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A New Synthesis of Pteridines.
ChemInform, 2006AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ming Xu, Andrea Vasella
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1984
Publisher Summary This chapter covers the recent developments, synthetic approaches, and biochemical aspects of pteridines and folates.. The numbering system follows the IUPAC rules; however, the central C=C bond may be substituted. The 2,4(1H, H)-pteridinediones derivatives are called “lumazines.” Reduced compounds are indicated by the prefixes ...
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Publisher Summary This chapter covers the recent developments, synthetic approaches, and biochemical aspects of pteridines and folates.. The numbering system follows the IUPAC rules; however, the central C=C bond may be substituted. The 2,4(1H, H)-pteridinediones derivatives are called “lumazines.” Reduced compounds are indicated by the prefixes ...
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, 2016
We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20 °C).
Yusuke Sato +5 more
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We report on a fluorescent pteridine derivative modified with a guanidino group for the selective detection of an orphan guanine in RNA duplexes with a dissociation constant of 31 ± 7 nM (pH 7.0, T = 20 °C).
Yusuke Sato +5 more
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The biosynthesis of pteridines. Part V. The synthesis of riboflavin from pteridine precursors
Journal of the Chemical Society C: Organic, 1968The synthesis and reactions of various 8-substituted lumazine derivatives are described. In particular, it is shown that these compounds readily undergo hydration, and that the resulting carbinol-amines can take part in reactions which involve ring-opening in the pyrazine ring.
Thomas Rowan, H. C. S. Wood
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Journal of Medicinal Chemistry, 2012
The upregulation of pteridine reductase (PTR1) is a major contributor to antifolate drug resistance in Leishmania spp., as it provides a salvage pathway that bypasses dihydrofolate reductase (DHFR) inhibition. The structure-based optimization of the PTR1
P. Corona +14 more
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The upregulation of pteridine reductase (PTR1) is a major contributor to antifolate drug resistance in Leishmania spp., as it provides a salvage pathway that bypasses dihydrofolate reductase (DHFR) inhibition. The structure-based optimization of the PTR1
P. Corona +14 more
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Pteridine detection in urine: the future of cancer diagnostics?
Biomarkers in Medicine, 2013Pteridines as biomarkers The aim of developing noninvasive cancer screening techniques that can lead to both diag nosis and prognosis is rapidly gaining popular ity in cancer biomarker research and discov ery.
Yinfa Ma, Casey Burton
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The Monosubstituted Pteridines
Nature, 1954THE synthesis of a wide variety of monosubstituted pteridines was begun in this Department in 1949, in order to provide less complex pteridines than occur in Nature. We are using the new material to investigate the connexion between constitution and physico-chemical properties (particularly solubility, ionization constants, stability to hydrolysis ...
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Journal of the Chemical Society C: Organic, 1968
Pteridine-2-thiol was reduced by sodium borohydride to the 3,4-dihydro-derivative. Pteridine-2-thiol also reacted readily with sodium hydrogen sulphite and the following potentially carbanionic (‘Michael’) reagents; acetylacetone, ethyl acetoacetate, dimedone, and phloroglucinol.
John J. McCormack, Adrien Albert
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Pteridine-2-thiol was reduced by sodium borohydride to the 3,4-dihydro-derivative. Pteridine-2-thiol also reacted readily with sodium hydrogen sulphite and the following potentially carbanionic (‘Michael’) reagents; acetylacetone, ethyl acetoacetate, dimedone, and phloroglucinol.
John J. McCormack, Adrien Albert
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Journal of Medicinal Chemistry, 2011
Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify new molecules with specificity for PTR1, we carried out
S. Ferrari +13 more
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Folate analogue inhibitors of Leishmania major pteridine reductase (PTR1) are potential antiparasitic drug candidates for combined therapy with dihydrofolate reductase (DHFR) inhibitors. To identify new molecules with specificity for PTR1, we carried out
S. Ferrari +13 more
semanticscholar +1 more source