibrosis
Frontiers in Bioengineering and Biotechnology, 2020 The pathogenesis of renal fibrosis (RF) is not well understood. Here, we performed an integrative database analysis of miRNAs and mRNAs to discover the major regulatory pathway in RF.
Simin Tang, Wenjun Li
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Challenging interpretation of low-level PTCH1 mosaicism in patients with clinically diagnosed Gorlin syndrome: a case series and review of the literature [PDF]
Hereditary Cancer in Clinical PracticeBackground Individuals meeting clinical diagnostic criteria for Gorlin syndrome typically harbor germline pathogenic variants in PTCH1 or SUFU. The molecular basis of a proportion of cases remains unresolved, with mosaicism a possible explanation for ...
Tanya M. Dwarte +16 more
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Sonic Hedgehog Signalling Pathway and Ameloblastoma – A Review [PDF]
Journal of Clinical and Diagnostic Research, 2015 Ameloblastoma is a benign but aggressive odontogenic neoplasm arising from odontogenic epithelium. Many theories have been proposed to explain the pathogenesis of ameloblatoma.
Pallavi Mishra +4 more
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Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes
eLife, 2021 A long-standing mystery in vertebrate Hedgehog signaling is how Patched 1 (PTCH1), the receptor for Hedgehog ligands, inhibits the activity of Smoothened, the protein that transmits the signal across the membrane. We previously proposed (Kinnebrew et al.,
Maia Kinnebrew +10 more
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