Results 91 to 100 of about 6,232,974 (300)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Investigating the Usage Pattern of Tabriz University of Medical Sciences Users of E-journals during 2010-2012 based on Counter Reporting [PDF]

Taṣvīr-i salāmat, 2015
Background and objectives: The increase in the use of electronic resources in academic and scientific research centers and rising cost of preparing and getting access to these resources is the main reason for the importance of evaluating the amount of ...
Sara Jalalzaeh, Fahimeh Abbasi
doaj  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Study Protocol - Assessing the feasibility of ‘Screening by Accredited Social Health Activist (ASHAs) and diagnosis by Community Health officers of Asthma and COPD at the primary health care System- A Novel Strategy- SHVASAN’

Frontiers in Health Services
Underestimating the burden of Chronic respiratory diseases (COPD-Asthma) is a past error that needs to be remedied, and cases with these diseases are to be screened and diagnosed!
Ashwini Kishor Devane, Jayashree Sachin Gothankar, Jayashree Sachin Gothankar, Prakash PrabhakaRrao Doke   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Publicação responsável de pesquisa: padrões internacionais para autores [PDF]

Cadernos de Pesquisa, 2014
Elizabeth Wager, Sabine Kleinert
doaj   +1 more source

Plant- and soil-derived polyphenols shape soil microbiomes and crop outcomes: a systematic review and meta-analysis

Frontiers in Soil Science
BackgroundPolyphenols from root exudates and polyphenol-rich organic inputs may shape soil microbiomes, enzyme activities, and crop nutrient outcomes, with relevance to regenerative agriculture.ObjectivesTo quantify the effects of plant- and soil-derived
Okechukwu Paul-Chima Ugwu, Fabian C. Ogenyi, Esther Ugo Alum, Mariam Basajja, Jovita Nnenna Ugwu, Chinyere N. Ugwu, Regina Idu Ejemot-Nwadiaro, Regina Idu Ejemot-Nwadiaro, Michael Ben Okon, Uti Daniel Ejim, Mundu M. Mustafa, Ashiru Muhammad, Ashiru Muhammad, Fadia Ahmed Abdelkader Reshia   +13 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source