Results 111 to 120 of about 19,606 (282)

‘We Need Help Too’—The Forgotten Stakeholders: Exploring the Needs of Carers During Their Young Persons' Transition From Child to Adult Eating Disorder Services

European Eating Disorders Review, EarlyView.
ABSTRACT Background Carers are essential in their young person's recovery during transition from child to adult eating disorder services. Despite recommendations, carer's own needs can be overlooked in transition planning. Subsequently, carers experience distress in supporting their young person and navigating the transition.
Isabel Lenham, Maria Livanou, Anya Heneghan, Grace Hill, Alanta McKenzie, Marta Marlais, Francesca Marshall, Zara Smalley, Eleni Xanthopoulou, Nora Kornai, Jessica Wilks, Ailsa McKay, Jun Teh, Julian Baudinet   +13 more
wiley   +1 more source

Patients’ and researchers’ experiences with a patient board for a clinical trial on urinary tract infections

Research Involvement and Engagement, 2019
Background Patient and public involvement (PPI) has become an essential part of the design, conduct, and dissemination of research. While researchers who employed PPI mainly report on the positive aspects, in practice PPI is still an exception in ...
Imke Schilling, Heike Behrens, Jutta Bleidorn, Ildikó Gágyor, Claudia Hugenschmidt, Hannah Jilani, Guido Schmiemann, Ansgar Gerhardus   +7 more
doaj   +1 more source

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration, EarlyView.
The deficiency of PNLDC1 exacerbates the advancement of CRC. PNLDC1 interacts with TUBB4B mRNA to regulate the p53–p21–CDK2–cyclin E2 pathway, thereby influencing the G2/M phase of the cell cycle. ABSTRACT Colorectal cancer (CRC) remains a leading cause of cancer‐related mortality, highlighting the urgent need for novel therapeutic strategies.
Lexin Liu, Yuelin Guan, Yuzhou Qin, Guiping Chen, Guozhen Wang, Xiang Yan, Xue Li, Lei Sun, Wei Yu, Shi Ouyang, Zhichao Ma, Zihao Xu, Zhongkai Cao, Fan Yu, Tong Zhou, Ziyou Luo, Xiangjun Chen, Yongbin Yan, Lidan Hu   +18 more
wiley   +1 more source

What Can Providers' Motivations Tell Us About Healthcare Quality?

Health Economics, EarlyView.
ABSTRACT Agency theory suggests that variation in providers' quality of care may be explained by their heterogeneous motivations. We provide novel empirical evidence on the links between different sources of provider motivation and quality of care by combining a unique 4‐year survey dataset on Danish general practitioners' motivations with quality ...
Lucy Margaret Poole, Line Bjørnskov Pedersen, Anne Sophie Oxholm   +2 more
wiley   +1 more source

Methods of Engaging Interest‐Holders in Healthcare Evidence Syntheses: A Scoping Review

Cochrane Evidence Synthesis and Methods
Introduction Engaging interest‐holders in health care evidence syntheses may make evidence syntheses more relevant, useful, and accessible. However, the best way(s) to engage interest‐holders within the evidence synthesis process remain unknown.
Alex Todhunter‐Brown, Jennifer Petkovic, Christine Chang, Ursula Griebler, Ailish Hannigan, Jennifer Hilgart, Basharat Hussain, Janet Jull, Christina Koscher‐Kien, Dominic Ledinger, Barbara Nussbaumer‐Streit, Oyekola Oloyede, Eve Tomlinson, Shoba Dawson, Omar Dewidar, Sean Grant, Lyubov Lytvyn, Thomas W. Concannon, Leonila Dans, Denny John, Zoe Jordan, Evan Mayo‐Wilson, Chris McCutcheon, Francesco Nonino, Danielle Pollock, Karine Toupin April, Pauline Campbell, Joanne Khabsa, Olivia Magwood, Vivian Welch, Peter Tugwell   +30 more
doaj   +1 more source

The Effects of Monetary Policy in the United Kingdom: New Evidence From SONIA Market Responses

International Journal of Finance &Economics, EarlyView.
ABSTRACT This paper constructs a new measure of the UK monetary policy instrument (MPI) using daily changes in the sterling overnight index average (SONIA) around Bank of England policy events from June 1997 to August 2025. The instrument explicitly accounts for pre‐event information and unconventional monetary policy (UMP) using lagged macro‐financial
Ayobami E. Ilori, Lucia M. Murgia
wiley   +1 more source

Exploring the role of Patient and Public Involvement in Implementation Research using the Study of Implementation of Midwifery Continuity of Carer (SIMCA). [version 2; peer review: 2 approved]

NIHR Open Research
Background Patient and Public Involvement (PPI) is a fundamental part of health research. The role of PPI in implementation research, which considers the transfer of evidence into practice, is often less well defined than in studies focussing on ...
Heather Strange, Aimee Middlemiss, Lena Choudary-Salter, Kate Davies, Tina Prendeville, Susan Barry, Rebecca Milton, Julia Sanders, Aled Jones, Sara Kenyon, Susan Channon   +10 more
doaj   +1 more source

Immune‐Related Prognostic Gene Identification in Lung Squamous Cell Carcinoma With the Cancer Genome Atlas Mining and Immunohistochemistry Validation

iNew Medicine, EarlyView.
ABSTRACT Objective In the cancer microenvironment, stromal and immune cells hold clinical importance. In lung squamous cell carcinoma (LSCC), the aim of this study was to find immune‐linked gene expression that has prognostic pertinence. Methods From the Cancer Genome Atlas, this study obtained the LSCC gene expression profile.
Weijia Jiang, Jing Xu, Wenwen Ma, Qingjie Zhu, Pawin Pongkorpsakol, Guoping Sun   +5 more
wiley   +1 more source

TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia

CNS Neuroscience &Therapeutics, EarlyView., 2023
Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi, Decheng Ren, Fan Yuan, Zhou Zhang, Daizhan Zhou, Xin Yi, Lei Ji, Keyi Li, Fengping Yang, Xi Wu, Xingwang Li, Yifeng Xu, Yun Liu, Peng Wang, Changqun Cai, Chuanxin Liu, Qian Ma, Lin He, Yi Shi, Guang He   +19 more
wiley   +1 more source

Co‐design of a complex school‐based intervention for attention deficit/hyperactivity disorder using the Intervention Mapping approach

JCPP Advances, EarlyView.
Abstract Background Attention deficit/hyperactivity disorder (ADHD) is a highly heritable neurodevelopmental condition, comprising varying difficulties in attention and/or impulsive and overly active behaviours, with knock on effects for health, learning, social and emotional functioning, self‐esteem and quality of life.
Abigail Russell, Suzie Holt, Ian Wellaway, Ali Hirst, Lynne Heaney, Rachel Hanna, James Wenger, Liz Hampton, Barry Sullivan, Fran Townsend, Tamsin Ford, Barnaby D. Dunn, Darren Moore, Edmund Sonuga‐Barke, Linda Pfiffner, Judi Kidger, Rachel Hayes, Rebecca Gudka, Eleanor Bryant, Kirsty Cordwell, the Tools for Schools Planning Group   +20 more
wiley   +1 more source