Results 71 to 80 of about 1,286,583 (307)
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
DANGER TO PUBLIC HEALTH PROGRAMS IN THE WAKE OF COVID-19
Khyber Medical University Journal, 2020 The time when the world is dealing with corona disaster, there is this fear that we might not forget about other communicable diseases. There are multiple international and national programs in place to prevent these communicable diseases.
Wiqar Ahmad +2 more
doaj +1 more source
Public health and genetics—a dangerous combination? [PDF]
European Journal of Public Health, 2005 ‘It is clear, that the science of genomics holds tremendous potential for improving health globally… The specific challenge is how to harness this knowledge and have it contribute to health equity, especially among developing nations…’ This is a quote by Gro Harlem Brundtland, former Director General of WHO, which can be found in the year 2000 Report ...
openaire +2 more sources
Corruption, Clients, and Political MacHines a Response to Professor Issacharoff [PDF]
, 2011 Responding to Samuel Issacharoff, On Political Corruption, 124 Harv. L. Rev. 118 (2010) In his comment on political corruption, Professor Samuel Issacharoff questions traditional accounts that aim to squeeze money out of politics entirely. Instead,
Sachs, Stephen E.
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Some Issues on Reforming the Legislation on Administrative Offences
Сибирское юридическое обозрение, 2019 Some problems of modern administrative-tort law are considered. Attention is focused on a number of key problems of the current legislation on administrative offenses and on some specific proposals for its amendment.
S. I. Koryts, I. B. Bokova
doaj +1 more source
Individual perception of bees : Between perceived danger and willingness to protect [PDF]
, 2017 The current loss of biodiversity has found its way into the media. Especially the loss of bees as pollinators has recently received much attention aiming to increase public awareness about the consequence of pollinator loss and strategies for protection.
Bogner, Franz X. +1 more
core +3 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
On The Issue of the Categorization of Administrative Offences
Сибирское юридическое обозрение, 2019 Some problems of modern administrative-tort and criminal legislation and law are considered. On the positive side, the sequence of the legislator is assessed regarding the delimitation of the norms of criminal and administrative responsibility. Attention
V. I. Surgutskov
doaj +1 more source