Results 41 to 50 of about 4,377 (174)

Crystal structure of ricin toxin A chain complexed with a highly potent pterin-based small-molecular inhibitor

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Ricin toxin A chain (RTA), from Ricinus communis, is a deadly protein that inactivates ribosomes by degrading an adenine residue at position 4324 in 28S rRNA. Recently, we have demonstrated that pterin-7-carboxamides with peptide pendants were potent RTA
Masaru Goto, Natsumi Sakamoto, Shoko Higashi, Rena Kawata, Kazuki Nagatsu, Ryota Saito   +5 more
doaj   +1 more source

Room‐temperature crystal structure of a metal‐dependent W‐formate dehydrogenase by serial synchrotron crystallography

Acta Crystallographica Section D, Volume 82, Issue 9, Page 1072-1081, September 2026.
We report a room‐temperature serial synchrotron X‐ray crystallographic structural analysis of Nitratidesulfovibrio vulgaris formate dehydrogenase AB, an enzyme that reduces CO2 to formate.Metal‐dependent formate dehydrogenases (Fdhs) are a promising research target in efforts to mitigate climate change by developing active, efficient, selective and ...
Guilherme Vilela-Alves, Guilherme Martins, David von Stetten, Pedram Mehrabi, Inês A. C. Pereira, Maria João Romão, Arwen R. Pearson, Cristiano Mota   +7 more
wiley   +1 more source

From o‐Phenylenediamine to Flavin Derivatives: A Potential Prebiotic Carbon Skeleton Expansion With Formaldehyde, Cyanide, and CO2

Advanced Synthesis &Catalysis, Volume 368, Issue 16, 18 August 2026.
A Strecker‐type reaction of aromatic ortho‐diamines with various aldehydes and cyanide assembles the bicyclic amidine core of flavin‐derived heterocycles under mild conditions. Subsequent oxidation, radical or photochemical cyanation, carboxylation with CO2, and CO2‐mediated cyclization build the three‐ring alloxazine scaffold. This sequence provides a
Christian Held, Rodrigo José da Silva Lima, Ji‐Woong Lee   +2 more
wiley   +1 more source

Occurrence of Pterin Pigments in Hymenoptera [PDF]

Nature, 1950
IT has been found that pterins exist in tissues of animals belonging to nearly all groups; their occurrence as pigments, however, is restricted to insects and cold-blooded vertebrates1,2. Among Lepidoptera, they are always present in the wing-scales of the Pieridae and appear to be a biochemical characteristic of that natural family3,4.
openaire   +2 more sources

Developmental and Phenotypic Outcomes in Mild Phenylalanine Hydroxylase Deficiency

American Journal of Medical Genetics Part A, Volume 200, Issue 8, Page 1814-1820, August 2026.
ABSTRACT Benign hyperphenylalaninemia (bHPA) is defined as elevated phenylalanine (Phe) levels remaining ≤ 360 μmol/L (6 mg/dL) and not requiring medical intervention. Individuals with bHPA may demonstrate a rise in their Phe levels > 360 μmol/L, effectively developing a mild PKU phenotype requiring therapy to prevent neurocognitive complications. This
Aaron Williams, Kristian Divin, Lindsay C. Burrage, William J. Craigen, Fernando Scaglia, Claudia Soler‐Alfonso, V. Reid Sutton, Kevin E. Glinton, Ronit Marom   +8 more
wiley   +1 more source

Nucleotide Metabolism in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Nucleotide metabolism, including de novo synthesis, salvage pathways, and catabolism, when dysregulated contributes to cancer, immune disorders, metabolic and urological diseases, and radiation injury. Metabolites such as adenosine, cGAMP, NAD, and cAMP and enzymes like RNR are promising therapeutic targets and biomarkers.
Xiaoying Zhao, Yiyu Zeng, Yike Xu, Shu Rao, Mouna Khouchani, Hassna Soummane, Jingyi Li, Rui Liu   +7 more
wiley   +1 more source

Crystal structure of (2-amino-7-methyl-4-oxidopteridine-6-carboxylato-κ3O4,N5,O6)aqua(1,10-phenanthroline-κ2N,N′)copper(II) trihydrate

Acta Crystallographica Section E, 2014
In the title compound, [Cu(C8H5N5O3)(C12H8N2)(H2O)]·3H2O, the CuII cation is O,N,O′-chelated by the 2-amino-7-methyl-4-oxidopteridine-6-carboxylate anion and N,N′-chelated by the 1,10-phenanthroline (phen) ligand.
Siddhartha S. Baisya, Parag S. Roy
doaj   +1 more source

Chemical Profiling and In Vitro Assessment of Antioxidant and Antimicrobial Properties of Algerian Erica arborea L. Extracts, Strengthened by Molecular Modeling Analysis

ChemistryOpen, Volume 15, Issue 8, August 2026.
Erica arborea L. from Algeria was valorized via chemical profiling and bioactivity assessment. The EtOAc extract showed the highest levels of polyphenols, flavonoids, and flavonols. It exhibited strong antioxidant (ABTS•+, DPPH•, FRAP) and antibacterial activity (S. aureus, B. subtilis).
Amina Bramki, Ouided Benslama, Fatima Zohra Makhlouf, Anna Andolfi, Zineb Mokhbi, Selsabile Nedjaoum, Chawki Bensouici, Maria Michela Salvatore, Marco Masi   +8 more
wiley   +1 more source

Experimental and metabolic modeling evidence for a folate-cleaving side-activity of ketopantoate hydroxymethyltransferase (PanB)

Frontiers in Microbiology, 2016
Tetrahydrofolate (THF) and its one-carbon derivatives, collectively termed folates, are essential cofact¬ors, but are inherently unstable. While it is clear that chemical oxidation can cleave folates or damage their pterin precursors, very little is ...
Jennifer eThiaville, Océane eFrelin, Carolina eGarcía-Salinas, Ghulam eHasnain, Katherine eHarrison, Rocio eDíaz de la Garza, Nicole eHorenstein, Christopher eHenry, Andrew D Hanson, Valérie ede Crécy-Lagard   +9 more
doaj   +1 more source

Testing for the Presence of Photobionts in Eucypris virens (Crustacea: Ostracoda) Green Valves

Freshwater Biology, Volume 71, Issue 8, August 2026.
ABSTRACT Crustaceans exhibit a wide range of organic pigments with different colorations and functions. However, little is known about the origin and function of the characteristic green pigmentation that podocopid ostracods, and in particular Eucypris virens, exhibit in their valves.
Julio Cruz‐Vila, Alexandre Mestre, Antonio Picazo, Olivier Schmit, Ian Boomer, Antonio Camacho, Ferran Palero, Francesc Mesquita‐Joanes   +7 more
wiley   +1 more source