Results 91 to 100 of about 503,476 (353)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Analysis of Multi-Modal Public Transit Competing Relationships and Evolutionary Mechanisms in Cities in Cold Regions

Applied Sciences
In order to reveal the characteristics of the competition and cooperation of multi-modal public transportation in the cities of cold areas and to study the competitive relationship of multi-modal public transportation in cold areas, the urban public ...
Yulong Pei, Wanjiao Wang
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Public transit infrastructure and heat perceptions in hot and dry climates [PDF]

, 2021
Yuliya Dzyuban, David M. Hondula, Paul Coseo, Charles L. Redman   +3 more
openalex   +1 more source

A Longitudinal Analysis of Cars, Transit, and Employment Outcomes [PDF]

, 2015
Access to cars and transit can influence individuals’ ability to reach opportunities such as jobs, health care, and other important activities. While access to cars and public transit varies considerably across time, space, and across populations, most ...
Klein, Nicholas J., Smart, Michael J.
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Research on Urban Rail Transit 5G Public-private Network Wireless Coverage Scheme

Chengshi guidao jiaotong yanjiu
Objective The urban rail transit 5G public-private network (PPN) is a vertical application of 5G public network in urban rail transit industry, which differs significantly from the wireless coverage scheme of the 5G public network when only catering to ...
Weijun LIU
doaj   +1 more source

Neighborhood Crime and Travel Behavior: An Investigation of the Influence of Neighborhood Crime Rates on Mode Choice – Phase II, MTI Report 11-04 [PDF]

, 2012
There are considerable environmental and public health benefits if people choose to walk, bicycle, or ride transit, instead of drive. However, little work has been done on the effects of neighborhood crimes on mode choice.
Ferrell, Christopher, Mathur, Shishir, Meek, Justin, Piven, Matthew   +3 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Transit Manipulation by the Koch Brothers: Analyzing the Relationship between the Division of Power in the United States Government, Societal Benefits, Voter and Rider Composition, Referendum Language and Cost of Improvement Under the Lens of the 2018 Nashville Transit Improvement Program Referendum [PDF]

, 2020
Transit Manipulation by the Koch Brothers: Analyzing the Relationship between the Division of Power in the United States Government, Societal Benefits, Voter and Rider Composition, Referendum Language and Cost of Improvement Under the Lens of the 2018 ...
Lee, Samantha
core   +1 more source