Results 71 to 80 of about 352,027 (304)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Political ties and venture capital : evidence from China : a thesis presented in fulfilment of the requirement for the degree of Doctor of Philosophy in Finance at Massey University, Palmerston North, New Zealand [PDF]

, 2016
This thesis investigates whether venture capital firms (VCs) benefit from political ties (PTs), and whether VCs add value to China’s public equity market by constraining earnings management (EM) and improving corporate governance of their backed firms ...
Wang, Qing
core  

Never events in UK general practice: a survey of the views of general practitioners on their frequency and acceptability as a safety improvement approach [PDF]

, 2019
Background: Never events (NEs) are serious preventable patient safety incidents and are a component of formal quality and safety improvement (Q&SI) policies in the United Kingdom and elsewhere.
Alam, Rahul, Bowie, Paul, Campbell, Stephen, Cheraghi-Sohi, Sudeh, de Wet, Carl, Esmail, Aneez, Stocks, Susan J.   +6 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Convex Optimization Based Bit Allocation for Light Field Compression under Weighting and Consistency Constraints

, 2018
Compared with conventional image and video, light field images introduce the weight channel, as well as the visual consistency of rendered view, information that has to be taken into account when compressing the pseudo-temporal-sequence (PTS) created ...
Guo, Bichuan, Han, Yuxing, Wen, Jiangtao
core   +1 more source

Corporal diagnostic work and diagnostic spaces: Clinicians' use of space and bodies during diagnosis [PDF]

, 2015
© 2015 The Authors. Sociology of Health & Illness © 2015 Foundation for the Sociology of Health & Illness/John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution ...
Buscher M., Callon M., Gardner J., Goodwin D, Henke C. R., Jutel A. G., Keating P., Knorr‐Cetina K., Latour B., Latour B., Latour B., Latour B., Law J., Lynch M., Reeves A. G., Ryder D., Shusterman R.   +16 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Development of bismuth-based solutions for well plugging and abandonment: A review

Petroleum Research
Plugging and abandonment (P&A) is a crucial step of the well life cycle. Regardless of how long one stretches the productive life of a well, P&A operations will have to be carried out eventually.
Lewaa Hmadeh, Marcelo Anunciação Jaculli, Behzad Elahifar, Sigbjørn Sangesland   +3 more
doaj   +1 more source

Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy

Breast Cancer Research, 2019
Background Breast cancer patients under neoadjuvant chemotherapy includes a heterogeneous group of patients who eventually develop distal disease, not detectable by current methods.
Alba Rodríguez-Martínez, Diego de Miguel-Pérez, Francisco Gabriel Ortega, José Luis García-Puche, Inmaculada Robles-Fernández, José Exposito, Jordi Martorell-Marugan, Pedro Carmona-Sáez, María del Carmen Garrido-Navas, Christian Rolfo, Hugh Ilyine, José Antonio Lorente, Marta Legueren, María José Serrano   +13 more
doaj   +1 more source

Various ordered states in a 2D interacting electron system close to an electronic topological transition

, 1999
We consider a 2D electron system on a square lattice with hopping beyond nearest neighbors. The existence of the quantum critical point associated with an electronic topological transition in the noninteracting system results in density wave (DW) and ...
Bouis, F., Kiselev, M. N., Onufrieva, F., Pfeuty, P.   +3 more
core   +1 more source