Results 81 to 90 of about 350,979 (277)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A model including CD15, ACE2 and age efficiently predicts COVID-19 severity

Scientific Reports
The COVID-19 pandemic presents a spectrum of clinical outcomes ranging from respiratory conditions to cardiovascular complications that challenge management and resource allocation. Identification of early predictive biomarkers that are easy to detect is
Sergio Cuenca-López, Ana Pozo-Agundo, Carmen María Morales-Álvarez, Verónica Arenas-Rodríguez, Silvia Martínez-Diz, Cristina Lucía Dávila-Fajardo, María Jesús Álvarez-Cubero, Luis Javier Martínez-González   +7 more
doaj   +1 more source

Various ordered states in a 2D interacting electron system close to an electronic topological transition

, 1999
We consider a 2D electron system on a square lattice with hopping beyond nearest neighbors. The existence of the quantum critical point associated with an electronic topological transition in the noninteracting system results in density wave (DW) and ...
Bouis, F., Kiselev, M. N., Onufrieva, F., Pfeuty, P.   +3 more
core   +1 more source

Sensitivity Analysis for a Scenario-Based Reliability Prediction Model [PDF]

, 2005
As a popular means for capturing behavioural requirements, scenariosshow how components interact to provide system-level functionality.If component reliability information is available, scenarioscan be used to perform early system reliability assessment.
Rodrigues, G, Rosenblum, D, Uchitel, S
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Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Isolation of Murine Adipose Tissue-derived Mesenchymal Stromal Cells (mASCs) and the Analysis of Their Proliferation in vitro

Bio-Protocol, 2015
Mesenchymal stromal cells (MSCs) are non-hematopoietic, perivascular cells which support hematopoiesis and are thought to participate in tissue repair in vivo.
Per Anderson, Ana Carrillo-Gálvez, Francisco Martín   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

MiRNA expression as outcome predictor in pediatric AML: systematic evaluation of a new model

npj Genomic Medicine
Accurately predicting patient outcomes is essential for optimizing treatment and improving outcomes in pediatric acute myeloid leukemia (AML). In recent years, microRNAs have emerged as a promising prognostic marker, with a growing body of evidence ...
Ivan Ellson, Jordi Martorell-Marugán, Pedro Carmona-Sáez, Verónica Ramos-Mejia   +3 more
doaj   +1 more source

Crosstalk Between Autophagy and Oxidative Stress in Hematological Malignancies: Mechanisms, Implications, and Therapeutic Potential

Antioxidants
Autophagy is a fundamental cellular process that maintains homeostasis by degrading damaged components and regulating stress responses. It plays a crucial role in cancer biology, including tumor progression, metastasis, and therapeutic resistance ...
Antonio José Cabrera-Serrano, José Manuel Sánchez-Maldonado, Carmen González-Olmedo, María Carretero-Fernández, Leticia Díaz-Beltrán, Juan Francisco Gutiérrez-Bautista, Francisco José García-Verdejo, Fernando Gálvez-Montosa, José Antonio López-López, Paloma García-Martín, Eva María Pérez, Pedro Sánchez-Rovira, Fernando Jesús Reyes-Zurita, Juan Sainz   +13 more
doaj   +1 more source

Clinical application of penicillin [PDF]

, 1949
Mostly reprintsIncludes bibliographical references.10 pts. in 1 v.Title page and introduction only. The complete thesis in print form is available from the University Library.Thesis (M.D.)--University of Adelaide, Dept.
Florey, Mary Ethel Hayter (Reed), Lady
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