Results 61 to 70 of about 352,027 (304)

Potential of the Other Genetic Information Coded by the Viral RNA Genomes as Antiviral Target

Pharmaceuticals, 2019
In addition to the protein coding information, viral RNA genomes code functional information in structurally conserved units termed functional RNA domains.
Alfredo Berzal-Herranz, Cristina Romero-López, Beatriz Berzal-Herranz, Sara Ramos-Lorente   +3 more
doaj   +1 more source

Nucleobase Stacking Sustained by Pt−Pt Interactions

ChemistryEurope
AbstractThis article reports the use of metal–metal interactions as a way to induce nucleobase stacking in a dinucleotide chain. We synthetized and study a series of C,N‐cyclometallated platinum(II) binuclear complexes derived from 6‐phenylpurine dinucleotide 1 as proligand, and β‐diketonates, 2,2'‐bipyridines and 1,10‐phenanthroline as ancillary ...
Carmen Lorenzo‐Aparicio, Pablo García‐Álvarez, Javier A. Cabeza, Mar Gómez‐Gallego, Miguel A. Sierra   +4 more
openaire   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Influence of laser spot size at diffuser plane on the longitudinal spatial coherence function of optical coherence microscopy system

, 2019
Coherence properties and wavelength of light sources are indispensable for optical coherence microscopy/tomography as they greatly influence the signal to noise ratio, axial resolution, and penetration depth of the system.
Ahmad, Azeem, Butola, Ankit, Dubey, Vishesh, Joshi, Rakesh, Mehta, Dalip Singh, Usmani, Kashif   +5 more
core   +1 more source

A High‐Sensitivity Circulating Nucleic Acid Sequencing Assay for Assessing Treatment Response to Alectinib in a Pediatric Patient With ALK‐Rearranged Non–Small Cell Lung Cancer

Pediatric Blood &Cancer, EarlyView.
Alberto D. Guerra, Nicholas F. Evageliou, Vandana Batra, Kristen L. Dalton, Stephanie Ortel, Usman Ashraf, Tricia R. Bhatti, Lisa J. States, Lea F. Surrey, Theodore W. Laetsch   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Epigenetic changes produced in women victims of intimate partner violence: A systematic review

Women's Health
Background: Intimate partner violence (IPV) is a prevalent form of violence against women that encompasses physical, sexual, and emotional abuse, as well as controlling behaviors by intimate partners, and predisposes the victims to multiple diseases ...
Coral González-Martínez, Christian Haarkötter, Elena Carnero-Montoro, Jose A Lorente, Miguel Lorente   +4 more
doaj   +1 more source

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

Molecular Therapy: Nucleic Acids, 2018
Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this study,
Sabina Sánchez-Hernández, Alejandra Gutierrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierrez, María Tristán-Manzano, Sandra Rodriguez-Perales, Laura Sanchez, Jose Luis Garcia-Perez, Jesus Chato-Astrain, Ricardo Fernandez-Valades, Ana Belén Carrillo-Galvez, Per Anderson, Rosa Montes, Pedro J. Real, Francisco Martin, Karim Benabdellah   +15 more
doaj   +1 more source

SPDL Model Checking via Property-Driven State Space Generation [PDF]

, 2007
In this report we describe how both, memory and time requirements for stochastic model checking of SPDL (stochastic propositional dynamic logic) formulae can significantly be reduced. SPDL is the stochastic extension of the multi-modal program logic PDL.\
Haverkort, Boudewijn R., Kuntz, Matthias
core   +1 more source

Power-constrained block-test list scheduling [PDF]

, 2000
A list scheduling approach is proposed in this paper to overcome the problem of unequal-length block-test scheduling under power dissipation constraints. An extended tree growing technique is also used in combination with the list scheduling algorithm in
Muresan, Valentin, Muresan, Valentina, Vladutiu, M., Wang, Xiaojun   +3 more
core   +1 more source