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Polarographic Study of Pteridines

Journal of Pharmaceutical Sciences, 1966
The electronegativity of the half-wave potentials of a series of pteridine congeners was found to be related to the substituent groups. The 2,4,7-triaminopteridines, 7-substituted 4-amino-2-aryl-6-pteridinecarboxarnides, and 4,7-diamino-2-aryl-6-pteridinecarboxamides were characterized, in that order, by decreasingly lower electronegative half-wave ...
M, Lapidus, M E, Rosenthale
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Pteridines and affective disorders

Acta Neuropsychiatrica, 2002
The pteridine tetrahydrobiopterin (BH4) is an essential cofactor in the biosynthesis of dopamine, (nor)epinephrine, serotonin and nitric oxide (NO). Furthermore, BH4 has a direct influence on release mechanisms of these neurotransmitters and on serotonin receptor binding activityimmunology.
Hoekstra, R (Rosa), Fekkes, Durk
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Biochemistry of the Pteridines

Angewandte Chemie International Edition in English, 1972
AbstractBiochemical information about the ubiquitous pteridines has become generally available only within the last fifteen years. This delay can be traced to the chemical lability of these compounds and their small concentrations in organisms. New methods of isolation and isotopic techniques have provided data on the biosynthesis, anabolism, and ...
H, Rembold, W L, Gyure
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Pteridine, XLI. Zur Synthese von Pteridin‐N‐8‐ribosiden

Chemische Berichte, 1971
AbstractZur Synthese der ersten Pteridin‐N‐8‐riboside (912) werden 5‐Nitro‐4‐ribofuranosylamino‐pyrimidine (14) zunächst zu den 5‐Aminoderivaten (5, 6) reduziert, diese dann mit Glyoxyl‐säureester kondensiert (7, 8) und 7, 8 anschließend cyclisiert. Zur Charakterisierung der Produkte dienen UV‐ und NMR‐Spektren.
Hartmut Rokos, Wolfgang Pfleiderer
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Pteridine studies. Part XXXIV. Nucleophilic addition reactions of pteridine-2-thiol and 2-(methylthio)pteridine

Journal of the Chemical Society C: Organic, 1968
Pteridine-2-thiol was reduced by sodium borohydride to the 3,4-dihydro-derivative. Pteridine-2-thiol also reacted readily with sodium hydrogen sulphite and the following potentially carbanionic (‘Michael’) reagents; acetylacetone, ethyl acetoacetate, dimedone, and phloroglucinol.
Adrien Albert, John J. McCormack
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Pteridine, XVI. Zur Synthese und Struktur von Pteridin‐glykosiden

Chemische Berichte, 1962
AbstractAusgehend von 2‐Amino‐4‐alkoxy‐7‐oxo‐dihydropteridinen wurden mit Halogenzuckern in siedendem Xylol und bei Gegenwart von Silbercarbonat Pteridin‐glykoside erhalten. Diese Produkte zeigen neben der erwarteten Säurelabilität der Glykosidbindung auch eine große Hydrolysenempfindlichkeit gegenüber Alkalien, was ebenso wie die UV ...
Wolfgang Pfleiderer, Rolf Lohrmann
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A Synthesis of Pteridine

Nature, 1948
ALTHOUGH many derivatives of pteridine, both natural and synthetic, are known, the parent substance pteridine (I) does not appear to have been described. This substance has now been prepared by the condensation of 4 : 5-diaminopyrimidine with glyoxal bisulphite.
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