Results 41 to 50 of about 30,623 (153)

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

eLife, 2014
Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue patterns during development.
Shen Yue, Liu-Ya Tang, Ying Tang, Yi Tang, Qiu-Hong Shen, Jie Ding, Yan Chen, Zengdi Zhang, Ting-Ting Yu, Ying E Zhang, Steven Y Cheng   +10 more
doaj   +1 more source

The relationship of Gata3 and Foxa2 targets with Shh⁺Ptch1⁻-/Shh⁻Ptch1⁺-pattern genes.

, 2014
(A) The overlaps between Foxa2 targets in ChIP-seq with ABA ISH annotations and Shh+Ptch1−-/Shh−Ptch1+-pattern genes. (B) The overlaps between 84 Gata3 targets in ChIP-seq with ABA ISH annotations and Shh+Ptch1−-/Shh−Ptch1+-pattern genes.
Jinhua Liu (189844), Gang Wei (372644), Haifang Wang (67779), Jun Yan (28467), Juan Li (146180), Xuelong Wang (104761)   +5 more
core   +1 more source

Alterations in Morphology and Adult Neurogenesis in the Dentate Gyrus of Patched1 Heterozygous Mice

Frontiers in Molecular Neuroscience, 2018
Many genes controlling neuronal development also regulate adult neurogenesis. We investigated in vivo the effect of Sonic hedgehog (Shh) signaling activation on patterning and neurogenesis of the hippocampus and behavior of Patched1 (Ptch1) heterozygous ...
Francesca Antonelli, Arianna Casciati, Mirella Tanori, Barbara Tanno, Maria V. Linares-Vidal, Maria V. Linares-Vidal, Noemi Serra, Noemi Serra, Monserrat Bellés, Monserrat Bellés, Alessandro Pannicelli, Anna Saran, Simonetta Pazzaglia   +12 more
doaj   +1 more source

PTCH1 (patched homolog 1 (Drosophila))

, 1997
Review on PTCH1 (patched homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Huret, JL, JL Huret
core   +1 more source

Ptch2/Gas1 and Ptch1/Boc differentially regulate Hedgehog signalling in murine primordial germ cell migration. [PDF]

, 2020
Gas1 and Boc/Cdon act as co-receptors in the vertebrate Hedgehog signalling pathway, but the nature of their interaction with the primary Ptch1/2 receptors remains unclear.
Cobourne, MT, Kim, Y, Lee, J, Seppala, M, Kim, Yeonjoo, Seppala, Maisa, Lee, Jiyoung, Kim, S-H, Kim, Soo Hyun, Cobourne, Martyn T.; id_orcid   +9 more
core   +1 more source

Unexpected phenotype in a frameshift mutation of PTCH1

Molecular Genetics & Genomic Medicine, 2020
Background Gorlin syndrome, also known as basal cell nevus syndrome (BCNS), is a rare autosomal dominant genetic condition, characterized by the presence of multiple basal cell carcinomas at a young age, odontogenic keratocysts, skeletal anomalies ...
Benedetta Beltrami, Elisabetta Prada, Gianluca Tolva, Giulietta Scuvera, Rosamaria Silipigni, Daniela Graziani, Gaetano Bulfamante, Cristina Gervasini, Paola Marchisio, Donatella Milani   +9 more
doaj   +1 more source

Common genetic variations in Patched1 (PTCH1) gene and risk of hirschsprung disease in the Han Chinese population. [PDF]

PLoS ONE, 2013
Hirschsprung disease (HSCR) is the most frequent genetic cause of congenital intestinal obstruction with an incidence of 1:5000 live births. In a pathway-based epistasis analysis of data generated by genome-wide association study on HSCR, specific ...
Yang Wang, Jun Wang, Weihua Pan, Ying Zhou, Yongtao Xiao, Kejun Zhou, Jie Wen, Tingxi Yu, Wei Cai   +8 more
doaj   +1 more source

PTCH1 (patched homolog 1 (Drosophila))

, 2001
Review on PTCH1 (patched homolog 1 (Drosophila)), with data on DNA, on the protein encoded, and where the gene is ...
Lindstr
core   +1 more source

Molecular alterations in basal cell carcinoma subtypes

Scientific Reports, 2021
A number of genes have been implicated in the pathogenesis of BCC in addition to the Hedgehog pathway, which is known to drive the initiation of this tumour. We performed in-depth analysis of 13 BCC-related genes (CSMD1, CSMD2, DPH3 promoter, PTCH1, SMO,
Lucia Di Nardo, Cristina Pellegrini, Alessandro Di Stefani, Francesco Ricci, Barbara Fossati, Laura Del Regno, Carmine Carbone, Geny Piro, Vincenzo Corbo, Pietro Delfino, Simona De Summa, Maria Giovanna Maturo, Tea Rocco, Giampaolo Tortora, Maria Concetta Fargnoli, Ketty Peris   +15 more
doaj   +1 more source

Activation of hedgehog signaling in mesenchymal stem cells induces cartilage and bone tumor formation via Wnt/β-Catenin

eLife, 2019
Indian Hedgehog (IHH) signaling, a key regulator of skeletal development, is highly activated in cartilage and bone tumors. Yet deletion of Ptch1, encoding an inhibitor of IHH receptor Smoothened (SMO), in chondrocyte or osteoblasts does not cause ...
Qi Deng, Ping Li, Manju Che, Jiajia Liu, Soma Biswas, Gang Ma, Lin He, Zhanying Wei, Zhenlin Zhang, Yingzi Yang, Huijuan Liu, Baojie Li   +11 more
doaj   +1 more source