Results 71 to 80 of about 350,979 (277)

Abstract objects: Species, Kinds, Concepts [PDF]

open access: yes, 2016
In the paper I present Kotarbiński’s approach to abstract objects and show some mistakes in his investigations. By formal ontology I try to explain Kotarbiński’s view and proffer a new solution, a formal solution that is – I hope – in the spirit of Lvov ...
Kaczmarek, Janusz
core   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Exosomal miRNA profile as complementary tool in the diagnostic and prediction of treatment response in localized breast cancer under neoadjuvant chemotherapy

open access: yesBreast Cancer Research, 2019
Background Breast cancer patients under neoadjuvant chemotherapy includes a heterogeneous group of patients who eventually develop distal disease, not detectable by current methods.
Alba Rodríguez-Martínez   +13 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

open access: yesMolecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone   +11 more
wiley   +1 more source

PT-PT Synthetic Speech Detection

open access: yes
Recent developments in the field of artificial intelligence (AI) have led to the creation of powerful generative models. These models have demonstrated such capabilities that it becomes nearly impossible for a human to distinguish between generated and human utterances, between synthetic and natural speech.
Rafael Geraldo dos Santos   +2 more
openaire   +3 more sources

Development of bismuth-based solutions for well plugging and abandonment: A review

open access: yesPetroleum Research
Plugging and abandonment (P&A) is a crucial step of the well life cycle. Regardless of how long one stretches the productive life of a well, P&A operations will have to be carried out eventually.
Lewaa Hmadeh   +3 more
doaj   +1 more source

Profiles of Emotion Regulation: Understanding Regulatory Patterns and The Implications for Posttraumatic Stress [PDF]

open access: yes, 2017
Trauma survivors often experience posttraumatic stress (PTS) and report concurrent difficulties with emotion regulation (ER). Although individuals typically use multiple regulatory strategies to manage emotion, no studies yet examine the influence of a ...
Chesney, Samantha, Gordon, Nakia
core   +1 more source

Asymptotic mean stationarity and absolute continuity of point process distributions

open access: yes, 2013
This paper relates - for point processes $\Phi$ on $\mathbb{R}$ - two types of asymptotic mean stationarity (AMS) properties and several absolute continuity results for the common probability measures emerging from point process theory. It is proven that
Nieuwenhuis, Gert
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Malignant phyllodes tumors display mesenchymal stem cell features and aldehyde dehydrogenase/disialoganglioside identify their tumor stem cells. [PDF]

open access: yes, 2014
IntroductionAlthough breast phyllodes tumors are rare, there is no effective therapy other than surgery. Little is known about their tumor biology.
Chou, Fen-Pi   +9 more
core   +3 more sources

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