Results 51 to 60 of about 13,145,419 (304)

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Desafíos pendientes para la definitiva implantación de la evaluación del desempeño

Revista Vasca de Administración Pública, 2017
It has been a decade since the Basic Statute of the Public Employee was passed without job evaluation, one of its most important bets to modernize Administration and public employment, has been implemented, nor the necessary foundations for its later ...
Pedro Padilla Ruiz
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Public Service Employment: Full Employment Without Inflation

Problemas del Desarrollo. Revista Latinoamericana de Economía, 2009
For the last few decades, monetary policy has been geared toward raising the unemployment rate as a means of achieving stable prices. However, it is possible to have stable prices as well as full employment, via a federal public service employment (PSE) program that provides jobs for those ready, willing, and able to work at the established wage. Such
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Employment Trends Among Public Health Doctoral Recipients, 2003-2015

, 2018
OBJECTIVES: To examine postgraduation employment trends among graduates of doctoral programs in public health from 2003 to 2015. METHODS: We analyzed pooled cross-sectional data from a census of graduates receiving a research doctorate from US ...
Jackson, Joanna R., Brown-Podgorski, Brittany L., Golembiewski, Elizabeth H., Holmes, Ann M., Menachemi, Nir   +4 more
core   +1 more source

Achieving Employment Equity in the Public Service: A study of changes between 1995 and 2001 [PDF]

, 2002
This paper will seek to analyse the performance of the public sector in implementing affirmative action policies intended to promote employment equity. This will be done primarily by examining the pattern of changes in public sector employment over the ...
Thompson, Keith, Woolard, Ingrid
core   +1 more source

Between Equality and Hierarchy: A Socio-Legal Analysis of Employment Protection for PPPK Under Indonesia’s State Civil Apparatus Reform

Baileo
This study aims to examine the socio-legal paradox of equality and hierarchy within Indonesia’s civil service reform under Law No. 20 of 2023, which formally establishes parity between Civil Servants (PNS) and Government Employees with Employment ...
Herry Febriadi, Krisnadi Nasution, Syofyan Hadi   +2 more
doaj   +1 more source