Results 61 to 70 of about 5,912 (161)

Improving Proteolysis‐Targeting Chimera Delivery by Targeting Key Biomarkers in Tumor Endocytosis Pathways

MedComm – Biomaterials and Applications, Volume 5, Issue 3, September 2026.
The image illustrates how PROTACs utilize endocytosis, mediated by cell surface proteins, to overcome bioavailability limitations and enable efficient intracellular delivery. ABSTRACT Proteolysis‐targeting chimeras (PROTACs) are promising therapeutic agents for targeted protein degradation via the ubiquitin‐proteasome system; however, their clinical ...
Huahua Chen, Jiayan Jiao, Huiling Yang, Tao He   +3 more
wiley   +1 more source

pH-Related and Site-Specific Excited-State Proton Transfer from Pterin to Acetate

, 2014
The pH-related fluorescence quenching mechanism of 2-amino-4-hydroxypteridine (pterin), a biologic functional molecule, in the presence of acetate ion has been fully investigated for the first time. Using a combined experimental and theoretical approach,
Yang, Dapeng, Lei Liu, Peng Li, Li, Peng, Liu, Lei, Dapeng Yang   +5 more
core   +1 more source

Synthesis of Chalcone‐Sulfonamide Hybrids as Antibacterial, Antioxidant, and Anti‐Inflammatory Agents With Comprehensive In Silico and ADMET Profiling

ChemistryOpen, Volume 15, Issue 9, September 2026.
Eight chalcone‐sulfonamide hybrids (12a–h) are synthesized via Claisen–Schmidt condensation and evaluated for antibacterial, antioxidant, and anti‐inflammatory activity. The compounds show potent radical scavenging, strong protein‐denaturation inhibition surpassing diclofenac, and favorable docking against DHPS, myeloperoxidase, COX‐2, and ...
Mlis Belete, Endale Mulugeta, Daniel Rentsch, Muhdin Aliye, Kebede Shenkutie, Yadessa Melaku   +5 more
wiley   +1 more source

Modulation of Free Radical Formation by Pterin Derivatives

Pteridines, 2004
All classes of pterins, fully reduced tetrahydropterins, aromatic pterins and dihydropterins have been investigated upon their effects on radical mediated reactions.
Karl Oettl, Greilberger Joachim, Reibnegger Gilbert   +2 more
doaj   +1 more source

From o‐Phenylenediamine to Flavin Derivatives: A Potential Prebiotic Carbon Skeleton Expansion With Formaldehyde, Cyanide, and CO2

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A Strecker‐type reaction of aromatic ortho‐diamines with various aldehydes and cyanide assembles the bicyclic amidine core of flavin‐derived heterocycles under mild conditions. Subsequent oxidation, radical or photochemical cyanation, carboxylation with CO2, and CO2‐mediated cyclization build the three‐ring alloxazine scaffold. This sequence provides a
Christian Held, Rodrigo José da Silva Lima, Ji‐Woong Lee   +2 more
wiley   +1 more source

Developmental and Phenotypic Outcomes in Mild Phenylalanine Hydroxylase Deficiency

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1814-1820, August 2026.
ABSTRACT Benign hyperphenylalaninemia (bHPA) is defined as elevated phenylalanine (Phe) levels remaining ≤ 360 μmol/L (6 mg/dL) and not requiring medical intervention. Individuals with bHPA may demonstrate a rise in their Phe levels > 360 μmol/L, effectively developing a mild PKU phenotype requiring therapy to prevent neurocognitive complications. This
Aaron Williams, Kristian Divin, Lindsay C. Burrage, William J. Craigen, Fernando Scaglia, Claudia Soler‐Alfonso, V. Reid Sutton, Kevin E. Glinton, Ronit Marom   +8 more
wiley   +1 more source

Biomimetic Pieris rapae’s Nanostructure and Its Use as a Simple Sucrose Sensor

Micromachines, 2014
Biomimetics often provides efficient ways to create a product incorporating novel properties. Here we present the replication of the Pieris rapae butterfly optical structure. This butterfly has white wings with black spots.
David Bonzon, Rodrigo Martinez-Duarte, Philippe Renaud, Marc Madou   +3 more
doaj   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Pterin-Dependent Biocatalysts and Uses Thereof

, 2015
Provided herein are biocatalysts and systems thereof for pterin-dependent enzymes and pathways and methods of making and using the same. Provided herein in some embodiments are biocatalysts having a pterin source and a pterin-dependent enzymatic pathway ...

core  

Assignment of Pterin Deaminase Activity to an Enzyme of Unknown Function Guided by Homology Modeling and Docking [PDF]

, 2013
Of the over 22 million protein sequences in the nonredundant TrEMBL database, fewer than 1% have experimentally confirmed functions. Structure-based methods have been used to predict enzyme activities from experimentally determined structures; however ...
Fan, Hao, Lin, Henry, Shoichet, Brian K, Hillerich, Brandan, Almo, Steven C, Seidel, Ronald D, Hitchcock, Daniel S, Sali, Andrej, Raushel, Frank M   +8 more
core   +1 more source