Results 51 to 60 of about 103,920 (315)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

IMPLEMENTASI KNOWLEDGE MANAGEMENT PADA KLPM-PTS: PEMBENTUKAN SHARING CULTURE ANTAR ANGGOTA KLPM-PTS DI INDONESIA

, 2012
Tulisan ini merupakan gagasan untuk mengimplementasikan suatu sistem manajemen pengetahuan sebagai tindakan nyata dalam upaya optimasi perguruan tinggi swasta (PTS) dalam pengembangan SDM nasional.
Maryani Maryani, Maryani, Maryani, Maryani, M. (Maryani)   +2 more
core   +1 more source

Click chemistry-based dual nanosystem for microRNA-122 detection with single-base specificity from tumour cells

Journal of Nanobiotechnology
MicroRNAs (miRNAs) have been recognised as potential biomarkers due to their specific expression patterns in different biological tissues and their changes in expression under pathological conditions. MicroRNA-122 (miR-122) is a vertebrate-specific miRNA
Agustín Robles-Remacho, Ismael Martos-Jamai, Mavys Tabraue-Chávez, Araceli Aguilar-González, Jose A. Laz-Ruiz, M. Victoria Cano-Cortés, F. Javier López-Delgado, Juan J. Guardia-Monteagudo, Salvatore Pernagallo, Juan J. Diaz-Mochon, Rosario M. Sanchez-Martin   +10 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Pharmacological Characterization of a Novel ENaCα siRNA (GSK2225745) With Potential for the Treatment of Cystic Fibrosis

Molecular Therapy: Nucleic Acids, 2013
Lung pathology in cystic fibrosis is linked to dehydration of the airways epithelial surface which in part results from inappropriately raised sodium reabsorption through the epithelial sodium channel (ENaC).
Kenneth L Clark, Stephen A Hughes, Pallav Bulsara, Jill Coates, Kitty Moores, Joel Parry, Michael Carr, Ruth J Mayer, Paul Wilson, Chris Gruenloh, Daren Levin, Jill Darton, Wolf-Michael Weber, Katja Sobczak, Deborah R Gill, Stephen C Hyde, Lee A Davies, Ian A Pringle, Stephanie G Sumner-Jones, Vasant Jadhav, Sharon Jamison, Walter R Strapps, Victoria Pickering, Mark R Edbrooke   +23 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The mannose phosphotransferase system (Man-PTS) - Mannose transporter and receptor for bacteriocins and bacteriophages.

, 2020
Mannose transporters constitute a superfamily (Man-PTS) of the Phosphoenolpyruvate Carbohydrate Phosphotransferase System (PTS). The membrane complexes are homotrimers of protomers consisting of two subunits, IIC and IID.
Jeckelmann, Jean-Marc, Erni, Bernhard
core   +1 more source

Key steps and methods in the experimental design and data analysis of highly multi-parametric flow and mass cytometry

Computational and Structural Biotechnology Journal, 2020
High-dimensional, single-cell cell technologies revolutionized the way to study biological systems, and polychromatic flow cytometry (FC) and mass cytometry (MC) are two of the drivers of this revolution.
Paulina Rybakowska, Marta E. Alarcón-Riquelme, Concepción Marañón   +2 more
doaj   +1 more source

Editorial - PT

PORTO ARTE: Revista de Artes Visuais, 2017
Equipe ...
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source