Results 41 to 50 of about 349,458 (278)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Key steps and methods in the experimental design and data analysis of highly multi-parametric flow and mass cytometry

Computational and Structural Biotechnology Journal, 2020
High-dimensional, single-cell cell technologies revolutionized the way to study biological systems, and polychromatic flow cytometry (FC) and mass cytometry (MC) are two of the drivers of this revolution.
Paulina Rybakowska, Marta E. Alarcón-Riquelme, Concepción Marañón   +2 more
doaj   +1 more source

Magnetization reversal in [Ni/Pt]6/Pt(x)/[Co/Pt]6 multilayers

Journal of Magnetism and Magnetic Materials, 2011
Abstract The magnetization reversal is studied in magnetron sputtered artificial superstructures of the form [Ni/Pt] 6 /Pt( x )/[Co/Pt] 6 with perpendicular anisotropy, in which the [Co/Pt] 6 stacks have higher coercivity than the [Ni/Pt] 6 . For x ≥2 nm the two stacks reverse separately and exhibit characteristic stepped loops with a “plateau” in
Siadou, N., Androutsopoulos, M., Panagiotopoulos, I., Stoleriu, L., Stancu, A., Bakas, T., Alexandrakis, V.   +6 more
openaire   +2 more sources

NCI-MATCH Arms N & P: Phase II study of PI3K beta inhibitor GSK2636771 in patients (pts) with cancers (ca) with PTEN mutation/deletion (mut/del) or PTEN protein loss [PDF]

, 2018
Background: The NCI-MATCH trial is the largest national study (1173 sites) for ptswith relapsed/ refractory solid tumors, lymphomas and myeloma, which assigns tar-geted therapies based on individual tumor molecular alterations detected using theadapted ...
Arteaga, C., Chen, A. P., Conley, B. A., Doyle, L. A., Flaherty, K. T., Hamilton, S. R., Harris, L. N., Janku, F., Jegede, O., Konstantinopoulos, P., Li, S., McShane, L. M., Meric-Bernstam, F., Mitchell, E. P, O\u27Dwyer, P. J., Patton, D., Puhalla, S. L., Rubinstein, L. V., Williams, P. M., Zwiebel, J. A.   +19 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumour cells

Journal of Nanobiotechnology
MicroRNAs (miRNAs) have been recognised as potential biomarkers due to their specific expression patterns in different biological tissues and their changes in expression under pathological conditions. MicroRNA-122 (miR-122) is a vertebrate-specific miRNA
Agustín Robles-Remacho, Ismael Martos-Jamai, Mavys Tabraue-Chávez, Araceli Aguilar-González, Jose A. Laz-Ruiz, M. Victoria Cano-Cortés, F. Javier López-Delgado, Juan J. Guardia-Monteagudo, Salvatore Pernagallo, Juan J. Diaz-Mochon, Rosario M. Sanchez-Martin   +10 more
doaj   +1 more source

Mitochondria-targeted derivative of pterostilbene, a dietary phytoestrogen, exhibits superior cancer cell cytotoxicity via mitochondrial superoxide mediated induction of autophagy

Advances in Redox Research, 2023
Pterostilbene (trans-3,5-dimethoxy-4-hydroxystilbene;PTS), a dimethyl ether analogue of resveratrol, has been shown to possess anti-bacterial, anti-cancer, anti-inflammatory and antioxidant properties.
Mahin K. Ibrahim, Shivani R. Nandha, Ashwani S. Patil, Sadhana Sathaye, Mariam S. Degani, Binita Kumar, Rahul Checker, Deepak Sharma, Santosh K. Sandur   +8 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Molecular Therapy: Nucleic Acids, 2013
Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC).
Kenneth L Clark, Stephen A Hughes, Pallav Bulsara, Jill Coates, Kitty Moores, Joel Parry, Michael Carr, Ruth J Mayer, Paul Wilson, Chris Gruenloh, Daren Levin, Jill Darton, Wolf-Michael Weber, Katja Sobczak, Deborah R Gill, Stephen C Hyde, Lee A Davies, Ian A Pringle, Stephanie G Sumner-Jones, Vasant Jadhav, Sharon Jamison, Walter R Strapps, Victoria Pickering, Mark R Edbrooke   +23 more
doaj   +1 more source

Efficacy and safety of universal (TCRKO) ARI-0001 CAR-T cells for the treatment of B-cell lymphoma

Frontiers in Immunology, 2022
Autologous T cells expressing the Chimeric Antigen Receptor (CAR) have been approved as advanced therapy medicinal products (ATMPs) against several hematological malignancies.
Noelia Maldonado-Pérez, María Tristán-Manzano, María Tristán-Manzano, Pedro Justicia-Lirio, Pedro Justicia-Lirio, Elena Martínez-Planes, Pilar Muñoz, Pilar Muñoz, Kristina Pavlovic, Kristina Pavlovic, Marina Cortijo-Gutiérrez, Carlos Blanco-Benítez, Carlos Blanco-Benítez, María Castella, Manel Juan, Mathias Wenes, Pedro Romero, Francisco J. Molina-Estévez, Concepción Marañón, Concha Herrera, Karim Benabdellah, Francisco Martin, Francisco Martin   +22 more
doaj   +1 more source