Results 61 to 70 of about 10,390 (256)

Genome mining unearths a hybrid nonribosomal peptide synthetase-like-pteridine synthase biosynthetic gene cluster

eLife, 2017
Nonribosomal peptides represent a large class of metabolites with pharmaceutical relevance. Pteridines, such as pterins, folates, and flavins, are heterocyclic metabolites that often serve as redox-active cofactors.
Hyun Bong Park, Corey E Perez, Karl W Barber, Jesse Rinehart, Jason M Crawford   +4 more
doaj   +1 more source

Gene expression in Leishmania is regulated predominantly by gene dosage [PDF]

, 2017
Leishmania tropica, a unicellular eukaryotic parasite present in North and East Africa, the Middle East, and the Indian subcontinent, has been linked to large outbreaks of cutaneous leishmaniasis in displaced populations in Iraq, Jordan, and Syria. Here,
Berriman, Matthew, Beverley, Stephen M., Cotton, James A., Durrant, Caroline, Grigg, Michael E., Iantorno, Stefano A., Khan, Asis, Myler, Peter, Ouellette, Marc, Sacks, David L., Sanders, Mandy J., Warren, Wesley C., Weiss, Louis M.   +12 more
core   +3 more sources

Occurrence and significance of folic acid

Pteridines, 2018
Folic acid is a naturally occurring pteridine, which was originally isolated from plants. Folic acid (pteroyl-glutamic acid) is composed of pteridine (6-methylptero), p-aminobenzoic acid (PABA) and glutamic acid.
Cieślik Ewa, Cieślik Iwona
doaj   +1 more source

Urinary Oxidative Damage Markers and Their Association with Obesity-Related Metabolic Risk Factors

Antioxidants, 2022
Oxidative damage and inflammation are possible mechanisms linking obesity to diabetes and related complications. This study investigates the levels of oxidative damage markers in the urine of community free-living subjects with increased prevalence of ...
Salah Gariballa, Abderrahim Nemmar, Ozaz Elzaki, Nur Elena Zaaba, Javed Yasin   +4 more
doaj   +1 more source

Microbial profile of the appendix niche in acute appendicitis: a novel sampling approach

FEBS Open Bio, Volume 15, Issue 12, Page 2001-2020, December 2025.
This study utilized a novel sampling method, ERAT (i.e. endoscopic retrograde appendicitis treatment)‐guided lumen aspiration, to obtain samples from the appendix, and shotgun metagenomic sequencing was performed for in situ characterization of the appendix microbiome in patients with acute appendicitis.
Huimin Ma, Mingfei Wang, Yanhu Feng, Wanqi Zhang, Wenbo Wang, Yanfeng Xie, Guixiang Kong, Jie Feng, Pengfei Wang, Qi Wang, Xiaojun Huang   +10 more
wiley   +1 more source

Pteridines in the Control of Pigmentation

Journal of Investigative Dermatology, 1997
The influence of UVB irradiation on the metabolic pathway for the production of L-tyrosine from L-phenylalanine in the human epidermis has been examined in 12 healthy volunteers with photo skin types I-VI (Fitzpatrick classification). This metabolic pathway involves the induction of GTP-cyclohydrolase 1 (GTP-CH-1), the rate-limiting enzyme for de novo ...
Schallreuter, Karin U., Schulz-Douglas, Vincent, Bünz, Andreas, Beazley, Wayne, Körner, Christa   +4 more
openaire   +2 more sources

Applications of QSPR and Machine Learning in Molecular Photonics

Advanced Optical Materials, Volume 13, Issue 33, November 25, 2025.
Quantitative structureproperty relationships (QSPR) and machine learning (ML) are transforming photochemistry by enabling pre‐synthetic screening of photoactive molecules. This review outlines advances in data‐driven discovery of optical materials and functional dyes, identifies effective descriptors and models for photophysical processes, and provides
Andrey A. Buglak, Platon P. Chebotaev, Mikhail A. Filatov   +2 more
wiley   +1 more source

The Physarum polycephalum genome reveals extensive use of prokaryotic two-component and metazoan-type tyrosine kinase signaling [PDF]

, 2015
Physarum polycephalum is a well-studied microbial eukaryote with unique experimental attributes relative to other experimental model organisms. It has a sophisticated life cycle with several distinct stages including amoebal, flagellated, and plasmodial
et al,, Fronick, Catrina, Fulton, Lucinda, Minx, Pat, Tomlinson, Chad, Warren, Wesley C, Wilson, Richard K   +6 more
core   +9 more sources

1,3,7-Trimethyl-2,4-dioxo-1,2,3,4-tetrahydropteridine-6-carboxylic acid hemihydrate

Acta Crystallographica Section E, 2010
In the title compound, C10H10N4O4·0.5H2O, the two rings of the pteridine system are nearly coplanar [dihedral angle = 4.25 (9)°]. The atoms of the carboxyl group are also coplanar with the pteridine unit [r.m.s. deviation from
Miguel N. Moreno-Carretero, Fátima M. Linares-Ordóñez, Sonia B. Jiménez-Pulido, René Faure, Nuria A. Illán-Cabeza   +4 more
doaj   +1 more source

Neopterin as a Tool for Primate Ecoimmunology: Current Knowledge, Practical Application, and New Directions From Captivity to the Wild

American Journal of Primatology, Volume 87, Issue 10, October 2025.
Neopterin is a sensitive and specific biomarker of intracellular pathogen infection and chronic inflammation, and affected by environmental, life‐history, and sex‐contextual factors. This review offers best‐practice guidelines and practical advice on sample collection, storage, and analysis in primates when used for ecoimmunological conservation and ...
Verena Behringer, Caroline Deimel
wiley   +1 more source