Results 71 to 80 of about 10,706,018 (302)

Nanoparticle-mediated mRNA delivery for cancer, autoimmunity, and genetic diseases: a rapid review

Frontiers in Drug Delivery
IntroductionMessenger RNA (mRNA) therapeutics have advanced from experimental platforms to clinical application, driven largely by the success of lipid nanoparticle (LNP)-based COVID-19 vaccines.
Okechukwu Paul-Chima Ugwu, Fabian C. Ogenyi, Mariam Basajja, Chinyere N. Ugwu, Mundu M. Mustafa, Michael Ben Okon   +5 more
doaj   +1 more source

Managing for change: August 13, 1990 v. 1, no. 3 [PDF]

, 1990
Bi-weekly newsletter of University Hospital's Change Project, provided to managers at the ...
Boston University Medical Center, Office of Publication Services
core  

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Synergistic phytochemicals in multi-target drug discovery for complex diseases: A narrative review

Phytomedicine Plus
Background/problem statement: Single-target pharmaceutical treatments generally fail to address the complex pathophysiology of chronic illnesses such as cancer, cardiovascular disorders, diabetes, and neurodegeneration.
Okechukwu Paul-Chima Ugwu, Melvin Nnaemeka Ugwu, Fabian C. Ogenyi, Esther Ugo Alum, Val Hyginus Udoka Eze, Mariam Basajja, Jovita Nnenna Ugwu, Michael Ben Okon, Chinyere N. Ugwu, Chinyere Nkemjika Anyanwu, Joseph Obiezu Chukwujekwu Ezeonwumelu, Dominic Terkimbi Swase, Bulhan Samanya, Simeon Ikechukwu Egba, Daniel Ejim Uti, Hope Onohuean   +15 more
doaj   +1 more source

Special connections: June 17, 1992 [PDF]

, 1992
Time-sensitive news update to monthly University Hospital ...
Office of Publication Services, Boston University Medical Center
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Special connections: May 14, 1992 [PDF]

, 1992
Time-sensitive news update to monthly University Hospital ...
Office of Publication Services, Boston University Medical Center
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Special connections: October 23, 1992 [PDF]

, 1992
Time-sensitive news update to monthly University Hospital ...
Office of Publication Services, Boston University Medical Center
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source