Results 1 to 10 of about 223,558 (156)

Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy [PDF]

, 2014
Phosphatase and tensin homolog (PTEN) loss is associated with genomic instability. APE1 is a key player in DNA base excision repair (BER) and an emerging drug target in cancer.
Allinson, Ashworth, Ashworth, Bertram, Bosenberg, Botti, Bristow, Burma, Campisi, Curtin, Eng, Eng, Foiani, Gerson, He, Helleday, Hickson, Kelley, Larue, Li, Madhusudan, Madhusudan, Madhusudan, Madhusudan, Maloney, Maloney, Meyskens, Newton-Bishop, Pandolfi, Pandolfi, Parsons, Polyak, Pu, Reis-Filho, Reis-Filho, Ribas, Rimm, Robertson, Rocha, Simeonov, Simeonov, Smalley, Stambolic, Stambolic, Teo, Wadhwa, Wilson, Wilson, Yin, Zhang   +49 more
core   +10 more sources

Novel compounds that synergize with aminoglycoside G418 or eRF3 degraders for translational readthrough of nonsense mutant TP53 and PTEN

RNA Biology, 2023
The TP53 and PTEN tumour suppressor genes are inactivated by nonsense mutations in a significant fraction of human tumours. TP53 nonsense mutant tumours account for approximately one million new cancer cases per year worldwide.
Angelos Heldin, Matko Cancer, Mireia Palomar-Siles, Susanne Öhlin, Meiqiongzi Zhang, Alexander Sun-Zhang, Anna Mariani, Jianping Liu, Vladimir J.N. Bykov, Klas G. Wiman   +9 more
doaj   +1 more source

MicroRNA-21 and microRNA-148a affects PTEN, NO and ROS in canine leishmaniasis

Frontiers in Genetics, 2023
Canine Visceral leishmaniasis (CanL) poses a severe public health threat in several countries. Disease progression depends on the degree of immune response suppression.
Jéssica Henrique De Freitas, Jaqueline Poleto Bragato, Gabriela Torres Rebech, Sidnei Ferro Costa, Marilene Oliveira Dos Santos, Matheus Fujimura Soares, Flávia de Rezende Eugênio, Paulo Sérgio Patto Dos Santos, Valéria Marçal Felix De Lima   +8 more
doaj   +1 more source

MicroRNA-144 silencing attenuates intimal hyperplasia by directly targeting PTEN

Clinical and Experimental Hypertension, 2022
Background Intimal hyperplasia contributed by phenotypic switching of vascular smooth muscle cell (VSMC) plays an important role in the pathogenesis of various cardiovascular diseases.
Xinlong Lian, Ming Lv, Bo Shi
doaj   +1 more source

Interference between miR-21/PTEN/E-Cadherin and Epithelial-Mesenchymal Transition in Various Stages of Chronic HCV Infection [PDF]

Journal of Bioscience and Applied Research, 2022
Hepatocellular carcinoma (HCC) is a major complication associated with hepatitis C viral infection (HCV). The epithelial-mesenchymal transition (EMT) is critical in HCC invasion and metastasis.
Yasser Ali, Mohamed Thabet, Abeer El-Maghraby, Asmaa Gomaa, Omaima Khamiss, Roba Talaat   +5 more
doaj   +1 more source

Personalized Treatment Approach to Metastatic Castration-Resistant Prostate Cancer with BRCA2 and PTEN Mutations: A Case Report

Case Reports in Oncology, 2020
DNA repair mutations (BRCA1 and BRCA2) are found in metastatic castration-resistant prostate cancer (CRPC) patients. Here, we report a case of a 71-year-old male patient with metastatic CRPC along with BRCA2 and PTEN mutations.
Pramod Kumar Julka, Amit Verma, Kush Gupta   +2 more
doaj   +1 more source

Relationship between phosphatase and tensin homolog (PTEN) expression in high grade glioma and histopathologic findings [PDF]

Romanian Journal of Neurology, 2021
Introduction. Malignant glioma is resistant brain tumor to treatment and considered by aggressiveness that fails successful resection. Molecular pathways including PTEN related with tumor behavior. Materials and methods.
Nasim Hayati, Hedieh Moradi Tabriz, Elham Nazar, Reza Gorji   +3 more
doaj   +1 more source

Foxo3a-Mediated DNMT3B Impedes Cervical Cancer Cell Proliferation and Migration Capacities through Suppressing PTEN Promoter Methylation

Journal of Investigative Surgery, 2023
Objective Cervical cancer is linked with the constitutive activation of growth factors and gene mutations-induced pro-survival signaling pathways.
Hongying Li, Yuqin Yuan, Hong Dong, Tinghui Wang, Dunlan Zhang, Limin Zhou, Lu Chen, Xueyan He   +7 more
doaj   +1 more source

CircRAB3B suppresses proliferation, motility, cell cycle progression and promotes the apoptosis of IL-22-induced keratinocytes depending on the regulation of miR-1228-3p/PTEN axis in psoriasis

Autoimmunity, 2021
Introduction Psoriasis is an immune-related chronic skin disease, and interleukin-22 (IL-22) is involved in psoriasis pathogenesis through promoting proliferation and migration abilities of keratinocytes.
Jiajing Lu, Xin Xu, Ying Li, Ning Yu, Yangfeng Ding, Yuling Shi   +5 more
doaj   +1 more source

The prognostic effect of PTEN expression status in colorectal cancer development and evaluation of factors affecting it: MiR-21 and promoter methylation [PDF]

, 2016
Background: PTEN is a tumor suppressor gene which is involved in cellular proliferation, differentiation, and apoptosis. Loss or down-regulation of PTEN plays an important role in human cancers development.
Azadeh, H., Farazmandfar, T., Yazdani, Y., Zekavatian, Z.   +3 more
core   +1 more source