Results 101 to 110 of about 2,220,873 (330)
Prolonged maturation of prefrontal white matter in chimpanzees [PDF]
, 2010 Delayed maturation in the prefrontal cortex, a brain region associated with complex cognitive processing, has been proposed to be specific to humans.Akichika Mikami, Daichi Hirai, Haruyuki Makishima, Juri Suzuki, Masaki Tomonaga, Masato Nakatsukasa, Masayuki Tanaka, Takako Miyabe-Nishiwaki, Tetsuro Matsuzawa, Tomoko Sakai, Yuzuru Hamada +10 morecore +1 more sourceThe multiple hit model of infantile and epileptic spasms: The 2025 update
Epilepsia Open, EarlyView.Abstract Objective
Infantile and epileptic spasms syndrome (IESS) is a developmental and epileptic encephalopathy manifesting with epileptic spasms and poor neurodevelopmental outcomes. There is an urgent need for the development of more effective and tolerated therapies.Aristea S. Galanopoulou, Wenzhu B. Mowrey, Wei Liu, Anna Maria Katsarou, Qianyun Li, Oleksii Shandra, Solomon L. Moshé +6 morewiley +1 more sourceImplantable drug delivery system: Frontiers of medicine‐engineering interdisciplinary
Interdisciplinary Medicine, EarlyView.This review systematically summarizes the driving mechanisms of implantable on‐demand drug delivery systems (IDDS), including endogenous, exogenous, and closed‐loop strategies. It highlights the pivotal roles of flexible electronics and miniaturization in enhancing the tissue conformity and spatial adaptability.Yu Zeng, Rongtai Su, Manyu Zhao, Xin Song, Ran Liu, Yuhao Zhou, Chaojuan Yang, Yanli Jiao, Xiao‐Wei Xiang, Lingqian Chang +9 morewiley +1 more sourceParent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. [PDF]
, 2014 Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.A Kong, A Lomniczi, A Murphy, A Schröder, AA D’Aloisio, Aarno Palotie, AB Migliano, Adamo Pio D’adamo, Aida K. Dieffenbach, AL Dixon, Albert Hofman, Albert V. Smith, Albertine J. Oldehinkel, Alexander Teumer, Alison M. Dunning, Andrea D. Coviello, Andrea Ganna, Andres Metspalu, Andrew C. Heath, Andrew D. Johnson, André G. Uitterlinden, Angela Cox, Anja Rudolph, Anna M. Storniolo, Anna Murray, Anneli Pouta, Annika Lindblom, Antonietta Robino, AP Abreu, Arto Mannermaa, AS Dimas, AV Segrè, B Kabakchiev, B Zhang, BE Stranger, Behrooz Z. Alizadeh, Ben A. Oostra, Bernardo Bonanni, Bjarke Feenstra, BP Fairfax, Bruce H. R. Wolffenbuttel, C Colantuoni, C Liu, C-J Partsch, Carl Blomqvist, Catharina A. Hartman, Cathy E. Elks, CE Elks, Christian Gieger, Chunyan He, CJ Willer, Cornelia M. van Duijn, CP Schaaf, Craig E. Pennell, D Mehta, D Sasayama, DA Cusanovich, Daniel F. Gudbjartsson, Daniel I. Chasman, Daniel L. Koller, David Couper, David J. Hunter, David Karasik, David P. Strachan, David Schlessinger, Debbie Lawlor, Deborah J. Thompson, Diana L. Cousminer, Dieter Flesch-Janys, Diether Lambrechts, Dirkje S. Postma, DM Greenawalt, Doris Stöckl, Dorret I. Boomsma, Douglas F. Easton, Douglas P. Kiel, E Grundberg, E Grundberg, E Grundberg, Eco E. J. de Geus, EE Schadt, EK Speliotes, EL Heinzen, Eleonora Porcu, Elisabeth Widen, Elizabeth A. Streeten, Ellen A. Nohr, Ellen W. Demerath, Emmi Tikkanen, Enda M. Byrne, Eric Boerwinkle, Erik Ingelsson, Erin K. Wagner, Eva Albrecht, Evelin Mihailov, F Innocenti, F Nagl, F Zou, Felix Day, Femke Atsma, Fergus J. Couch, Fernando Rivadeneira, Frank B. Hu, Frank Geller, GA Heap, George Davey Smith, George McMahon, Georgia Chenevix-Trench, Gerard Waeber, Gisli Masson, Gonneke Willemsen, Graham G. Giles, Grant W. Montgomery, Gudmar Thorleifsson, Gudny Eiriksdottir, H Lango Allen, H-J Westra, Harold Snieder, Heather A. Boyd, Heli Nevanlinna, Henri Wallaschofski, Henrik Flyger, Henry Völzke, Hermann Brenner, HHH Göring, Hiltrud Brauch, Hoda Anton-Culver, IK Temple, Ilja M. Nolte, Immaculata De Vivo, Irene L. Andrulis, J Ding, J Huang, J Yang, J Yang, J Yang, J. Margriet Collée, JA Webster, Javier Benitez, JC Barrett, Jenny A. Visser, Jenny Chang-Claude, JF Degner, Jing Hua Zhao, Jinhui Chen, Joanne M. Murabito, Joe Dennis, Johan G. Eriksson, John