Results 111 to 120 of about 13,736 (293)

The design and optimisation of novel human dihydrofolate reductase inhibitors for the management of proliferative disease [PDF]

, 2015
Tetrahydrofolate (THF) mediates DNA and RNA synthesis through production of purine and thymidylate precursors. During this process THF is reduced to the inactive dihydrofolate (DHF) and recycled back to the active DHF via a redox reaction, catalysed by ...
Portelli, Graziella, Shoemake, Claire
core  

Establishing pteridine metabolism in a progressive isogenic breast cancer cell model

Metabolomics, 2021
Lindsey Rasmussen, Zachary Foulks, Casey Burton, Honglan Shi   +3 more
semanticscholar   +1 more source

Design, Synthesis and Biological Evaluation of Novel Inhibitors of Trypanosoma brucei Pteridine Reductase 1

ChemMedChem, 2010
Genetic studies indicate that the enzyme pteridine reductase 1 (PTR1) is essential for the survival of the protozoan parasite Trypanosoma brucei. Herein, we describe the development and optimisation of a novel series of PTR1 inhibitors, based on benzo[d ...
D. Spinks, Han B. Ong, C. Mpamhanga, Emma Shanks, D. Robinson, I. Collie, K. Read, J. Frearson, P. Wyatt, R. Brenk, A. Fairlamb, I. Gilbert   +11 more
semanticscholar   +1 more source

In vitro Mutagenesis of Human Dihydropteridine Reductase at the Active Site and at Altered Sites Found in the Reductases of Deficient Children

Pteridines, 1996
A general procedure for in vitro site-directed mutagenesis of the wild-type dihydropteridine reductase gene has been used successfully to make eight mutant proteins.
Zhang Hong-Ping, Yang Nan, Armarego Wilfred L. F.   +2 more
doaj   +1 more source

Dihydropteroate synthase gene mutations in Pneumocystis and sulfa resistance [PDF]

, 2004
Pneumocystis pneumonia (PCP) remains a major cause of illness and death in HIV-infected persons. Sulfa drugs, trimethoprim-sulfamethoxazole (TMP-SMX) and dapsone are mainstays of PCP treatment and prophylaxis.
Atzori, C, Benfield, T, Crothers, KA, Haung, L, Helweg-Larsen, J, Miller, R, Rabodonirina, M   +6 more
core   +2 more sources

Black and White: Structural and Functional Aspects of Dermal Chromatophores of the Marbled Whiptail Lizard (Cnemidophorus Marmoratus) [PDF]

, 2004
The skin of reptiles is a complex organ with many sensory, regulatory and behavioral functions. Desert reptiles face a suite of challenges as their skin contacts hot-dry environmental surfaces.
Swan, James
core   +1 more source

Linkage of Pteridine Metabolism to Iron Homeostasis

Pteridines, 2004
Iron is an essential growth factor for the proliferation and differentiation of all living cells in being centrally involved in oxygen transport by hemoglobin and myoglobin, in electron transport during mitochondrial respiration as being a part of ...
Weiss Günter
doaj   +1 more source

PTERIDINES IN PHOTOSYNTHESIS [PDF]

Proceedings of the National Academy of Sciences, 1958
H. A. Nathan, R. C. Fuller, I. C. Anderson   +2 more
openaire   +3 more sources

Gene Regulation of Pteridine Reductase 1 in Leishmania Promastigotes and Amastigotes Using a Full-Length Antisense Construct

Iranian Journal of Parasitology, 2013
Background: Pteridine metabolic pathway is unusual features of Leishmania, which is necessary for the growth of parasite. Leishmania has evolved a complex and versatile pteridine salvage network which has the ability of scavenging a wide area of the ...
F Kheirandish, M Bandehpour, N Davoudi, N Mosaffa, S Dawood, B Kazemi, A Haghighi, A Khamesipour, H Masjedi, M Mohebali, F Mahboudi   +10 more
doaj   +2 more sources

Infrared absorption spectra of a series of 2, 6-diamino and 2-amino-6hydroxy-8-choroalkyl purines [PDF]

, 2003
8-haloalky purines were synthesized and infrared analysis (IR) carried out on them. The syntheses as well as the ill analyses are reported. The purines synthesized and studied include (i) 2,6-diamin-8-Chloromethyl purines, (ii) 2, 6-diamin-8-chlorethyl
I. M., Ejimadu
core