Results 51 to 60 of about 13,736 (293)

First Synthesis of a Natural Isoxanthopterin Glycoside, Asperopterin-A [PDF]

, 2012
The key precursor, N-2-(N,N-dimethylaminomethylene)-6-hydroxymethy1-8-methyl-3[2-(4-nitrophenypethyl]-7-xanthopterin (9) was efficiently prepared from 2,5-diamino-6-methylam1no-3H-pyrimidin-4-one (3) and ethyl 3-(tert-butyldimethylsilyloxy)-2 ...
Ejiri, Kazumasa, Hanaya, Tadashi, Yamamoto, Hiroshi   +2 more
core   +1 more source

Synthesis and studies molecular docking of some new thioxobenzo[g]pteridine derivatives and 1,4-dihydroquinoxaline derivatives with glycosidic moiety

Journal of Taibah University for Science, 2018
The present work is mainly dedicated to heterocyclic compounds as well as S-glycoside. 1,4-dihydroquinoxaline derivatives 3 were obtained from the reaction 2 with carbon disulfide in presence of potassium hydroxide.
A. Ghoneim, Nadia Ali Ahmed Elkanzi, R. Bakr   +2 more
semanticscholar   +1 more source

Age-dependance of pteridines in the malaria vector, Anopheles stephensi

Pteridines, 2017
Determining the accurate age of malaria vectors is crucial to measure the risk of malaria transmission. A group of fluorescent chemicals derived from a pyrimidine-pyrazine ring structure known as pteridines from the head, thorax and whole body of adult ...
Edalat Hamideh, Akhoundi Mohammad, Basseri Hamidreza   +2 more
doaj   +1 more source

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery

ACS Omega, 2017
Pteridine reductase-1 (PTR1) is a promising drug target for the treatment of trypanosomiasis. We investigated the potential of a previously identified class of thiadiazole inhibitors of Leishmania major PTR1 for activity against Trypanosoma brucei (Tb ...
P. Linciano, Alice Dawson, Ina Pöhner, David M. Costa, Monica S. Sá, A. Cordeiro-da-Silva, R. Luciani, Sheraz Gul, G. Witt, B. Ellinger, M. Kuzikov, P. Gribbon, Jeanette Reinshagen, M. Wolf, Birte Behrens, V. Hannaert, Paulus Michels, E. Nerini, C. Pozzi, F. Di Pisa, G. Landi, N. Santarém, S. Ferrari, Puneet Saxena, S. Lazzari, G. Cannazza, L. Freitas-Junior, C. Moraes, B. Pascoalino, L. Alcântara, C. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Müller, Rebecca C. Wade, William N. Hunter, S. Mangani, Luca Costantino, M. Costi   +38 more
semanticscholar   +1 more source

In Silico and In Vitro Search for Dual Inhibitors of the Trypanosoma brucei and Leishmania major Pteridine Reductase 1 and Dihydrofolate Reductase

Molecules, 2023
The parasites Trypanosoma brucei (Tb) and Leishmania major (Lm) cause the tropical diseases sleeping sickness, nagana, and cutaneous leishmaniasis. Every year, millions of humans, as well as animals, living in tropical to subtropical climates fall victim
Katharina Possart, Fabian C. Herrmann, Joachim Jose, Thomas J. Schmidt   +3 more
doaj   +1 more source

Sequence-Based Mapping and Genome Editing Reveal Mutations in Stickleback Hps5 Cause Oculocutaneous Albinism and the casper Phenotype. [PDF]

, 2017
Here, we present and characterize the spontaneous X-linked recessive mutation casper, which causes oculocutaneous albinism in threespine sticklebacks (Gasterosteus aculeatus).
Hart, James C, Miller, Craig T
core   +2 more sources

Expression patterns of melanin‐related genes are linked to crypsis and conspicuousness in a pumpkin toadlet

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Colour signals play pivotal roles in different communication systems, and the evolution of these characters has been associated with behavioural ecology, integumentary production processes and perceptual mechanisms of the species involved. Here, we present the first insight into the molecular and histological basis of skin colour polymorphism ...
Juliane P. C. Monteiro, Heike Pröhl, Mariana L. Lyra, Andrés E. Brunetti, Eli C. de Nardin, Thais H. Condez, Célio F. B. Haddad, Ariel Rodríguez   +7 more
wiley   +1 more source

Inhibitory Effects of Pteridines on the Cytochrome P-450 Enzyme System

Pteridines, 1997
The effects of 17 different pteridine derivatives on rat liver microsomal cytochrome P-450 catalyzed degradation of aminoantipyrin were studied.
Horejsi Renate, Daczki Jürgen, Mölller Reinhard, Öttl Karl, Vrecko Karoline, Reibnegger Gilbert   +5 more
doaj   +1 more source

Blocked dihydropteridines as nitric oxide synthase activators [PDF]

, 2010
It has been shown that 6-acetyl-7,7-dimethyl-5,6,7,8-tetrahydropteridin-4(3H)-one can act as a competent cofactor for the production of nitric oxide by neuronal nitric oxide synthase (nNOS).
Daff, Simon, Gazur, Ben, Gibson, C.L., McInnes, Craig R., Morthala, Raghavendar R., Suckling, C.J.   +5 more
core  

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs [PDF]

, 2016
Flavonoids represent a potential source of new antitrypanosomatidic leads. Starting from a library of natural products, we combined target-based screening on pteridine reductase 1 with phenotypic screening on Trypanosoma brucei for hit identification ...
Anabela Cordeiro-da-Silva, Annalisa Tait, Bernhard Ellinger, Bifeld E., Birte Behrens, Catarina Baptista, Cecilia Pozzi, Chiara Borsari, Eugenia Bifeld, Federica Pellati, Flavio Di Pisa, Gesa Witt, Giacomo Landi, Ina Poehner, Jeanette Reinshagen, Joachim Clos, José M Alunda, Juan Torrado, Julia Eick, Luca Costantino, Lucia Dello Iacono, Manfred Kohler, Maria Kuzikov, Maria Paola Costi, Markus Wolf, María D. Jiménez-Antón, María J. Corral, Matteo Trande, Nuno Santarem, Oliver Keminer, Paloma Tejera Nevado, Philip Gribbon, Rebecca C. Wade, Rosaria Luciani, Sereno D., Sheraz Gul, Stefan Henrich, Stefania Ferrari, Stefano Mangani   +38 more
core   +30 more sources