Results 81 to 90 of about 3,391,421 (303)

Competition and cost overruns. Optimal misspecification of procurement contracts [PDF]

open access: yes
Most cases of cost overruns in public procurement are related to important changes in the initial project design. This paper deals with the problem of design specification in public procurement and provides a rationale for design misspecification.
Juan J. Ganuza
core  

Understanding Situated Social Interactions: A Case Study of Public Places in the City [PDF]

open access: yes, 2008
Udgivelsesdato: 22 AprilUbiquitous and mobile computer technologies are increasingly being appropriated to facilitate people’s social life outside the work domain. Designing such social and collaborative technologies requires an understanding of peoples’
Kjeldskov, Jesper, Paay, Jeni
core   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

PUSAT OLAHRAGA TINJU DI MAKASSAR PENERAPAN ARSITEKTUR FUTURISTIK

open access: yesNature: National Academic Journal of Architecture, 2015
Sports boxing center in Makassar will become a place that has full facilities for boxing fans to watch live matches as well as a place for athletes to gain a science of boxing. Activity center boxing as Landmark new in Makassar by applying the concept of
Syamsul Bahri, Taufik Arfan
doaj   +1 more source

Thou shalt not steal: Effects of normative cues on attitudes towards theft. [PDF]

open access: yes, 2013
In this study, we examine how normative cues influence attitudes towards theft. In a 3 × 2 × 2 within-subjects design (N = 120), we found that people had more negative attitudes towards theft when: 1) a higher value item was stolen than when a lower ...
Abrahamse, W.   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

open access: yesMolecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son   +13 more
wiley   +1 more source

Aquarium in Question. Pushing the limits of the aquatic realm within the urban environment

open access: yesПроект Байкал, 2016
In April 2016, arch out loud announced the winners of the international architectural competition, the task of which was to design NYC AQUARIUM & PUBLIC WATERFRONT. The first place was occupied by NYC AQUATRIUM designed by Italian architects.
Anna Grigorieva
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

Pattern Research Project: An Investigation of The Pattern And Printing Process - Golden Age [PDF]

open access: yes, 2018
2018 Pattern Research Project Michael Rogers – Golden Age The Pattern Research Project involves research and analysis of contemporary patterns found in the textiles and wallcoverings of the built interior environment.
Rogers, Michael
core   +1 more source

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

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