Results 41 to 50 of about 223,608 (200)
Journal of Mazandaran University of Medical Sciences, 2021 Background and purpose: T-cell acute lymphoblastic leukemia (T-ALL) is a type of blood malignancy caused by changes in the precursors of T lymphocyte cells. The PTEN gene is one of the most common tumor suppressor genes that mutates in most human cancers,
Malihe Bagheri +2 more
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miR-23b-3p regulates differentiation of osteoclasts by targeting PTEN via the PI3k/AKT pathway
Archives of Medical Science, 2019 Introduction Osteoblasts and osteoclasts are cells of osteoblastic origin, and are vital in homeostasis of the skeleton. miRs are important for functioning, survival and differentiation of osteoclasts.
Jiwei Chai, Liang Xu, Niansheng Liu
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Evaluation of the Expression Level of miR-32 and PTEN in Melanoma [PDF]
Journal of Mazandaran University of Medical Sciences, 2023 Background and purpose: The aim is to investigate the change in the expression level of miR-32 and PTEN genes in tumor samples with melanoma. Materials and methods: This study collected tumor samples from 50 patients and 50 samples from healthy marginal
Zohreh Abdolrahimi +3 more
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Ubiquitylation in immune disorders and cancer: from molecular mechanisms to therapeutic implications [PDF]
, 2012 Conjugation of ubiquitin to proteins (ubiquitylation) has emerged to be one of the most crucial post-translational modifications controlling virtually all cellular processes.
Fulda, Simone +2 more
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MTOR cross-talk in cancer and potential for combination therapy [PDF]
, 2018 The mammalian Target of Rapamycin (mTOR) pathway plays an essential role in sensing and integrating a variety of exogenous cues to regulate cellular growth and metabolism, in both physiological and pathological conditions.
Bazzichetto, C. +7 more
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Drug Design, Development and Therapy, 2023 Juanyong Zhao, Haiyang Liu, Ming Xia, Qian Chen, Lili Wan, Bin Leng, Chengyuan Tang, Guochun Chen, Yu Liu, Lei Zhang, Hong Liu Hunan Key Laboratory of Kidney Disease and Blood Purification, Department of Nephrology, The Second Xiangya Hospital, Central ...
Zhao J +10 more
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Lactobacillus plantarum induces apoptosis in gastric cancer cells via modulation of signaling pathways in Helicobacter pylori [PDF]
BioImpacts, 2020 Introduction: Gastric cancer is considered the second prevalent cause of death around the world. This type of cancer is generally induced by Helicobacter pylori which could colonize within the gastric mucosa of the infected cases.
Hadi Maleki-Kakelar +6 more
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Cowden syndrome - Diagnostic skin signs [PDF]
, 2001 Cowden syndrome is a rare autosomal dominant familial cancer syndrome with a high risk of breast cancer. The most important clinical features include carcinomas of the breast and thyroid, and hamartomatous polyps of the gastrointestinal tract.
Burgdorf, Walter H. C. +2 more
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CDC25 as a common therapeutic target for triple-negative breast cancer - the challenges ahead
Molecular & Cellular Oncology, 2018 The dual phosphatase CDC25 has recently been identified as a target for diverse triple-negative breast cancers including RB1/PTEN/P53-deficient tumors. Moreover, CDC25 inhibitors effectively synergize with PI3K inhibitors to suppress tumor growth.
Eldad Zacksenhaus +11 more
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New models of large-cell neuroendocrine carcinoma and small-cell lung carcinoma
Molecular & Cellular Oncology, 2020 High-grade neuroendocrine lung carcinomas (LCNEC, SCLC) are recalcitrant cancers for which no optimal management has been achieved. We have recently described two models of LCNEC and SCLC developed upon inactivation of 4 tumor suppressors genes (Rb1 (RB ...
Mirentxu Santos
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