Results 161 to 170 of about 223,608 (200)
Some of the next articles are maybe not open access.
Biochemical Society Transactions, 2007
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. In dephosphorylating the 3-position of the inositol ring of phosphoinositides such as PtdIns(3,4,5)P3, PTEN's lipid phosphatase activity is an important counteracting mechanism in PI3K (phosphoinositide 3-kinase) signalling. This is essential for cell
openaire +2 more sources
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is well known as a tumour suppressor. In dephosphorylating the 3-position of the inositol ring of phosphoinositides such as PtdIns(3,4,5)P3, PTEN's lipid phosphatase activity is an important counteracting mechanism in PI3K (phosphoinositide 3-kinase) signalling. This is essential for cell
openaire +2 more sources
Leukemia Research, 2005
0 d hysiological PTEN substrate is the lipidic second messener phosphatidylinositol-3,4,5-trisphosphate (PIP3). Thus, TEN reverts the phosphoinositide-3-kinases (PI3K) phoshorilation of phosphatidylinositol-4,5-bisphosphate (PIP2) o PIP3. As PIP3 activates the serine–threonine kinase Akt, hich is involved in anti-apoptosis, proliferation and oncoenesis,
Santos, Nuno C. +2 more
openaire +3 more sources
0 d hysiological PTEN substrate is the lipidic second messener phosphatidylinositol-3,4,5-trisphosphate (PIP3). Thus, TEN reverts the phosphoinositide-3-kinases (PI3K) phoshorilation of phosphatidylinositol-4,5-bisphosphate (PIP2) o PIP3. As PIP3 activates the serine–threonine kinase Akt, hich is involved in anti-apoptosis, proliferation and oncoenesis,
Santos, Nuno C. +2 more
openaire +3 more sources
2003
Genetic evidence strongly suggested that a tumor suppressor was located on chromosome 10. During the development of glioblastoma, one copy of chromosome 10 was typically lost (1). Cytogenetic and molecular analysis revealed partial or complete loss of chromosome 10 in bladder, endometrial, and prostate cancer (2,3).
Ramon, Parsons, Laura, Simpson
openaire +2 more sources
Genetic evidence strongly suggested that a tumor suppressor was located on chromosome 10. During the development of glioblastoma, one copy of chromosome 10 was typically lost (1). Cytogenetic and molecular analysis revealed partial or complete loss of chromosome 10 in bladder, endometrial, and prostate cancer (2,3).
Ramon, Parsons, Laura, Simpson
openaire +2 more sources
2010
The PTEN phosphatase has an active site motif characteristic for the protein tyrosine phosphatase superfamily, yet its major substrate is the membrane lipid phosphatidylinositol (3,4,5) trisphosphate (PIP3). PTEN is thus the major antagonist of PI3 kinase signaling, which explains its supreme role in tumor suppression, development, and growth control ...
openaire +2 more sources
The PTEN phosphatase has an active site motif characteristic for the protein tyrosine phosphatase superfamily, yet its major substrate is the membrane lipid phosphatidylinositol (3,4,5) trisphosphate (PIP3). PTEN is thus the major antagonist of PI3 kinase signaling, which explains its supreme role in tumor suppression, development, and growth control ...
openaire +2 more sources
Blood, 2012
Regulation of the Pten tumor suppressor is complex and mediated by varied mechanisms. In this issue of Blood , Wey and colleagues show in a biallelic conditional knockout mouse model of GRP78 and PTEN that heterozygous loss of Grp78 suppresses leukemogenesis mediated by Pten .[1][1] These ...
openaire +2 more sources
Regulation of the Pten tumor suppressor is complex and mediated by varied mechanisms. In this issue of Blood , Wey and colleagues show in a biallelic conditional knockout mouse model of GRP78 and PTEN that heterozygous loss of Grp78 suppresses leukemogenesis mediated by Pten .[1][1] These ...
openaire +2 more sources
Germline PTEN Mutation Analysis for PTEN Hamartoma Tumor Syndrome
2015Clinically, deregulation of PTEN function resulting in reduced PTEN expression and/or activity is implicated in human disease. Cowden syndrome (CS) is an autosomal dominant disorder characterized by benign and malignant tumors. CS-related individual features occur commonly in the general population. Approximately 25 % of patients diagnosed with CS have
Joanne, Ngeow, Charis, Eng
openaire +2 more sources
Methods, 2015
PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since then, various laboratories have reported that PTEN is indeed secreted and available for uptake by other cells in at least two different guises.
Putz, Ulrich +5 more
openaire +3 more sources
PTEN was discovered as a membrane-associated tumor suppressor protein nearly two decades ago, but the concept that it can be secreted and taken up by recipient cells is revolutionary. Since then, various laboratories have reported that PTEN is indeed secreted and available for uptake by other cells in at least two different guises.
Putz, Ulrich +5 more
openaire +3 more sources
Science Signaling, 2013
The phosphatase PTEN works as a lipid phosphatase in the cytoplasm and a protein phosphatase in the nucleus.
openaire +2 more sources
The phosphatase PTEN works as a lipid phosphatase in the cytoplasm and a protein phosphatase in the nucleus.
openaire +2 more sources
2015
PTEN hamartoma tumor syndrome (PHTS) is the molecular diagnostic term describing patients with Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, and other clinical presentations with germline mutation of the PTEN tumor suppressor gene. PHTS confers increased risks for specific malignancies, most notably breast, thyroid, renal, and endometrial cancers.
Jessica, Mester, Eng, Charis
openaire +2 more sources
PTEN hamartoma tumor syndrome (PHTS) is the molecular diagnostic term describing patients with Cowden syndrome, Bannayan-Riley-Ruvalcaba syndrome, and other clinical presentations with germline mutation of the PTEN tumor suppressor gene. PHTS confers increased risks for specific malignancies, most notably breast, thyroid, renal, and endometrial cancers.
Jessica, Mester, Eng, Charis
openaire +2 more sources