Results 241 to 250 of about 13,736 (293)
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ACS Infectious Diseases, 2019
Cycloguanil is a known dihydrofolate-reductase (DHFR) inhibitor, but there is no evidence of its activity on pteridine reductase (PTR), the main metabolic bypass to DHFR inhibition in trypanosomatid parasites.
G. Landi +11 more
semanticscholar +1 more source
Cycloguanil is a known dihydrofolate-reductase (DHFR) inhibitor, but there is no evidence of its activity on pteridine reductase (PTR), the main metabolic bypass to DHFR inhibition in trypanosomatid parasites.
G. Landi +11 more
semanticscholar +1 more source
Journal of Electroanalytical Chemistry and Interfacial Electrochemistry, 1975
Summary Over the pH range 1–12, pteridine is reduced at the dropping mercury electrode (DME) and pyrolytic graphite electrode (PGE) by way of three polarographic or voltammetric processes. The first, least negative process, is a reversible 2 e -2H + reduction of pteridine to 5,8-dihydropteridine.
David L. McAllister, Glenn Dryhurst
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Summary Over the pH range 1–12, pteridine is reduced at the dropping mercury electrode (DME) and pyrolytic graphite electrode (PGE) by way of three polarographic or voltammetric processes. The first, least negative process, is a reversible 2 e -2H + reduction of pteridine to 5,8-dihydropteridine.
David L. McAllister, Glenn Dryhurst
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Therapeutic potential of pteridine derivatives: A comprehensive review
Medicinal research reviews (Print), 2018Pteridines are aromatic compounds formed by fused pyrazine and pyrimidine rings. Many living organisms synthesize pteridines, where they act as pigments, enzymatic cofactors, or immune system activation molecules. This variety of biological functions has
Violeta Carmona-Martínez +5 more
semanticscholar +1 more source
Pteridines and affective disorders
Acta Neuropsychiatrica, 2002The pteridine tetrahydrobiopterin (BH4) is an essential cofactor in the biosynthesis of dopamine, (nor)epinephrine, serotonin and nitric oxide (NO). Furthermore, BH4 has a direct influence on release mechanisms of these neurotransmitters and on serotonin receptor binding activityimmunology.
Durk Fekkes, R. Hoekstra
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Reductone and the Synthesis of Pteridines
Nature, 1948As we have pointed out1 that the 3-carbon atom unit comprising the ring atoms 6 and 7 and the exocyclic carbon atom (indicated in heavy type) in pteroic acid (I) might be derived from a triose, 3-phosphoglyceraldehyde and phosphodihydroxyacetone being specifically mentioned, the suggestion by O‘Meara, McNally and Nelson2 that the strongly reducing non ...
H. S. Forrest, James Walker
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Helvetica Chimica Acta, 2003
AbstractThe low solubility of pterins can drastically be improved by N2‐acylation or formation of the N2‐[(dimethylamino)methylene] derivatives. Both types of compounds can be alkylated under Mitsunobu conditions to form from N2‐acylpterins (see 2 and 3) and their derivatives (see 5, 6, 8, 9, 11, 13, 15, and 17) selectively the O4‐alkyl derivatives 22 ...
Wolfgang Pfleiderer, Qizheng Yao
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AbstractThe low solubility of pterins can drastically be improved by N2‐acylation or formation of the N2‐[(dimethylamino)methylene] derivatives. Both types of compounds can be alkylated under Mitsunobu conditions to form from N2‐acylpterins (see 2 and 3) and their derivatives (see 5, 6, 8, 9, 11, 13, 15, and 17) selectively the O4‐alkyl derivatives 22 ...
Wolfgang Pfleiderer, Qizheng Yao
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Seeing red: pteridine-based colour and male quality in a dragon lizard
Biological Journal of the Linnean Society, 2018The animal kingdom is represented by a spectacular diversity of colourful species. However, for particular groups, such as lizards, we still know little about the nature of these colours and what they might signal about individual quality.
T. Merkling +3 more
semanticscholar +1 more source
Polarographic Study of Pteridines
Journal of Pharmaceutical Sciences, 1966The electronegativity of the half-wave potentials of a series of pteridine congeners was found to be related to the substituent groups. The 2,4,7-triaminopteridines, 7-substituted 4-amino-2-aryl-6-pteridinecarboxarnides, and 4,7-diamino-2-aryl-6-pteridinecarboxamides were characterized, in that order, by decreasingly lower electronegative half-wave ...
Marvin E Rosenthale, Milton Lapidus
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Nature, 1948
ALTHOUGH many derivatives of pteridine, both natural and synthetic, are known, the parent substance pteridine (I) does not appear to have been described. This substance has now been prepared by the condensation of 4 : 5-diaminopyrimidine with glyoxal bisulphite.
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ALTHOUGH many derivatives of pteridine, both natural and synthetic, are known, the parent substance pteridine (I) does not appear to have been described. This substance has now been prepared by the condensation of 4 : 5-diaminopyrimidine with glyoxal bisulphite.
openaire +3 more sources
Journal of Agricultural and Food Chemistry, 2016
New Zealand manuka honey is well-known for its unique antibacterial activity. Due to its high price and limited availability, this honey is often subject to honey fraud.
Nicole Beitlich +4 more
semanticscholar +1 more source
New Zealand manuka honey is well-known for its unique antibacterial activity. Due to its high price and limited availability, this honey is often subject to honey fraud.
Nicole Beitlich +4 more
semanticscholar +1 more source