Results 51 to 60 of about 2,644,827 (313)
Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti +9 morewiley +1 more sourceReseArch with Patient and Public invOlvement: a RealisT evaluation - the RAPPORT study [PDF]
, 2015 Background
Patient and public involvement (PPI) is a prerequisite for many funding bodies and NHS research ethics approval. PPI in research is defined as research carried out with or by the public rather than to, about or for them.Abbott, Abma, All-Party Parliamentary Group, Andejeski, Armes, Astbury, Badger, Baggott, Baggott, Barber, Barber, Barber, Barbour, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Barnes, Batsch, Baxter, Ben-Ari, Beresford, Bhaskar, Boivin, Boote, Boote, Boote, Boote, Brannen, Brett, Brett, Brett, British Paediatric Surveillance Unit, Broerse, Burrus, Cairncross, Caldon, Callard, Caron-Flinterman, Carter, Chalmers, Clark, Clavier, Collaboration for Leadership in Applied Health Research and Care, Collier, Connelly, Connelly, Consumers Health Forum of Australia, Cotterell, Cotterell, Cystic Fibrosis Trust, Davis, Davis, Delanty, Delbanco, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Department of Health, Dewar, Edwards, Elberse, Entwistle, Entwistle, Evans, Expert Patients Programme, Exworthy, Fairbrother, Faulkner, Fiss, Forbat, Forbes, Fulop, Gibson, Goodman, Goodman, Gradinger, Great Britain, Greene, Guarino, Habermas, Habermas, Habermas, Hartley, Hawe, Hayes, Held, Hewitt, Hewlett, Higher Education Funding Council for England, HM Government, HM Government, Hofmann, Howe, Howe, Hunn, Hunt, Iliffe, INVOLVE, INVOLVE, Ives, Jagosh, Jagosh, Jordan, Kontos, Koops, Kreindler, Kreis, Krieger, Langston, Lasker, Lindenmeyer, Lupton, Macaulay, Marchal, Marinetto, Martin, Martin, Mathie, Matthews, May, May, May, May, McCormick, McDonnell, McGrath, McKevitt, McKevitt, McNichol, Medical Research Council, Merton, Meyer, Middleton, Miller, Milton, Minogue, Morrow, Nathan, National Cancer Research Institute, National Institute of Health Research, National Institutes of Health, National Voices, Ocloo, Oliver, Oliver, Oliver, Oliver, O’Cathain, O’Donnell, Palmer, Parkes, Paterson, Patient and Public Involvement Solutions, Pattengill-Semmens, Pawson, Pawson, Pawson, Peckham, Philpot, PiiAF Study Group, Pitt, Prior, Purttell, Renedo, Research Design Service London, Rhodes, Roderick, Royal College of Psychiatry, Royle, Rycroft-Malone, Rycroft-Malone, Savage, Schierhout, Schneider, Schwappach, Scott, Shippee, Shirk, Smith, Snape, Staley, Staley, Staley, Staley, Staniszewska, Staniszewska, Staniszewska, Staniszewska, Staniszewska, Stevens, Strauss, Sutton, Telford, Telford, Terry, Thompson, Thompson, Thompson, Titmuss, Tolson, Tritter, Truman, Vale, van Bekkum, Walker, Wand, Ward, Williams, Williams, Williamson, Wilson, Wilson, Wilson, Wilson, World Health Organization, Wright, Yin +225 morecore +4 more sourcesAggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera +11 morewiley +1 more source“We’re all in this together”: patient and public involvement and engagement in developing a new psychosocial intervention for adults with an intellectual disability who display aggressive challenging behaviour
Research Involvement and EngagementBackground Although there is consensus regarding the added value of adults with an intellectual disability and family carers as Patient and Public Involvement and Engagement (PPIE) members in research studies, there is limited reporting on the practice ...Connor Clarke, Athanasia Kouroupa, Rachel Royston, Angela Hassiotis, Yufei Jin, Vivien Cooper, Robert Daniels, Lisa Grimley, Sue Hay, Louise Marston, Olawole Odeyemi, Ian Penfold, Claire Pullar, Penny Rapaport, Kate Sanger, Adam Southworth, Laurence Taggart, Afia Ali +17 moredoaj +1 more sourceEvaluation of the Establishment of a Public and Patient Involvement and Engagement Group to Support Clinical Trials in Pakistan: Protocol for a Mixed-Methods Study [version 2; peer review: 2 approved]
Wellcome Open ResearchBackground Patient and public involvement and engagement (PPIE) in research is a collaboration between researchers, patients, and the public, enhancing research acceptability, relevance, and impact.Monaza Khan, Shehla Farooq, Srinivas Murthy, Nikhat Ahmed, Saima Saleem, Adnan Masood, Shahnaz Zaman, Zahyd Shuja, Arishay Hussaini, Timo Tolppa, Arjen M Dondorp, Madiha Hashmi +11 moredoaj +1 more sourceThe neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal +8 morewiley +1 more sourceIntegration of patient and public involvement in a doctoral research study using the research cycle
Research Involvement and EngagementBackground Patient and public involvement (PPI) in research is widely acknowledged as essential to achieving successful and impactful research. Despite this acknowledgement, there are limited reports on how to approach and apply meaningful PPI throughout Helen Pearson, Carol Bell, Karl Cox, Catherine Kayum, Leona Knox, Faith Gibson, Michelle Myall, Anne-Sophie Darlington, Emma Potter, Nicholas Bird +9 moredoaj +1 more sourceDual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix +13 morewiley +1 more sourceBig Data Applications: Public Involvement Tools for Public Involvement
, 2022 Using big data to better understand origin-destination and regional travel patterns is critical to project development. Tools such as passive geographically based data lead to improved definitions for traffic analysis zones (TAZs), which, in turn, help inform public involvement plans for a more targeted approach and improved equity.Livingston, Amy L, Ghandour, Houssamopenaire +1 more source
