Results 41 to 50 of about 13,736 (293)
1H-Benzo[g]pteridine-2,4-dione
IUCrData, 2023 The structure of the title compound, C10H6N4O2, reported by Smalley et al. [(2021). Cryst. Growth Des. 22, 524–534] from powder diffraction data and 15N NMR spectroscopy, is confirmed using low-temperature data from a twinned crystal. The tautomer in the
Rao M. Uppu, Frank R. Fronczek
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Pteridines in the Control of Pigmentation
Journal of Investigative Dermatology, 1997 The influence of UVB irradiation on the metabolic pathway for the production of L-tyrosine from L-phenylalanine in the human epidermis has been examined in 12 healthy volunteers with photo skin types I-VI (Fitzpatrick classification). This metabolic pathway involves the induction of GTP-cyclohydrolase 1 (GTP-CH-1), the rate-limiting enzyme for de novo ...
Christa Körner +6 more
openaire +3 more sources
Exploring the scope of DBU-promoted amidations of 7-carboxymethyl-pterin [PDF]
, 2020 Pteridines are an important heterocycle often used in the development of pharmaceutically relevant compounds, and in the field of supramolecular chemistry.
Bockman, Anna
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Tetrahydrobiopterin analogues with NO-dependent pulmonary vasodilator properties [PDF]
, 2011 Reduced NO levels due to the deficiency of tetrahydrobiopterin (BH4) contribute to impaired vasodilation in pulmonary hypertension Due to the chemically unstable nature of BH4 it was hypothesised that oxidatively stable analogues of BR, would be able to ...
Gibson, Colin +4 more
core +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2019 Leishmaniasis is a tropical disease found in more than 90 countries. The drugs available to treat this disease have nonspecific action and high toxicity.
Bárbara Velame Ferreira Teixeira +7 more
semanticscholar +1 more source
Glyceryl-Ether Monooxygenase [EC 1.14.16.5J Part VIII. Probing the Nature of the Active Site
Pteridines, 1995 The V /K kinetic parameters for glyceryl-ether monooxygenase with 3-1 '-n-alkoxypropane-I,2-diols having alkyl sidechains varying from Cll to C22 (lb-k, 2a and b, and 3d) were determined. Maximum activity was found with the CI6 ethers, dropping almost to
Taguchi Hiroyasu +2 more
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Molecules, 2019 Pteridine reductase 1 (PTR1) is a trypanosomatid multifunctional enzyme that provides a mechanism for escape of dihydrofolate reductase (DHFR) inhibition. This is because PTR1 can reduce pterins and folates.
M. P. Kimuda +3 more
semanticscholar +1 more source
Dendritic Molecular Baskets for Selective Binding of Toxic Methotrexate
Angewandte Chemie, Volume 137, Issue 9, February 24, 2025.Dendritic molecular baskets are biocompatible cavitands capable of including toxic methotrexate (MTX) in their aromatic cavity. The binding is chemoselective with the complex forming in competitive cell media. With the unique mode of recognition and modular structure, dendritic baskets are leading candidates for developing effective antidotes against ...
Nitesh Kumar +8 more
wiley +2 more sources
Analysis by RNA-seq of transcriptomic changes elicited by heat shock in Leishmania major [PDF]
, 2019 Besides their medical relevance, Leishmania is an adequate model for studying post-transcriptional mechanisms of gene expression. In this microorganism, mRNA degradation/stabilization mechanisms together with translational control and post-translational ...
Aguado, Begoña +5 more
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Acta Chimica Slovenica, 2020 A simple and effective method for the synthesis of unknown 1-methyl-7-arylfuro[3,2-g]pteridine-2,4(1H,3H)-diones by dehydration of the corresponding 1-methyl-6-phenacyl-pteridine-2,4,7(1H,3H,8H)-triones is reported in the article. It was shown that their
Maxim Stanislavovich Kazunin +4 more
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