Results 121 to 130 of about 2,933 (162)

Bone anabolic therapy in breast cancer: is there a role for parathyroid hormone or parathyroid hormone-related protein? [PDF]

JBMR Plus
Taipaleenmäki H, Drake MT.
europepmc   +1 more source

Structural insights into GPCR signaling activated by peptide ligands: from molecular mechanism to therapeutic application. [PDF]

Exp Mol Med
Kim J, Kim J, Choi C, Bae J, Choi HJ.
europepmc   +1 more source

The function of GPCRs in different bone cells. [PDF]

Int J Biol Sci
Zhang Y, Wang NN, Qiu ZH, Wang JH, An WN, Shi LD, Chen F, Zhang DJ, Wang SY, Yang TL, Hu SY, Guo Y.   +11 more
europepmc   +1 more source

Early-life exposure to polypropylene nanoplastics induces neurodevelopmental toxicity in mice and human iPSC-derived cerebral organoids. [PDF]

J Nanobiotechnology
Huang F, You H, Tang X, Su Y, Peng H, Li H, Wei Z, Hua J.   +7 more
europepmc   +1 more source

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Salt inducible kinases and PTH1R action

2022
Parathyroid hormone is a central regulator of calcium homeostasis. PTH protects the organism from hypocalcemia through its actions in bone and kidney. Recent physiologic studies have revealed key target genes for PTH receptor (PTH1R) signaling in these target organs.
Sung-Hee, Yoon, Cheng-Chia, Tang, Marc N, Wein   +2 more
openaire   +2 more sources

Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice

Endocrinology, 2022
Abstract Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogues for their pharmacologic activities and potential therapeutic utility toward diseases of bone and mineral ion metabolism.
Henry Kronenberg, Daniel Brooks, Thomas Gardella   +2 more
exaly   +3 more sources

Modulation of PTH1R signaling by an extracellular binding antibody

2022
Parathyroid hormone receptor 1 (PTH1R) is a class B G-protein coupled receptor with key roles in bone development. The receptor signals through both the Gs and Gq G-proteins as well as through β-arrestin in a G-protein independent manner. Current treatments for bone disorders, such as osteoporosis, target the PTH1R but are suboptimal in their efficacy.
Kaushik, Sarkar, Lisa, Joedicke, Marta, Westwood, Rebecca, Burnley, Michael, Wright, David, McMillan, Bernadette, Byrne   +6 more
openaire   +2 more sources