L. Hopper, John P. Rice, John R. B. Perry, Jonathan Tyrer, Jouke-Jan Hottenga, JR Gibbs, Julia A. Knight, Julian Peto, Julie E. Buring, K Estrada, K Hao, K Michailidou, Kamila Czene, Kari Stefansson, Kathryn L. Lunetta, Katri Pylkäs, Kay-Tee Khaw, Ken K. Ong, KS Kompass, Kyriaki Michailidou, L Liang, Laura Crisponi, Laura J. Bierut, Laura M. Yerges-Armstrong, Lavinia Paternoster, LB Barreiro, LFG Silveira, Lili Milani, Lisette Stolk, Lude Franke, Luigi Ferrucci, Lynda M. Rose, M Horikoshi, M Rantalainen, Maartje J. Hooning, Mads Melbye, Manjeet K. Bolla, Marek Zygmunt, Margaret J. Wright, Marjanka K. Schmidt, Marjo-Riitta Järvelin, Mark I. McCarthy, Massimo Mangino, Matthias W. Beckmann, Meir J. Stampfer, Melanie Waldenberger, Melissa E. Garcia, Mellissa C. Southey, Michael J. Econs, Montserrat García-Closas, Munro Peacock, N Ruf, Najaf Amin, Nancy L. Pedersen, Natalia Tšernikova, Nicholas G. Martin, Nicholas J. Timpson, Nicholas J. Wareham, Nora Franceschini, P Prentice, Paolo Gasparini, Paolo Peterlongo, Paolo Radice, Pascal Guénel, Patrick F. McArdle, Patrick Neven, Patrick Sulem, Patrik K. Magnusson, Paul D. P. Pharoah, Paul M. Ridker, Per Hall, Peter A. Fasching, Peter Devilee, Peter Kraft, Peter Vollenweider, Q Li, Qin Wang, Reedik Mägi, Robert Winqvist, Robin Haring, Roger L. Milne, RP Grinspon, RS Huang, RSN Fehrmann, Ruth J. F. Loos, S Cho, S Constantin, S Sulzbacher, Sandra Lai, Sanela Kjellqvist, SE Parker, Serena Sanna, Sheila Ulivi, Stefania Bandinelli, Stephen Chanock, Stig E. Bojesen, Suiqun Guo, Susan Ring, Sven Bergmann, T Kwan, T Maeda, T Zeller, Tamara B. Harris, Tanguy Corre, Tatiana Foroud, Teresa Ferreira, Thorkild I. A. Sørensen, Tim D. Spector, Tune H. Pers, Tõnu Esko, Ulla Sovio, Unnur Thorsteinsdottir, Ute Hamann, V Emilsson, Veikko Salomaa, Veli-Matti Kosma, Vilmundur Gudnason, W Zheng, Wei Q. Ang, Wendy L. McArdle, Y Idaghdour, Y Stelzer, Z Zadik, Zoltan Kutalik +271 morecore +7 more sourcesSteroidopathies and hormonal imbalance in children and adolescents with autism spectrum disorder
JCPP Advances, EarlyView.Abstract Background
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental condition with a multifactorial etiology, many aspects of which remain unclear. Emerging evidence suggests a potential association between ASD and clinical manifestations resulting from hormonal imbalances, henceforth named “steroidopathies.” The present study aims to ...Concetta de Giambattista, Patrizia Ventura, Samuele Cortese, Paolo Trerotoli, Alessandra Di Gioia, Lucia Margari +5 morewiley +1 more sourceAlternate-day fasting delays pubertal development in normal-weight mice but prevents high-fat diet-induced obesity and precocious puberty
Nutrition & DiabetesBackground/Objectives Childhood obesity, particularly in girls, is linked to early puberty onset, heightening risks for adult-onset diseases. Addressing childhood obesity and precocious puberty is vital to mitigate societal burdens.Rahim Ullah, Chuqing Xue, Senjie Wang, Zhewen Qin, Naveed Rauf, Shumin Zhan, Naimat Ullah Khan, Yi Shen, Yu-Dong Zhou, Junfen Fu +9 moredoaj +1 more sourceA survey of chromosome anomalies in Malta [PDF]
, 1989 433 individuals referred for chromosome analysis between 1983 and 1987 were included in the survey. Among individuals with dysmorphic features or congenital anomalies 42% of babies referred in the neonatal period and 12 to 30% of individuals in older age Cuschieri, Alfred, Gauci, Sandracore Timing of maternal exposure and fetal sex determine the effects of low-level chemical mixture exposure on the fetal neuroendocrine system in sheep [PDF]
, 2016 We have shown that continuous maternal exposure to the complex mixture of environmental chemicals (ECs) found in human biosolids (sewage sludge), disrupts mRNA expression of genes crucial for development and long-term regulation of hypothalamo-pituitary ...Bellingham, M., Cotinot, C., Evans, N.P., Fowler, P.A., MacDonald, E.S., Mandon-Pepin, B., Rhind, S., Sharpe, R.M. +7 morecore +2 more sources
