Identification of Kaurane-Type Diterpenes as Inhibitors of Leishmania Pteridine Reductase I
Molecules, 2021 The current treatments against Leishmania parasites present high toxicity and multiple side effects, which makes the control and elimination of leishmaniasis challenging.
Chonny Herrera-Acevedo +5 more
semanticscholar +1 more source
Molecules, 2021 The parasite Trypanosoma brucei (T. brucei) is responsible for human African trypanosomiasis (HAT) and the cattle disease “Nagana” which to this day cause severe medical and socio-economic issues for the affected areas in Africa.
K. Possart +4 more
semanticscholar +1 more source
SHILAP, 2021 The wing colours and patterns of the genus Zygaena are limited and mainly red and black. This fact creates problems to distinguish closely related species by visual inspection.
G. Bunetebarth, A. Nahirnic-Beshkova
doaj +1 more source
Malignant Mixed Irido-Melanophoroma in a Betta splendens with Concurrent Mycobacterium chelonae Isolation-A Case Report. [PDF]
J Fish DisABSTRACT A 10‐month‐old intact male blue Siamese fighting fish (Betta splendens) was presented to the Purdue University Small Animal Hospital with multiple bilateral masses on the caudal flank. Comprehensive evaluation using impression cytology, histopathology and transmission electron microscopy (TEM) revealed a tumour composed of a mixed‐cell ...
Yu ZA, Corriveau LA, Messick JB.
europepmc +2 more sources
Pteridines in the Assessment of Neoplasia [PDF]
cclm, 1982 Biological processes which might explain the association of pteridine excretion with proliferation are still unknown. Difficulties in the analysis and the determination of naturally occurring pteridines are described. The best quantitative estimations were achieved when measurement of non-reduced forms was attempted.
HAUSEN, A., Wachter, H.
openaire +3 more sources
Antitumor studies. Part 4: Design, synthesis, antitumor activity, and molecular docking study of novel 2-substituted 2-deoxoflavin-5-oxides, 2-deoxoalloxazine-5-oxides, and their 5-deaza analogs [PDF]
, 2008 Various novel 10-alkyl-2-deoxo-2-methylthioflavin-5-oxides and their 2-alkylamino derivatives were prepared by facile nitrosative cyclization of 6-(N-alkylanilino)-2-methylthiopyrimidin-4(3H)-ones followed by nucleophilic replacement of the 2-methylthio ...
Ali, Hamed I. +2 more
core +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, [Zn(C8H5N5O3)(C12H8N2)(H2O)]·3H2O, a tridentate 2-amino-7-methyl-4-oxidopteridine-6-carboxylate ligand, a bidentate ancillary 1,10-phenanthroline (phen) ligand and a water molecule complete a distorted octahedral coordination ...
Siddhartha S. Baisya +2 more
doaj +1 more source
Directed search for diuretics among 6-substituted pteridine-2,4,7(1H,3H,8H)-triones
Medičnì Perspektivi, 2022 Directed search for biologically active compounds among heterocycles still remains a relevant area of medical chemistry. Among the significant number of heterocyclic compounds, pteridines deserve special attention.
K.V. Sokolova +3 more
doaj +1 more source
Diversity oriented synthesis : substitution at C5 in unreactive pyrimidines by Claisen rearrangement and reactivity in nucleophilic substitution at C2 and C4 in pteridines and pyrido[2,3-d]pyrimidines [PDF]
, 2011 Diversity oriented synthesis of fused pyrimidines leads to scaffolds with many biological activities. In the case of the preparation of pyrido[2,3-d]pyrimidines from 2-alkylthiopyrimidines, the formation of a new carbon-carbon bond at C5 is required, a ...
Adcock, Jonathan Paul +3 more
core +1 more source
ITRAQ Proteomic Analysis of Yellow and Black Skin in Jinbian Carp (Cyprinus carpio)
Life, 2020 Colors are important phenotypic traits for fitness under natural conditions in vertebrates. Previous studies have reported several functional genes and genetic variations of pigmentation, but the formation mechanisms of various skin coloration remained ...
Xiangchen Ye +10 more
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