Results 101 to 110 of about 92,645 (204)

Effects of Different pH Levels on the Structural and Functional Properties of Proteins of Phaeodactylum tricornutum

open access: yesMolecules
Phaeodactylum tricornutum is identified by its capacity for rapid growth, reproduction, and in vitro cultivation, as well as the presence of a range of high-value active compounds, including proteins, with potential food applications.
Yanli Wang   +4 more
doaj   +1 more source

Patient‐reported outcomes, postoperative pain and pain relief after day‐case surgery (POPPY): chronic post‐surgical pain prevalence and associations*

open access: yesAnaesthesia, Volume 81, Issue 4, Page 489-499, April 2026.
Summary Introduction Day‐case surgical activity is increasing in the UK yet there is a lack of data on the prevalence of chronic post‐surgical pain in this population. This study uses data from the POPPY study to estimate the prevalence of chronic post‐surgical pain after day‐case surgery, its relationship with quality of life and also explores ...
Adam B. Brayne   +2177 more
wiley   +1 more source

UITOTO: a software for generating molecular diagnoses for species descriptions

open access: yesCladistics, Volume 42, Issue 2, Page 193-205, April 2026.
Abstract Millions of species remain undescribed, and each eventually will require a species description with a diagnosis. Yet, we lack software that can derive state‐specific and contrastive molecular diagnoses and allows the user to validate them based on all available sequences for the taxon under study. Here we introduce UITOTO, which addresses this
Ambrosio Torres   +3 more
wiley   +1 more source

Comparison of Blood Cell Count Results Between MgSO4 and K2EDTA. Stability and Accuracy of Platelet Counting With MgSO4

open access: yesInternational Journal of Laboratory Hematology, Volume 48, Issue 2, Page 336-344, April 2026.
ABSTRACT Introduction We investigated the stability and accuracy of platelets with MgSO4 and compared the results of blood counts between MgSO4 and K2EDTA. Methods Platelet stability as a function of time was assessed on the XN Sysmex analyzer by comparing the percentage deviation to the desirable bias of the EFLM.
Michel Soulard   +4 more
wiley   +1 more source

Ungesättigte Phosphor‐Elektrophile zur Untersuchung von Protein‐Tyrosin‐Phosphatasen

open access: yesAngewandte Chemie, Volume 138, Issue 11, 9 March 2026.
Negativ geladene Aryl‐Ethynyl‐Phosphonamid‐ und Phosphonsäuren werden als reaktionsarme Elektrophile für peptidbasierte Aktivitätssonden eingeführt, die eine selektive, zielspezifische Profilierung von Protein‐Tyrosin‐Phosphatasen ermöglichen. Die Sonden zeigen keine Off‐Target‐Cystein‐Reaktivität und binden in der globalen Proteomanalyse nur an die ...
Eleftheria Poulou   +4 more
wiley   +1 more source

Structure‐Guided Engineering of a Promiscuous O‐Methyltransferase for a SAM Regeneration Biocatalysis Platform of Methylated Pharmaceuticals

open access: yesAdvanced Science, Volume 13, Issue 13, 3 March 2026.
A substrate promiscuous and regioselective O‐methyltransferase, SmOMT, is functionally and structurally characterized. A double mutant, SmOMTE152A/I306A, exhibited enhanced catalytic activity. By coupling this mutant with a mutant halide methyltransferase, AtHMTV140T, for SAM regeneration, a superior artificial fusion enzyme, AtHMTV140T‐L95‐SmOMTE152A ...
Xiran Xiong   +11 more
wiley   +1 more source

The Rise of Organic Electrochemical Transistors for Brain‐Inspired Neuromorphic Computing

open access: yesAdvanced Electronic Materials, Volume 12, Issue 5, 9 March 2026.
This review provides a comprehensive overview of organic electrochemical transistors (OECTs) for brain‐inspired computing. From fundamental device physics and material engineering to system‐level integration, it highlights OECTs' unique mixed ionic‐electronic conduction capabilities.
Heejin Kim, Hyunhak Jeong, Gunuk Wang
wiley   +1 more source

An overview of the postcranial osteology of caecilians (Gymnophiona, Lissamphibia)

open access: yesThe Anatomical Record, Volume 309, Issue 3, Page 674-699, March 2026.
Abstract Caecilians comprise a relatively small (~220 species) group (Gymnophiona) of snake‐like or worm‐like, mostly tropical amphibians. Most adult caecilians are fossorial, although some species may live in aquatic or semi‐aquatic environments, either as larvae or adults.
Rodolfo Otávio Santos   +2 more
wiley   +1 more source

Breaking Barriers: Characterization of the Intradermal Lipopolysaccharide Challenge as an In Vivo Model for Controlled Induction of Vascular Leakage in Healthy Volunteers

open access: yesClinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 678-687, March 2026.
Vascular leakage and its associated phenomena vasodilation and endothelial activation are pathophysiological features of various diseases. Multiple drug candidates targeting these phenomena are in development, necessitating translational models to demonstrate proof‐of‐pharmacology and proof‐of‐mechanism in early‐phase clinical trials.
Marella Cornelia Elizabeth van Ruissen   +10 more
wiley   +1 more source

The JAK/STAT Pathway in Cancer: From Molecular Mechanisms to Clinical Applications

open access: yesMedComm – Oncology, Volume 5, Issue 1, March 2026.
Dysregulated JAK/STAT signaling and related genetic mutations are strongly associated with cancer progression, including promoting tumor proliferation, suppressing apoptosis, inducing immune suppression, participating in drug resistance. Based on the function of the JAK/STAT pathway in disease pathogenesis, numerous agents targeting the JAK/STAT ...
Yixing Liao   +10 more
wiley   +1 more source

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