Results 11 to 20 of about 1,980,181 (285)

Delayed Puberty and Its Association With Hormonal Changes in Children With Chronic Renal Insufficiency

Acta Medica Iranica, 2022
Chronic kidney diseases affect sex hormones, and thus it is now hypothesized abnormal puberty phenomenon in adolescents suffering renal failure. The primary study endpoint was to assess the frequency of disorders related to the clinical incidence of ...
Davood Amirkashani, Nakisa Hooman, Mohaddese Shahidzadeh   +2 more
doaj   +1 more source

Genetic, epigenetic and enviromental influencing factors on the regulation of precocious and delayed puberty

Frontiers in Endocrinology, 2022
The pubertal development onset is controlled by a network of genes that regulate the gonadotropin releasing hormone (GnRH) pulsatile release and the subsequent increase of the circulating levels of pituitary gonadotropins that activate the gonadal ...
M. Faienza, F. Urbano, L. Moscogiuri, M. Chiarito, S. De Santis, P. Giordano   +5 more
semanticscholar   +1 more source

MANAGEMENT OF ENDOCRINE DISEASE: Diagnosis and management of primary amenorrhea and female delayed puberty

European Journal of Endocrinology, 2021
Puberty is the period of transition from childhood to adulthood characterized by the attainment of adult height and body composition, accrual of bone strength and the acquisition of secondary sexual characteristics, psychosocial maturation and ...
Satu Seppä, Tanja Kuiri-Hänninen, E. Holopainen, R. Voutilainen   +3 more
semanticscholar   +1 more source

FSH stimulated inhibin B (FSH-iB): A novel marker for the accurate prediction of pubertal outcome in delayed puberty.

Journal of Clinical Endocrinology and Metabolism, 2021
BACKGROUND Clinicians have long been struggling to find an effective tool to predict onset of puberty. OBJECTIVE To explore stimulability of inhibin B after exogenous FSH and it's potential role for prediction of onset of puberty.
S. Chaudhary, R. Walia, A. Bhansali, D. Dayal, N. Sachdeva, Tulika Singh, S. Bhadada   +6 more
semanticscholar   +1 more source

Frasier Syndrome: A 15-Year-Old Phenotypically Female Adolescent Presenting with Delayed Puberty and Nephropathy

Children, 2023
Frasier syndrome (FS) is a rare inherited disorder characterized by gonadal dysgenesis and progressive nephropathy, resulting from mutations in the intron 9 splice donor site of the Wilms tumor 1 (WT1) gene. It is associated with male gonadal dysgenesis (
Qing Shao, Xinglei Xie, Jia Geng, Xiaoling Yang, Wei Li, Yuwei Zhang   +5 more
doaj   +1 more source

Genetic evaluation supports differential diagnosis in adolescent patients with delayed puberty

European Journal of Endocrinology, 2021
Context Pubertal delay can be the clinical presentation of both idiopathic hypogonadotropic hypogonadism (IHH) and self-limited delayed puberty (SLDP).
T. Saengkaew, Heena R Patel, K. Banerjee, G. Butler, M. Dattani, M. McGuigan, H. Storr, R. Willemsen, L. Dunkel, S. Howard   +9 more
semanticscholar   +1 more source

Congenital hypogonadotropic hypogonadism: from clinical characteristics to genetic aspects [PDF]

Precision and Future Medicine, 2021
Congenital hypogonadotropic hypogonadism (CHH) is a rare disorder caused by a deficiency in gonadotropin-releasing hormone (GnRH). CHH is characterized by delayed puberty and/or infertility; this is because GnRH is the main component of the hypothalamic ...
Ahreum Kwon, Ho-Seong Kim
doaj   +1 more source

Insulin-like peptide 3 (INSL3) in congenital hypogonadotrophic hypogonadism (CHH) in boys with delayed puberty and adult men

Frontiers in Endocrinology, 2022
BackgroundDelayed puberty in males is almost invariably associated with constitutional delay of growth and puberty (CDGP) or congenital hypogonadotrophic hypogonadism (CHH).
Ali Abbara, Ali Abbara, Kanyada Koysombat, Maria Phylactou, Maria Phylactou, Pei Chia Eng, Pei Chia Eng, Sophie Clarke, Sophie Clarke, Alexander N. Comninos, Alexander N. Comninos, Lisa Yang, Lisa Yang, Chioma Izzi-Engbeaya, Chioma Izzi-Engbeaya, Simon Hanassab, Simon Hanassab, Neil Smith, Channa N. Jayasena, Channa N. Jayasena, Cheng Xu, Cheng Xu, Richard Quinton, Richard Quinton, Nelly Pitteloud, Nelly Pitteloud, Gerhard Binder, Ravinder Anand-Ivell, Richard Ivell, Waljit S. Dhillo, Waljit S. Dhillo   +30 more
doaj   +1 more source

Whole exome sequencing identifies deleterious rare variants in CCDC141 in familial self-limited delayed puberty

npj Genomic Medicine, 2021
Developmental abnormalities of the gonadotropin-releasing hormone (GnRH) neuronal network result in a range of conditions from idiopathic hypogonadotropic hypogonadism to self-limited delayed puberty.
Tansit Saengkaew, Gerard Ruiz-Babot, Alessia David, Alessandra Mancini, Katia Mariniello, Claudia P. Cabrera, Michael R. Barnes, Leo Dunkel, Leonardo Guasti, Sasha R. Howard   +9 more
doaj   +1 more source

Key features of puberty onset and progression can help distinguish self-limited delayed puberty from congenital hypogonadotrophic hypogonadism

Frontiers in Endocrinology, 2023
IntroductionDelayed puberty (DP) is a frequent concern for adolescents. The most common underlying aetiology is self-limited DP (SLDP). However, this can be difficult to differentiate from the more severe condition congenital hypogonadotrophic ...
Yuri Aung, Yuri Aung, Vasilis Kokotsis, Kyla Ng Yin, Kausik Banerjee, Gary Butler, Gary Butler, Mehul T. Dattani, Mehul T. Dattani, Mehul T. Dattani, Paul Dimitri, Leo Dunkel, Claire Hughes, Michael McGuigan, Márta Korbonits, Márta Korbonits, George Paltoglou, Sophia Sakka, Pratik Shah, Pratik Shah, Helen L. Storr, Helen L. Storr, Ruben H. Willemsen, Sasha R. Howard, Sasha R. Howard   +24 more
doaj   +1 more source