Results 131 to 140 of about 19,606 (282)

How Can We Enhance Patient and Public Involvement and Engagement in Nursing Science?

Nursing Reports
Patient and Public Involvement and Engagement (PPIE, alternatively referred to as public involvement (PI), public and patient involvement (PPI), or consumer and community involvement and engagement (CCIE)), refers to research being conducted ‘with’ or ...
Richard Gray, Noppamas Pipatpiboon, Daniel Bressington   +2 more
doaj   +1 more source

Identification of Predictive Signatures for Osimertinib‐Associated Interstitial Lung Disease: Integrating Ensemble Machine Learning and Temporal Dynamics

Medicine Bulletin, EarlyView.
ABSTRACT The shift toward chronic management of EGFR‐mutant lung cancer underscores the urgent need to identify molecular features potentially relevant to osimertinib‐associated interstitial lung disease (ILD). This study aimed to investigate candidate molecular mechanisms of this toxicity by integrating putative osimertinib target profiles with ILD ...
Yilin Ye, Lianxin Zhu, Yunxiang Xie, Peng Sun, Cui Chen, Zhihua Zhu   +5 more
wiley   +1 more source

Artificial Intelligence for Identifying Tumor‐Reactive CD8+ T Cells: Biological Principles, Computational Advances, and Future Directions

Med Research, EarlyView.
This review details a three‐stage paradigm shift for tumor‐reactive CD8+ T‐cell identification: decoding transcriptomic states, deciphering clonal functional efficacy, and molecular‐level therapeutic TCR design. Addressing translational hurdles and generative AI “scientific blind spots”—such as missing catch bonds—we present a visionary roadmap.
Chao Yang, Yingying Sun, Yan Zhang, Yifen Shi, Zhiwen Shi   +4 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Estimating the smallest worthwhile difference of antidepressants: a cross-sectional survey

BMJ Mental Health
Background Approximately 30% of patients experience substantial improvement in depression after 2 months without treatment, and 45% with antidepressants. The smallest worthwhile difference (SWD) refers to an intervention’s smallest beneficial effect over
Toshi A Furukawa, Andrea Cipriani, Yan Luo, Georgia Salanti, Manuela L Ferreira, Astrid Chevance, Sarah Markham, Ethan Sahker, Roger Ede, Kaori Okazaki   +9 more
doaj   +1 more source

Predictors of Recurrent Croup: The Role of Social Determinants of Health and Otolaryngology Evaluation

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To evaluate the influence of patient comorbidities, social determinants of health (SDOH), and otolaryngology (OTO) referral timing on disease course and healthcare utilization among pediatric patients with recurrent croup. Study Design Retrospective cohort study. Setting Large tertiary children's hospital. Methods Pediatric patients (
Wesley P. Allen, Katie Hansen, Freddy A. Espinoza, Brandon M. Hemeyer, Jb Eyring, Tanner Heaton, Brock Coleman, Jeremy Meier, Reema Padia   +8 more
wiley   +1 more source

Exploring the Reproductive Toxicity of Bisphenol S Through a Network Toxicology and Molecular Docking Analysis

Pediatric Discovery, EarlyView.
Utilizing network toxicology, molecular docking, and dynamic simulations to investigate the potential reproductive toxicity of bisphenol S (BPS). ABSTRACT The aim of this study was to investigate the potential reproductive toxicity of bisphenol S (BPS) and the related molecular mechanisms through a network toxicology approach.
Siyuan Wang, Yan Fu, Xu Huang, Qitong Guo, Xiangqin Zheng, Shengde Wu, Lianju Shen, Guanghui Wei   +7 more
wiley   +1 more source

Identification of Novel Interacting Proteins of FUZ and GPR161

PROTEOMICS, EarlyView.
ABSTRACT Protein–protein interactions are central to the dynamic regulation of signaling pathways and provide critical insight into the cellular mechanisms underlying human disease. Our previous study demonstrated biochemical and genetic interactions between FUZ and GPR161 in sonic hedgehog signaling during spinal neural tube development. In this study,
Gabriella Salazar, Anna Battenhouse, Andrew J. Kim, Sung‐Eun Kim   +3 more
wiley   +1 more source

Betulinic Acid Enema Alleviates Colitis by Targeting Vitamin D Receptor to Protect the Intestinal Mucosal Barrier and Modulate Mucosa‐Associated Microbiota

Phytotherapy Research, EarlyView.
ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory disease of the colon with limited effectiveness and safety of current drug therapies. Betulinic acid (BA) is a naturally occurring pentacyclic triterpenoid present in traditional Chinese medicines used clinically as retention enemas for UC, but its direct effects and mechanisms remain unclear ...
Lina Dong, Yuanxia Gao, Qian Li, Guangxin Chen, Dong Yang, Liping Zhao, Xiaojing Liu, Shumei Lin   +7 more
wiley   +1 more source

Patient and public involvement in the SPRUCE methodology study investigating electronic patient reported outcomes in oncology clinical trials.

BACKGROUND: Patient reported outcomes (PRO) provide crucial insight into trial participants' experience of oncology treatments. At the Clinical Trials and Statistics Unit at the Institute of Cancer Research (ICR-CTSU), these are completed by participants
Hill, E, King, D, Lloyd, L, Dewan, M, Deutsch, A, Radin, E, Gillman, A, Lewis, R, Haviland, J, Stiles, M, Hall, E, Foster, S, Kowalczuk, F, Philipps, L, Manning, G, Gath, J, Watson, K, Huddart, R, Maudsley, J   +18 more
core   +1 more source