Results 71 to 80 of about 433,816 (309)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Green open space in large scale housing estates: a place for challenge

open access: yesJournal of Architecture and Urbanism, 2013
The renewal of urban areas by developing green open spaces increases the overall quality of life and helps to reduce social exclusion. Urban green open space can help to constitute a framework where urban society and culture can develop, and to increase ...
Sandra Treija   +2 more
doaj   +1 more source

The disappearance of open public space in the contemporary era: Interior space as space of public interaction

open access: yes, 2023
The COVID-19 pandemic represents a trigger that has led to social transformations whose consequences are yet to unfold. Noticeable changes can be observed in behavior patterns, as well as in communication, and space usage, particularly in public areas.
Petrović, Relja   +2 more
openaire   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Shikii in defining Japanese “public” space: Case study of Shinonome Canal Court in Tokyo

open access: yesJournal of Urban Management
As a concept imported from the West, ‘public’ did not show up in Japanese society until Meiji. This results in a lack of typical public space typologies in Japan's city center, such as square and plaza.
Yang Yang
doaj   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

open access: yesFEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour   +2 more
wiley   +1 more source

Institutions on Public Open Space Governance

open access: yesAsian Journal of Environment-Behaviour Studies, 2018
Meagre discussion on the institutional property-rights structure essence has rudimentarily determined the POS governance and its quality. Thus, two objectives are highlighted; (i) to examine Sabah's current practice (rights distribution) in urban-rural POS governance and (ii) to explore the POS social dilemmas that tied in with such institution ...
Ling, Gabriel Hoh Teck   +2 more
openaire   +3 more sources

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