Results 81 to 90 of about 587,534 (300)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Predicting the Impact of Urban Development on Locals’ Place Attachment in Peripheral Settlements [PDF]
Urbanism. Arhitectura. ConstructiiAs urban development reshapes cityscapes, residents in peripheral settlements face challenges in maintaining Place Attachment. This study examines the potential disruption of Place Dependence, Place Identity, and Place Affection—core components of Place ...
Farid Nazaruddin +2 more
doaj
Application of Graphics and Color Language in the Public Space of Modern Cites
MATEC Web of Conferences, 2018 It aims to explore the experience design application of graphics and color language in the modern urban public space.We concretely analyzed the response of the graph language and the public space, the resonance of color language and human's emotion,and ...
Shi Mengmeng, Li Yousheng
doaj +1 more source
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Research and Design of Disinfection Equipment for Public Places
International Journal of Education and HumanitiesThe starting point of my design is to redesign the existing product based on the post-epidemic era to make different functional definitions and styling changes.The scientific and technical issues, functional layout distribution, target population and usage scenarios were all well thought out before making the choice.Secondly, this paper focuses on the ...
openaire +1 more source
RUASLandscape architecture significantly contributes to sustainable development by incorporating universal design principles in the design of public open spaces.
Nahdatunnisa +3 more
doaj +1 more source