Results 71 to 80 of about 103,920 (315)

Epigenetic changes produced in women victims of intimate partner violence: A systematic review

Women's Health
Background: Intimate partner violence (IPV) is a prevalent form of violence against women that encompasses physical, sexual, and emotional abuse, as well as controlling behaviors by intimate partners, and predisposes the victims to multiple diseases ...
Coral González-Martínez, Christian Haarkötter, Elena Carnero-Montoro, Jose A Lorente, Miguel Lorente   +4 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The effect of gender, age, and body mass index on the medial and lateral posterior tibial slopes: a magnetic resonance imaging study

Knee Surgery & Related Research, 2021
Background The posterior tibial slope (PTS) is crucial in knee joint stability and in maintaining the natural movement of the knee. An increase in the PTS is associated with various knee pathologic conditions, such as anterior cruciate ligament (ACL ...
Wazzan S. Aljuhani, Salman S. Qasim, Abdullah Alrasheed, Jumanah Altwalah, Mohammed J. Alsalman   +4 more
doaj   +1 more source

Nucleobase Stacking Sustained by Pt−Pt Interactions

ChemistryEurope
AbstractThis article reports the use of metal–metal interactions as a way to induce nucleobase stacking in a dinucleotide chain. We synthetized and study a series of C,N‐cyclometallated platinum(II) binuclear complexes derived from 6‐phenylpurine dinucleotide 1 as proligand, and β‐diketonates, 2,2'‐bipyridines and 1,10‐phenanthroline as ancillary ...
Carmen Lorenzo‐Aparicio, Pablo García‐Álvarez, Javier A. Cabeza, Mar Gómez‐Gallego, Miguel A. Sierra   +4 more
openaire   +3 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

¿Hacia una aceleración de la automatización y el “fin del trabajo”?

Cuadernos de Economía Crítica, 2022
A partir del libro Automatización y el futuro del trabajo, de Aaron Benanav, y la polémica entre este autor y Kim Moody, abordamos en este artículo la discusión de cómo vienen impactando los desarrollos tecnológicos como la inteligencia artificial y la ...
Esteban Mercatante
doaj  

The IS2 Element Improves Transcription Efficiency of Integration-Deficient Lentiviral Vector Episomes

Molecular Therapy: Nucleic Acids, 2018
Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this study,
Sabina Sánchez-Hernández, Alejandra Gutierrez-Guerrero, Rocío Martín-Guerra, Marina Cortijo-Gutierrez, María Tristán-Manzano, Sandra Rodriguez-Perales, Laura Sanchez, Jose Luis Garcia-Perez, Jesus Chato-Astrain, Ricardo Fernandez-Valades, Ana Belén Carrillo-Galvez, Per Anderson, Rosa Montes, Pedro J. Real, Francisco Martin, Karim Benabdellah   +15 more
doaj   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Reduced complexity PTS and new phase sequences for SLM to reduce PAP of an OFDM signal

, 2000
This paper presents a simplified version of partial transmit sequences (PTS) and a new scheme for selected mapping sequences to reduce peak-to-average power ratio (PAP) of an OFDM signal.
Wu, H., Jayalath, Dhammika, Tellambura, Chintha   +2 more
core   +1 more source

Development of bismuth-based solutions for well plugging and abandonment: A review

Petroleum Research
Plugging and abandonment (P&A) is a crucial step of the well life cycle. Regardless of how long one stretches the productive life of a well, P&A operations will have to be carried out eventually.
Lewaa Hmadeh, Marcelo Anunciação Jaculli, Behzad Elahifar, Sigbjørn Sangesland   +3 more
doaj   +1 more source