Results 11 to 20 of about 13,736 (293)

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity [PDF]

Molecules, 2017
Flavonoids have previously been identified as antiparasitic agents and pteridine reductase 1 (PTR1) inhibitors. Herein, we focus our attention on the chroman-4-one scaffold.
Alcantara, Laura M, Behrens, Birte, Borsari, Chiara, Cordeiro-da-Silva, Anabela, Costi, Maria Paola, Dello Iacono, Lucia, Di Pisa, Flavio, Ferrari, Stefania, Fontana, Vanessa, Freitas-Junior, Lucio H, Gul, Sheraz, Kuzikov, Maria, Landi, Giacomo, Mangani, Stefano, Moraes, Carolina B, Poehner, Ina, Pozzi, Cecilia, Santarem, Nuno, Santucci, Matteo, Wade, Rebecca C   +19 more
core   +3 more sources

Structure-based design and synthesis of antiparasitic pyrrolopyrimidines targeting pteridine reductase 1 [PDF]

Journal of Medicinal Chemistry, 2014
The treatment of Human African Trypanosomiasis remains a major unmet health need in sub-Saharan Africa. Approaches involving new molecular targets are important and pteridine reductase 1 (PTR1), an enzyme that reduces dihydrobiopterin in Trypanosoma spp.
Abedawn I. Khalaf, Addie M., Arcari J. T., Baker N., Barrett M. P., Barrett M. P., Bridges D. J., Brun R., Bursavich M. G., Carter N. S., Cavazzuti A., Colin J. Suckling, Colin L. Gibson, Creek D. J., Dawson A., Dincer S., Federica Giordani, Gangjee A., Gibson C. L., Gourley D. G., Judith K. Huggan, Kaspersen S. J., Keri L. Barrack, Kirsten Stewart, Le Brazidec J.-Y., Matovu E., Michael P. Barrett, Mohamed M. S., Mpamhanga C. P., Pui Ee Wong, Raz B., Sienkiewicz N., Simarro P. P., Spinks D., Tari L. W., Taylor E. C., Tessier P. R., Trzoss M., Tulloch L. B., William N. Hunter, Xie H., Zhu G.   +41 more
core   +5 more sources

Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties [PDF]

Future Medicinal Chemistry, 2015
BACKGROUND: Reactive oxygen species are associated with inflammation implicated in cancer, atherosclerosis and autoimmune diseases. The complex nature of inflammation and of oxidative stress suggests that dual-target agents may be effective in combating ...
Hadjipavlou-Litina, D, Marson, CM, Patsilinakos, A, Pontiki, E, Tran, TM   +4 more
core   +2 more sources

Pteridine levels and head weights are correlated with age and colony task in the honey bee, Apis mellifera [PDF]

PeerJ, 2016
Background. The age of an insect strongly influences many aspects of behavior and reproduction. The interaction of age and behavior is epitomized in the temporal polyethism of honey bees in which young adult bees perform nurse and maintenance duties ...
Frank D. Rinkevich, Joseph W. Margotta, Jean M. Pittman, James A. Ottea, Kristen B. Healy   +4 more
doaj   +3 more sources

Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

eLife, 2017
Nonribosomal peptides represent a large class of metabolites with pharmaceutical relevance. Pteridines, such as pterins, folates, and flavins, are heterocyclic metabolites that often serve as redox-active cofactors.
Hyun Bong Park, Corey E Perez, Karl W Barber, Jesse Rinehart, Jason M Crawford   +4 more
doaj   +2 more sources

Safety and efficacy of feed additives consisting of vitamin B₂ (98%) and vitamin B₂ (80%) produced with Bacillus subtilisCGMCC 7.449 for all animal species (Chifeng Pharmaceutical Co., Ltd.). [PDF]

EFSA J
Abstract Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) of EFSA was asked to deliver a scientific opinion on the safety and efficacy of vitamin B2 98% and vitamin B2 80% in the form of riboflavin produced by fermentation with a genetically modified strain of Bacillus ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Villa RE, Azimonti G, Bonos E, Christensen H, Durjava M, Dusemund B, Gehring R, Glandorf B, Kouba M, López-Alonso M, Marcon F, Nebbia C, Pechová A, Prieto-Maradona M, Röhe I, Theodoridou K, Mayo B, Cionci NB, Brozzi R, Galobart J, Holczknecht O, Manini P, Valeri P, Vettori MV, Pizzo F.   +25 more
europepmc   +2 more sources

Multitarget, Selective Compound Design Yields Potent Inhibitors of a Kinetoplastid Pteridine Reductase 1

Journal of Medicinal Chemistry, 2022
The optimization of compounds with multiple targets is a difficult multidimensional problem in the drug discovery cycle. Here, we present a systematic, multidisciplinary approach to the development of selective antiparasitic compounds.
Ina Poehner, A. Quotadamo, Joanna Panecka-Hofman, R. Luciani, M. Santucci, P. Linciano, G. Landi, F. Pisa, L. Iacono, C. Pozzi, S. Mangani, S. Gul, G. Witt, B. Ellinger, M. Kuzikov, N. Santarém, A. Cordeiro-da-Silva, Maria Paola Costi, A. Venturelli, R. Wade   +19 more
semanticscholar   +1 more source

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid

Acta Crystallographica Section F Structural Biology Communications, 2022
The high-resolution structure of Leishmania major pteridine reductase 1 in complex with its cofactor NADP+/NADPH and its substrate folic acid is reported. It provides insight into the active-site rearrangements that occur during the catalytic process.
L. Dello Iacono, F. Di Pisa, S. Mangani
semanticscholar   +1 more source

New Prenylated Indole Homodimeric and Pteridine Alkaloids from the Marine-Derived Fungus Aspergillus austroafricanus Y32-2

Marine Drugs, 2021
Chemical investigation of secondary metabolites from the marine-derived fungus Aspergillus austroafricanus Y32-2 resulted in the isolation of two new prenylated indole alkaloid homodimers, di-6-hydroxydeoxybrevianamide E (1) and dinotoamide J (2), one ...
Peihai Li, Mengqi Zhang, Haonan Li, Rongchun Wang, Hairong Hou, Xiaobin Li, Kechun Liu, Hao Chen   +7 more
semanticscholar   +1 more source

Environmental gradients predict the ratio of environmentally acquired carotenoids to self-synthesised pteridine pigments.

Ecology Letters, 2021
Carotenoids are important pigments producing integument colouration; however, their dietary availability may be limited in some environments. Many species produce yellow to red hues using a combination of carotenoids and self-synthesised pteridine ...
D. Stuart-Fox, Katrina J. Rankin, Adrian Lutz, Adam Elliott, A. Hugall, C. McLean, Iliana Medina   +6 more
semanticscholar   +1 more source