Archives of Pathology & Laboratory Medicine, 2022 Context.— Intestinal neuronal dysplasia type B (IND B) is a complex entity involving the enteric nervous system, clinically manifested with constipation in infancy. Diagnosis has been established by histopathologic analysis of rectal biopsies. However, the criteria for the diagnosis have been questioned and modified,
Simone Antunes, Terra +2 more
openaire +2 more sources
Annual Review of Biochemistry, 2014 The importance of PTEN in cellular function is underscored by the frequency of its deregulation in cancer. PTEN tumor-suppressor activity depends largely on its lipid phosphatase activity, which opposes PI3K/AKT activation. As such, PTEN regulates many cellular processes, including proliferation, survival, energy metabolism, cellular architecture, and ...
Carolyn A, Worby, Jack E, Dixon
openaire +4 more sources
Oncogenic microRNA-4534 regulates PTEN pathway in prostate cancer. [PDF]
, 2016 Prostate carcinogenesis involves alterations in several signaling pathways, the most prominent being the PI3K/AKT pathway. This pathway is constitutively active and drives prostate cancer (PCa) progression to advanced metastatic disease. PTEN, a critical
Chowdhary, Harshika +19 more
core +8 more sources
PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex [PDF]
, 2017 PTEN controls three-dimensional (3D) glandular morphogenesis by coupling juxtamembrane signalling to mitotic spindle machinery. While molecular mechanisms remain unclear, PTEN interacts through its C2 membrane-binding domain with the scaffold protein β ...
Anderson +82 more
core +3 more sources
PTEN and p53 Combined Gene Therapy Promote Apoptosis and Chemosensitivity to Oxaliplatin in Colorectal Cancer: An In Vitro Study [PDF]
Advanced Pharmaceutical BulletinPurpose: Cancer is a complex condition and gene therapy has evolved as a promising method for cancer treatment. Studies have demonstrated that PTEN and p53 proteins have remarkable antitumor effects but combined up-regulation of both PTEN and p53 genes ...
Narjes Nakhaee +3 more
doaj +1 more source
Regulatory role of PTEN and microRNA-141 in papillary thyroid cancer
Biotechnology & Biotechnological Equipment, 2020 The aim of this study was to investigate the expression of microRNA (miR)-141 in lymphatic fluid, lymph node and tumor tissues of patients with papillary thyroid cancers (PTC), and its regulating mechanism on tumor infiltration and invasion.
Xianfeng Zhong, Chao Zhang
doaj +1 more source
Targeted next-generation sequencing of dedifferentiated chondrosarcoma in the skull base reveals combined TP53 and PTEN mutations with increased proliferation index, an implication for pathogenesis [PDF]
, 2016 Dedifferentiated chondrosarcoma (DDCS) is a rare disease with a dismal prognosis. DDCS consists of two morphologically distinct components: the cartilaginous and noncartilaginous components.
Cao, Dengfeng +13 more
core +2 more sources
Prognostic value of angiogenic markers of endometrial cancer (literature review)
Сибирский онкологический журнал, 2022 Endometrial cancer is the most common cancer of the female reproductive organs. The purpose of the study was to summarize the available data on the role of angiogenic markers in the development, progression and prognosis of endometrial cancer.
N. S. Zolotukhina, L. F. Gulyaeva
doaj +1 more source
Prognostic Significance of PD-L1 and PTEN Expression in Prostatic Cancer [PDF]
Middle East Journal of Cancer, 2022 Background: Programmed death- ligand 1(PD-L1) acts as an immune checkpoint inhibitor. Phosphatase and tensin homolog (PTEN) is a somatically mutated tumor suppressor gene in numerous types of human cancer. The current study aimed to assess the prognostic
Noha Elaidy +3 more
doaj +1 more source
AKT activation controls cell survival in response to HDAC6 inhibition. [PDF]
, 2016 HDAC6 is emerging as an important therapeutic target for cancer. We investigated mechanisms responsible for survival of tumor cells treated with a HDAC6 inhibitor.
Aboagye, EO +3 more
core +1 more source