Results 61 to 70 of about 523,457 (304)
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
FLEXIBLE PUBLIC TRANSPORT SERVICE – SOLUTION FOR LOW PUBLIC TRANSPORT DEMAND AREAS
Perner’s Contacts, 2006 This paper deals with problematic of implementation of flexible public transport service in low demand areas. In spite of many advantage, it is not such of type of public transport service implemented, even if the real reasons in operational and ...
Marián Gogola
doaj
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Tehnički Glasnik, 2020 Public transport plays an increasingly important role in satisfying the transport needs. Travellers’ requirements regarding the quality of services are increasing.
Piotr Gołębiowski +2 more
doaj
Communications, 2019 A machine learning approach for the recent detection of crossing faults is presented in the paper. The basis for the research are the data of the axle box inertial measurements on operational trains with the system ESAH-F.
Mykola Sysyn +4 more
doaj +1 more source
A Study Of Public-Private Partnerships Through The Public Value Lens: Case Study Of Transport Infrastructure Provision In Vietnam [PDF]
, 2023 Hoa Dao
openalex +1 more source
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
European Journal of Transport and Infrastructure Research, 2005 The paper deals with the question of how suspension of the subsidies for public transport operations in the Netherlands would affect the public transport system.
Kees van Goeverden, Paul Peeters
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source