Results 131 to 140 of about 2,933 (162)

PTH1R Suppressed Apoptosis of Mesenchymal Progenitors in Mandibular Growth

International Journal of Molecular Sciences
Genetic abnormalities of the parathyroid hormone 1 receptor (PTH1R) lead to profound craniomaxillofacial bone and dentition defects on account of inappropriate tissue metabolism and cellular differentiation. The coordinated activity of differentiation and viability in bone cells is indispensable for bone metabolism.
Yi Fan, Xi Wei, Xuedong Zhou
exaly   +3 more sources

Physiological and Pharmacological Roles of PTH and PTHrP in Bone Using Their Shared Receptor, PTH1R [PDF]

Endocrine Reviews, 2021
Abstract Parathyroid hormone (PTH) and the paracrine factor, PTH-related protein (PTHrP), have preserved in evolution sufficient identities in their amino-terminal domains to share equivalent actions upon a common G protein-coupled receptor, PTH1R, that predominantly uses the cyclic adenosine monophosphate-protein kinase A signaling ...
T John Martin, Ego Seeman, Natalie Sims   +2 more
exaly   +5 more sources

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Expression of PTH1R constructs in LLC-PK1 cells: Protein nuclear targeting is mediated by the PTH1R NLS

Bone, 2007
This study demonstrates that the PTH1R NLS can target a fusion protein to the nucleus, and that this is blocked by sequences downstream of the NLS. GFP fused to the NLS showed a significant increase in nuclear targeting compared to GFP alone or GFP fused to a peptide of the same length.
Eric K, Patterson, Patricia H, Watson, Anthony B, Hodsman, Geoffrey N, Hendy, Lucie, Canaff, F Richard, Bringhurst, Clare H, Poschwatta, Laurence J, Fraher   +7 more
openaire   +2 more sources

Primary cilia and PTH1R interplay in the regulation of osteogenic actions

2022
Primary cilia are subcellular structures specialized in sensing different stimuli in a diversity of cell types. In bone, the primary cilium is involved in mechanical sensing and transduction of signals that regulate the behavior of mesenchymal osteoprogenitors, osteoblasts and osteocytes.
Juan A, Ardura, Eduardo, Martín-Guerrero, Sara, Heredero-Jiménez, Arancha R, Gortazar   +3 more
openaire   +2 more sources

Pth1r Signal in Gli1+ Cells Maintains Postnatal Cranial Base Synchondrosis

Journal of Dental Research, 2023
Cranial base synchondroses are the endochondral ossification centers for cranial base growth and thus indispensable for proper skull, brain, and midfacial development. The synchondroses are composed of mirror-image growth plates that are continuously maintained from the embryonic to postnatal stage through chondrocyte ...
Yoshihiro Kitaoka
exaly   +3 more sources

Molcular Dynamics Trajectories for PTH1R-Arrestin Complex Repository_6U1B

2023
Molecular Dynamics Data for 10.1038/s41467-023-36797-2 for publication at Aydin Y, Böttke T, Lam JH, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I. Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nat Commun. 2023 Mar 1;14(1):1151. doi: 10.1038/s41467-023-
Jordy Homing Lam, Yasmin Aydin, Thore Böttke   +2 more
openaire   +3 more sources

Functional Analysis of PTH1R Variants Found in Primary Failure of Eruption

Journal of Dental Research, 2020
Although many variants of the parathyroid hormone 1 receptor (PTH1R) gene are known to be associated with primary failure of eruption (PFE), the mechanisms underlying the link remains poorly understood. We here performed functional analyses of PTH1R variants reported in PFE patients—namely, 356C>T (P119L), 395C>T (P132L ...
E, Izumida, T, Suzawa, Y, Miyamoto, A, Yamada, M, Otsu, T, Saito, T, Yamaguchi, K, Nishimura, M, Ohtaka, M, Nakanishi, K, Yoshimura, K, Sasa, R, Takimoto, R, Uyama, T, Shirota, K, Maki, R, Kamijo   +16 more
openaire   +2 more sources

Decreased expression of PTH1R is a poor prognosis in hepatocellular carcinoma

Cancer Biomarkers, 2018
BACKGROUND AND AIM: Hypercalcemia is a potentially fatal and not rare complication of hepatocellular carcinoma (HCC), and its underlying mechanism remains unclear. Parathyroid hormone (PTH) is the most important regulator of the concentrations of calcium and phosphate in blood; parathyroid hormone-related protein (PTHrP) was the most frequent cause of ...
Hui-Ju, Wang, Liang, Wang, Shu-Shu, Song, Xiang-Lei, He, Hong-Ying, Pan, Zhi-Ming, Hu, Xiao-Zhou, Mou   +6 more
openaire   +2 more sources

Role of PTH1R Signaling in Prx1 ⁺ Mesenchymal Progenitors during Eruption

Journal of Dental Research, 2020
Tooth eruption is a complex process requiring precise interaction between teeth and adjacent tissues. Molecular analysis demonstrates that bone remodeling plays an essential role during eruption, suggesting that a parathyroid hormone 1 receptor (PTH1R) gene mutation is associated with disturbances in bone remodeling and results in ...
C, Cui, R, Bi, W, Liu, S, Guan, P, Li, D, Song, R, Xu, L, Zheng, Q, Yuan, X, Zhou, Y, Fan   +10 more
openaire   +2 more sources

Characterization of a PTH1R missense mutation responsible for Jansen type metaphyseal chondrodysplasia

Odontology / the Society of the Nippon Dental University, 2016
Parathyroid hormone and parathyroid hormone-related peptide (PTHrP), and its receptor (PTH1R) play an important role in differentiation of bone and cartilage in the developing stages. Constitutive dimers of PTH1R are believed to be dissociated by ligand binding, and monomeric PTH1R is capable of activating G protein.
Yutaka Shimomura, Amizuka Norio, Shimomura Yutaka   +2 more
exaly   +3 more sources