Results 61 to 70 of about 350,979 (277)
Knee Surgery & Related Research, 2021 Background The posterior tibial slope (PTS) is crucial in knee joint stability and in maintaining the natural movement of the knee. An increase in the PTS is associated with various knee pathologic conditions, such as anterior cruciate ligament (ACL ...
Wazzan S. Aljuhani +4 more
doaj +1 more source
Preventing Violence in the Homes of Military Families [PDF]
, 2013 The wars in Iraq and Afghanistan, Operation Iraqi Freedom and Operation Enduring Freedom (OIF/OEF), have demanded unprecedented service at every level of the U.S. Army, Air Force, Navy, and Marines. For the first time in our military history, active duty,
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Nucleobase Stacking Sustained by Pt−Pt Interactions
ChemistryEuropeAbstractThis article reports the use of metal–metal interactions as a way to induce nucleobase stacking in a dinucleotide chain. We synthetized and study a series of C,N‐cyclometallated platinum(II) binuclear complexes derived from 6‐phenylpurine dinucleotide 1 as proligand, and β‐diketonates, 2,2'‐bipyridines and 1,10‐phenanthroline as ancillary ...
Carmen Lorenzo‐Aparicio +4 more
openaire +3 more sources
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Therapy: Nucleic Acids, 2018 Integration-defective lentiviral vectors (IDLVs) have become an important alternative tool for gene therapy applications and basic research. Unfortunately, IDLVs show lower transgene expression as compared to their integrating counterparts. In this study,
Sabina Sánchez-Hernández +15 more
doaj +1 more source
PT-Rotations, PT-Spherical Harmonics and the PT-Hydrogen Atom
, 2010 We have constructed a set of non-Hermitian operators that satisfy the commutation relations of the SO(3)-Lie algebra. It is shown that this operators generate rotations in the configuration space and not in the momentum space but in a modified non-Hermitian momentum space.
Romero, Juan M. +2 more
openaire +2 more sources
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Epigenetic changes produced in women victims of intimate partner violence: A systematic review
Women's HealthBackground: Intimate partner violence (IPV) is a prevalent form of violence against women that encompasses physical, sexual, and emotional abuse, as well as controlling behaviors by intimate partners, and predisposes the victims to multiple diseases ...
Coral González-Martínez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source