Results 31 to 40 of about 10,444 (253)
Glyceryl-Ether Monooxygenase [EC 1.14.16.5J Part VIII. Probing the Nature of the Active Site
Pteridines, 1995 The V /K kinetic parameters for glyceryl-ether monooxygenase with 3-1 '-n-alkoxypropane-I,2-diols having alkyl sidechains varying from Cll to C22 (lb-k, 2a and b, and 3d) were determined. Maximum activity was found with the CI6 ethers, dropping almost to
Taguchi Hiroyasu +2 more
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Acta Chimica Slovenica, 2020 A simple and effective method for the synthesis of unknown 1-methyl-7-arylfuro[3,2-g]pteridine-2,4(1H,3H)-diones by dehydration of the corresponding 1-methyl-6-phenacyl-pteridine-2,4,7(1H,3H,8H)-triones is reported in the article. It was shown that their
Maxim Stanislavovich Kazunin +4 more
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Pteridine-2,4-diamine derivatives as radical scavengers and inhibitors of lipoxygenase that can possess anti-inflammatory properties [PDF]
, 2015 BACKGROUND: Reactive oxygen species are associated with inflammation implicated in cancer, atherosclerosis and autoimmune diseases. The complex nature of inflammation and of oxidative stress suggests that dual-target agents may be effective in combating ...
Hadjipavlou-Litina, D +4 more
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pteridines, 1999 Summary A series of new 6-substituted 2,4-diaminopteridines (3-23) and pterins (26-43) have been synthesized by nucleophilic displacement reactions at the side chain of 6-bromomethyl-2,4-diaminopteridine (2) and 6- bromomethylpterin (25) using various types of 0-, N- and S-nucleophiles.
Hermann Traub, Wolfgang Pfleiderer
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Trypanosoma brucei DHRF-TS revisited:characterisation of a bifunctional and highly unstable recombinant dihydrofolate reductase-thymidylate synthase [PDF]
, 2016 Bifunctional dihydrofolate reductase–thymidylate synthase (DHFR-TS) is a chemically and genetically validated target in African trypanosomes, causative agents of sleeping sickness in humans and nagana in cattle.
A Dawson +63 more
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Pteridines, 1995 Treatment of L-biopterin (I) with N,N-dimethyformamide dimethyl- (or diethyl)acetal and then with acetic anhydride in pyridine gave 1',2'-di-O-acetyl-N'-(N,N-dimethylaminomethylene)-L-biopterin (4), which was converted by the Mitsunobu reaction into 3-methyl (5) and 3-p-nitrophenetyl derivatives (7). The protective groups on the side chain diols and N2
Hanaya Tadashi +5 more
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Age-dependance of pteridines in the malaria vector, Anopheles stephensi
Pteridines, 2017 Determining the accurate age of malaria vectors is crucial to measure the risk of malaria transmission. A group of fluorescent chemicals derived from a pyrimidine-pyrazine ring structure known as pteridines from the head, thorax and whole body of adult ...
Edalat Hamideh +2 more
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First Synthesis of Asperopterin A, an Isoxanthopterin Glycoside from Aspergillus Oryzae [PDF]
, 2013 The key precursor, N-2-(N,N -dimethylaminomethylene)-6-hydroxymethyl-8-methyl-3-[2-(4-nitrophenyl)ethyl]-7-xanthopterin (16) was efficiently prepared from 2,5-diamino-6-methylamino-3H-pyrimidin-4-one (5) and ethyl 3-(tert-butyldimethylsilyloxy)-2 ...
Hanaya, Tadashi, Yamamoto, Hiroshi
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Pteridines, 1998 A simple direct method for the synthesis of lumazine-6,7-diamines (9, 25-27) from uracil-5,6-diamines (10-13) and methyl cyanoformimidate (24) was found. Various nucleophilic displacement reactions were performed with 7-chloro-1,3-dimethyllumazine-6-amine (17) leading to new 6,7-disubstituted 1,3- dimethyllumazine derivatives (18-23).
Abou-Hadeed Khaled, Pfleiderer Wolfgang
openaire +3 more sources
Blocked dihydropteridines as nitric oxide synthase activators [PDF]
, 2010 It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS).
Daff, Simon +5 more
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