Results 141 to 150 of about 2,933 (162)
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Ischemic injury activates PTHrP and PTH1R expression in human ventricular cardiomyocytes
Basic Research in Cardiology, 2009The PTHrP/PTH1R signalling system induces calciotropic and myorelaxant effects on the vascular system and plays critical roles in the development of the cardiovascular system. In animal models, PTHrP exerts important effects on heart rate and contractility, particularly under ischemic conditions, while, in human hearts, the expression of PTHrP by ...
Ornella Leone +2 more
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Expanding the spectrum of PTH1R mutations in patients with primary failure of tooth eruption
Clinical Oral Investigations, 2013Primary failure of tooth eruption (PFE) is a rare autosomal-dominant disease characterized by severe lateral open bite as a consequence of incomplete eruption of posterior teeth. Heterozygous mutations in the parathyroid hormone 1 receptor (PTH1R) gene have been shown to cause PFE likely due to protein haploinsufficiency.
Roth, Helmut +9 more
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Pth1r in Neural Crest Cells Regulates Nasal Cartilage Differentiation
Journal of Dental ResearchNeural crest cells (NCC) arise from the dorsal margin of the neural plate border and comprise a unique cell population that migrates to and creates the craniofacial region. Although factors including Shh, Fgf8, and bone morphogenetic proteins have been shown to regulate these biological events, the role of parathyroid hormone 1 ...
K. Amano +6 more
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Molcular Dynamics Trajectories for PTH1R-Arrestin Complex Repository_6U1B No Water
2023Molecular Dynamics Data for 10.1038/s41467-023-36797-2 for publication at Aydin Y, Böttke T, Lam JH, Ernicke S, Fortmann A, Tretbar M, Zarzycka B, Gurevich VV, Katritch V, Coin I. Structural details of a Class B GPCR-arrestin complex revealed by genetically encoded crosslinkers in living cells. Nat Commun. 2023 Mar 1;14(1):1151. doi: 10.1038/s41467-023-
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Parathyroid hormone–PTH1R signaling in cardiovascular disease and homeostasis
Trends in Endocrinology & MetabolismPrimary hyperparathyroidism (pHPT) afflicts our aging population with an incidence approaching 50 per 100 000 patient-years at a female:male ratio of ~3:1. Decisions surrounding surgical management are currently driven by age, hypercalcemia severity, presence of osteoporosis, renal insufficiency, or hypercalciuria with or without nephrolithiasis ...
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Activation of PTH1R alleviates epididymitis and orchitis through Gq and β-arrestin-1 pathways
Proceedings of the National Academy of Sciences of the United States of America, 2021Ming-Wei Wang, Zhao Yang, Wenming Xu
exaly
significance of PTH1R variants of an Italian sample with primary afilure of eruption
2020AIM: Primary failure of eruption (PFE) is characterized by non-syndromic eruption failure of not ankylosed teeth, which fail in their eruptive process partially or completely, without any systemic disease or mechanical interference identifiable. This condition is different from the mechanical eruption failure (MFE) due to a mechanical obstacle. Primary
Grippaudo C. +6 more
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