Results 91 to 100 of about 13,736 (293)
A robust methodology was developed to generate heritable mutations in a thysanopteran crop pest and virus vector (Frankliniella occidentalis, Fo) using the CRISPR/Cas9 system Two eye colour genes (Fo‐white and Fo‐cinnabar) were identified in the F. occidentalis genome to serve as targets of gene knockout with visible changes in eye pigmentation CRISPR ...
Jinlong Han+5 more
wiley +1 more source
Four new acylated pteridine alkaloids, duramidines A-D, two new acylated thymidine alkaloids, leptoclinidines A and B, two new 1-acylglyceryl-3-(O-carboxyhydroxymethylcholine) alkaloids, durabetaines A and B, three new 1,3-dimethyl-5 ...
Kathryn E. Rudolph+3 more
semanticscholar +1 more source
How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group? [PDF]
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H.
A Hoikkala+70 more
core +2 more sources
Synthesis of 4‐(Phenylamino)quinazoline‐2(1H)‐thiones Using Green Solvents
Environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest with the quinazoline‐2(1H)‐thione core structure, using bio‐based recyclable solvents. Abstract Given the importance of quinazolines and quinazolinethiones in therapeutic and Food and Drug Administration (FDA)‐approved molecules, we thought interesting to ...
Gatien Messire+2 more
wiley +1 more source
A single gene (yes) controls pigmentation of eyes and scales in Heliothis virescens
A yellow-eyed mutant was discovered in a strain of Heliothis virescens, the tobacco budworm, that already exhibited a mutation for yellow scale, y. We investigated the inheritance of these visible mutations as candidate markers for transgenesis.
Thomas M. Brown+4 more
doaj
Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin [PDF]
In the vasculature, a physiologic production of nitric oxide (NO) is maintained by endothelial nitric oxide synthase (eNOS). Induction of inducible nitric oxide synthase (ÍNOS) under inflammatory conditions (e.g. septic shock) resulting in high levels of
Linscheid, Philippe+4 more
core
Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii [PDF]
Background: The proteins of halophilic archaea require high salt concentrations both for stability and for activity, whereas they denature at low ionic strength. The structural basis for this phenomenon is not yet well understood.
Pieper, Ursula+3 more
core +5 more sources
Graphical Abstract and Lay Summary Colorectal cancer treatment (CRC) is challenged by multi‐drug resistance, where cancer cells become resistant to multiple drugs due to efflux pumps or enzymatic detoxification. This study proposes a multi‐pronged approach utilizing PAMAM dendrimers for targeted co‐delivery of genes and drugs to combat CRC.
Bünyamin Bulkurcuoğlu+7 more
wiley +1 more source
An assay was set up for glyceryl ether monooxygenase activity in tissue samples using the novel substrate 1-O-pyrenedecyl-sn-glycerol and high-performance liquid chromatographic analysis of reaction mixtures with fluorescence detection, allowing robust ...
Ernst R. Werner+4 more
doaj
Abstract Common wall lizards (Podarcis muralis) in Italy show a striking variation in body coloration across the landscape, with highly exaggerated black and green colors in hot and dry climates and brown and white colors in cool and wet climates. Males are more intensely colored than females, and previous work has suggested that the maintenance of ...
Maravillas Ruiz Miñano+5 more
wiley +1 more source