Results 61 to 70 of about 587,534 (300)

Policy entrepreneurship in collaborative governance: transformative innovation in Catalonia’s sustainability transition

Policy Design and Practice
There is increasing recognition that public sectors in Western countries alone cannot tackle complex societal challenges. However, detailed research on the role of public agents in implementing collaborative approaches remains limited.
Míriam Acebillo-Baqué, Diana Velasco, Alejandra Boni   +2 more
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

COVID-19 AND PUBLIC SPACES; IMPROVING QUALITY AND FLEXIBILITY FOR INTERACTIVE PLACES THROUGH DESIGN [PDF]

, 2022
Fatima Tuz Zahra, Saima Gulzar
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Public design of digital commons in urban places: A case study

International Journal of Human-Computer Studies, 2015
This paper can be framed within the growing interest in the public dimension of technology design: it proposes a framework for the public design of urban technologies by elaborating on the concepts of digital commons, matters of concerns and engagement. The framework is discussed through the case study of a mobility application developed within a wider
Teli, Maurizio, Bordin, Silvia, Menendez Blanco, Maria, Orabona, Giusi, De Angeli, Antonella   +4 more
openaire   +2 more sources

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

The built environment and place attachment: Insights from Japanese cities

Preventive Medicine Reports
Objective: Place attachment plays an important role in individuals' health and well-being. Understanding the associations between urban design attributes and place attachment can inform strategies to promote place attachment.
Jiuling Li, Mohammad Javad Koohsari, Andrew T. Kaczynski, Ryo Tanimoto, Reo Watanabe, Tomoki Nakaya, Yufeng Luo, Jing Zhao, Akitomo Yasunaga, Koichiro Oka, Tomoya Hanibuchi   +10 more
doaj   +1 more source

Years of life lost and mortality due to heat and cold in the three largest English cities

Environment International, 2020
There is a well-established relationship between temperature and mortality, with older individuals being most at risk in high-income settings. This raises the question of the degree to which lives are being shortened by exposure to heat or cold. Years of
Katherine Arbuthnott, Shakoor Hajat, Clare Heaviside, Sotiris Vardoulakis   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Introducing Design Thinking in Social Innovation and in the Public Sector: a design based learning framework

European Public & Social Innovation Review, 2017
Design Thinking (DT) is becoming a mantra in the different areas of innovation: including SI and Public sector (Manzini&Rizzo, 2011; Deserti&Rizzo, 2015).
Francesca Rizzo,, Alessandro Deserti, , Onur Cobanli   +2 more
doaj   +1 more source