Results 91 to 100 of about 1,286,583 (307)

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

State or Nature? Formal vs. Informal Sanctioning in the Voluntary Provision of Public Goods [PDF]

open access: yes
The sanctioning of norm-violating behavior by an effective formal authority is an efficient solution for social dilemmas. It is in the self-interest of voters and is often favorably contrasted with letting citizens take punishment into their own hands ...
Jean-Robert Tyran   +2 more
core   +6 more sources

The 2010 Comprehensive Spending Review: the economics of the cuts agenda are neither justified nor just . [PDF]

open access: yes
Last week's Comprehensive Spending Review detailed the largest cuts to public spending since the Second World War. In John Van Reenen’s judgement, the speed and scale of the cuts are not economically justified because the previous government’s plans ...
Van Reenen, John
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Monitoring wood decay in poles by the vibroacoustic method [PDF]

open access: yes, 2001
Despite recent advances in the development of new materials, wood continues to be used globally for the support of overhead cable networks used by telecommunications and electrical utility companies.
Craighead, I.A.   +3 more
core   +1 more source

Review of California Wildfire Evacuations from 2017 to 2019 [PDF]

open access: yes, 2020
Between 2017 and 2019, California experienced a series of devastating wildfires that together led over one million people to be ordered to evacuate. Due to the speed of many of these wildfires, residents across California found themselves in challenging ...
Broader, Jacquelyn C.   +2 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Evaluating the Effectiveness of Forensic Psychiatric Prevention [PDF]

open access: yesПсихологическая наука и образование (2007. Online), 2014
We discuss the quantitative indicators, the analysis of which gives an idea of the strengths and means at the disposal of forensic health care. We discuss the possibility of using the existing statistical monitoring system for a dynamic assessment of the
Makushkina O.A., , Bulygina V.G
doaj  

The determinants of urban public transport: an international comparison and econometric analysis [PDF]

open access: yes
The analysis presented in this paper is based on the database created by the UITP (International Association of Public Transport), "The Millennium Cities Database", which covers the public transport systems in 100 of the world's cities.
Iragaël Joly   +2 more
core  

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

open access: yesMolecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor   +2 more
wiley   +1 more source

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