Results 41 to 50 of about 13,145,419 (304)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Work and refugee integration in Sweden
Forced Migration Review, 2014 One of the main challenges facing refugees trying to integrate in their host country is finding a suitable job. Sweden recognises this issue and is investing in making inclusion in the labour market the driver of refugee integration.
Miguel Peromingo
doaj
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
La (des)protección de la propiedad intelectual de las obras del poder público
Revista Vasca de Administración Pública, 2017 This work begins with an analysis about the vulnerability provoked by the intellectual property rules regarding works linked to the exercise of public power (either the legislative, the executive or the judiciary).
Juan Antonio Ureña Salcedo
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Revista Vasca de Administración Pública, 2009 This work analyzes the meaning and scope of the Basic Statute for Civil Servants as adopted by Act 7/2007 from a twofold perspective, its adjustment to the model of Autonomic State and its modernizing aspect. This Basic Statute for Civil Servants answers
Elisenda Malaret i Garcia
doaj +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Studia Iuridica Lublinensia, 2021 The COVID-19 pandemic has significantly affected all spheres of social-political life of the world community. As a result, there have been serious changes in the labour market, including the civil service. The labour market for civil servants is becoming
Іvan Balashov +4 more
doaj +1 more source
Employment in the Public Sector [PDF]
, 2004 This paper presents a model of wage-employment determination in private and public sectors, which allows us to analyze the effects of different institutional arrangements on labor market equilibria. In particular, it focuses on how different degrees of coordination in decision processes affect hiring and wage setting outcomes.
Lorenzo Forni, Raffaela Giordano
openaire +3 more sources