Results 41 to 50 of about 350,979 (277)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Mitochondria-targeted derivative of pterostilbene, a dietary phytoestrogen, exhibits superior cancer cell cytotoxicity via mitochondrial superoxide mediated induction of autophagy

Advances in Redox Research, 2023
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene;PTS), a dimethyl ether analogue of resveratrol, has been shown to possess anti-bacterial, anti-cancer, anti-inflammatory and antioxidant properties.
Mahin K. Ibrahim, Shivani R. Nandha, Ashwani S. Patil, Sadhana Sathaye, Mariam S. Degani, Binita Kumar, Rahul Checker, Deepak Sharma, Santosh K. Sandur   +8 more
doaj   +1 more source

Magnetization reversal in [Ni/Pt]6/Pt(x)/[Co/Pt]6 multilayers

Journal of Magnetism and Magnetic Materials, 2011
Abstract The magnetization reversal is studied in magnetron sputtered artificial superstructures of the form [Ni/Pt] 6 /Pt( x )/[Co/Pt] 6 with perpendicular anisotropy, in which the [Co/Pt] 6 stacks have higher coercivity than the [Ni/Pt] 6 . For x ≥2 nm the two stacks reverse separately and exhibit characteristic stepped loops with a “plateau” in
Siadou, N., Androutsopoulos, M., Panagiotopoulos, I., Stoleriu, L., Stancu, A., Bakas, T., Alexandrakis, V.   +6 more
openaire   +2 more sources

Thermodynamics, phase transitions and Ruppeiner geometry for Einstein-dilaton Lifshitz black holes in the presence of Maxwell and Born-Infeld electrodynamics

, 2016
In this paper, we first obtain the ($n+1$)-dimensional dilaton-Lifshitz black hole (BH) solutions in the presence of Born-Infeld (BI) electrodynamics.
Dehyadegari, A., Mehdizadeh, M. R., Sheykhi, A., Wang, B., Zangeneh, M. Kord   +4 more
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumour cells

Journal of Nanobiotechnology
MicroRNAs (miRNAs) have been recognised as potential biomarkers due to their specific expression patterns in different biological tissues and their changes in expression under pathological conditions. MicroRNA-122 (miR-122) is a vertebrate-specific miRNA
Agustín Robles-Remacho, Ismael Martos-Jamai, Mavys Tabraue-Chávez, Araceli Aguilar-González, Jose A. Laz-Ruiz, M. Victoria Cano-Cortés, F. Javier López-Delgado, Juan J. Guardia-Monteagudo, Salvatore Pernagallo, Juan J. Diaz-Mochon, Rosario M. Sanchez-Martin   +10 more
doaj   +1 more source

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Molecular Therapy: Nucleic Acids, 2013
Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC).
Kenneth L Clark, Stephen A Hughes, Pallav Bulsara, Jill Coates, Kitty Moores, Joel Parry, Michael Carr, Ruth J Mayer, Paul Wilson, Chris Gruenloh, Daren Levin, Jill Darton, Wolf-Michael Weber, Katja Sobczak, Deborah R Gill, Stephen C Hyde, Lee A Davies, Ian A Pringle, Stephanie G Sumner-Jones, Vasant Jadhav, Sharon Jamison, Walter R Strapps, Victoria Pickering, Mark R Edbrooke   +23 more
doaj   +1 more source

Key steps and methods in the experimental design and data analysis of highly multi-parametric flow and mass cytometry

Computational and Structural Biotechnology Journal, 2020
High-dimensional, single-cell cell technologies revolutionized the way to study biological systems, and polychromatic flow cytometry (FC) and mass cytometry (MC) are two of the drivers of this revolution.
Paulina Rybakowska, Marta E. Alarcón-Riquelme, Concepción Marañón   +2 more
doaj   +1 more source

Political ties and venture capital : evidence from China : a thesis presented in fulfilment of the requirement for the degree of Doctor of Philosophy in Finance at Massey University, Palmerston North, New Zealand [PDF]

, 2016
This thesis investigates whether venture capital firms (VCs) benefit from political ties (PTs), and whether VCs add value to China’s public equity market by constraining earnings management (EM) and improving corporate governance of their backed firms ...
Wang, Qing
core  

Influence of laser spot size at diffuser plane on the longitudinal spatial coherence function of optical coherence microscopy system

, 2019
Coherence properties and wavelength of light sources are indispensable for optical coherence microscopy/tomography as they greatly influence the signal to noise ratio, axial resolution, and penetration depth of the system.
Ahmad, Azeem, Butola, Ankit, Dubey, Vishesh, Joshi, Rakesh, Mehta, Dalip Singh, Usmani, Kashif   +5 more
core   +1 more source