Results 91 to 100 of about 13,736 (293)

CRISPR/Cas9‐mediated genome editing of Frankliniella occidentalis, the western flower thrips, via embryonic microinjection

open access: yesInsect Molecular Biology, Volume 33, Issue 6, Page 589-600, December 2024.
A robust methodology was developed to generate heritable mutations in a thysanopteran crop pest and virus vector (Frankliniella occidentalis, Fo) using the CRISPR/Cas9 system Two eye colour genes (Fo‐white and Fo‐cinnabar) were identified in the F. occidentalis genome to serve as targets of gene knockout with visible changes in eye pigmentation CRISPR ...
Jinlong Han   +5 more
wiley   +1 more source

Pteridine-, thymidine-, choline- and imidazole-derived alkaloids from the Australian ascidian, Leptoclinides durus.

open access: yesOrganic and biomolecular chemistry, 2013
Four new acylated pteridine alkaloids, duramidines A-D, two new acylated thymidine alkaloids, leptoclinidines A and B, two new 1-acylglyceryl-3-(O-carboxyhydroxymethylcholine) alkaloids, durabetaines A and B, three new 1,3-dimethyl-5 ...
Kathryn E. Rudolph   +3 more
semanticscholar   +1 more source

How consistent are the transcriptome changes associated with cold acclimation in two species of the Drosophila virilis group? [PDF]

open access: yes, 2015
This work was financially support by a Marie Curie Initial Training Network grant, “Understanding the evolutionary origin of biological diversity” (ITN-2008–213780 SPECIATION), grants from the Academy of Finland to A.H.
A Hoikkala   +70 more
core   +2 more sources

Synthesis of 4‐(Phenylamino)quinazoline‐2(1H)‐thiones Using Green Solvents

open access: yesChemistry – A European Journal, Volume 30, Issue 63, November 12, 2024.
Environmentally friendly process for synthesizing heterocyclic molecules of therapeutic interest with the quinazoline‐2(1H)‐thione core structure, using bio‐based recyclable solvents. Abstract Given the importance of quinazolines and quinazolinethiones in therapeutic and Food and Drug Administration (FDA)‐approved molecules, we thought interesting to ...
Gatien Messire   +2 more
wiley   +1 more source

A single gene (yes) controls pigmentation of eyes and scales in Heliothis virescens

open access: yesJournal of Insect Science, 2001
A yellow-eyed mutant was discovered in a strain of Heliothis virescens, the tobacco budworm, that already exhibited a mutation for yellow scale, y. We investigated the inheritance of these visible mutations as candidate markers for transgenesis.
Thomas M. Brown   +4 more
doaj  

Differential Inhibition of Constitutive and Inducible Nitric Oxide Synthase in Vascular Endothelial Cells by Analogues of Tetrahydrobiopterin [PDF]

open access: yes, 2017
In the vasculature, a physiologic production of nitric oxide (NO) is maintained by endothelial nitric oxide synthase (eNOS). Induction of inducible nitric oxide synthase (ÍNOS) under inflammatory conditions (e.g. septic shock) resulting in high levels of
Linscheid, Philippe   +4 more
core  

Structural features of halophilicity derived from the crystal structure of dihydrofolate reductase from the Dead Sea halophilic archaeon, Haloferax volcanii [PDF]

open access: yes, 1982
Background: The proteins of halophilic archaea require high salt concentrations both for stability and for activity, whereas they denature at low ionic strength. The structural basis for this phenomenon is not yet well understood.
Pieper, Ursula   +3 more
core   +5 more sources

Multifunctional PAMAM Dendrimers Carrying SAHA, 5‐FU, and a Therapeutic Gene for Targeted Co‐Delivery Toward Colorectal Cancer Cells

open access: yesBiotechnology Journal, Volume 19, Issue 11, November 2024.
Graphical Abstract and Lay Summary Colorectal cancer treatment (CRC) is challenged by multi‐drug resistance, where cancer cells become resistant to multiple drugs due to efflux pumps or enzymatic detoxification. This study proposes a multi‐pronged approach utilizing PAMAM dendrimers for targeted co‐delivery of genes and drugs to combat CRC.
Bünyamin Bulkurcuoğlu   +7 more
wiley   +1 more source

Widespread occurrence of glyceryl ether monooxygenase activity in rat tissues detected by a novel assay

open access: yesJournal of Lipid Research, 2007
An assay was set up for glyceryl ether monooxygenase activity in tissue samples using the novel substrate 1-O-pyrenedecyl-sn-glycerol and high-performance liquid chromatographic analysis of reaction mixtures with fluorescence detection, allowing robust ...
Ernst R. Werner   +4 more
doaj  

Sexual color ornamentation, microhabitat choice, and thermal physiology in the common wall lizard (Podarcis muralis)

open access: yesJournal of Experimental Zoology Part A: Ecological and Integrative Physiology, Volume 341, Issue 9, Page 1041-1052, November 2024.
Abstract Common wall lizards (Podarcis muralis) in Italy show a striking variation in body coloration across the landscape, with highly exaggerated black and green colors in hot and dry climates and brown and white colors in cool and wet climates. Males are more intensely colored than females, and previous work has suggested that the maintenance of ...
Maravillas Ruiz Miñano   +5 more
wiley   +1 more source

Home - About - Disclaimer - Privacy